Antioxidant Activity of Ferulic Acidβ-Glucuronide in the LDL Oxidation System

Phenolic acids from beer are absorbed and extensively metabolized in humans

“…For quercetin, one of the most abundant flavonoids in the human diet, it has been described that the conjugated forms, quercetin glucuronides and quercetin 3-O-sulfate, still retain antioxidant activity, although to a less extent with respect to quercetin [14]. The antioxidant activity of ferulic acid glucuronide, which has not only the hydrophobic ferulic acid moiety but also a hydrophilic sugar moiety, is stronger than that exhibited by ferulic acid [16].…”

Protective effects of curcumin and photo‐irradiated curcumin on circulatory lipids and lipid peroxidation products in alcohol and polyunsaturated fatty acid‐induced toxicity

“…By virtue of effectively scavenging deleterious radicals and suppressing oxidative reactions, FA is shown as an important antioxidant (Graf, 1992). Reports have shown that FA is absorbed as Ferulic acid β-glucuronide, and the antioxidant property of ferulic acid is not only due to the hydrophobic FA but also due to the hydrophilic sugar moiety (Ohta et al, 1997). Thus FA is proved to be an effective antioxidant.…”

Wheat bran feruloyl oligosaccharides enhance the antioxidant activity of rat plasma

“…Conjugated FA including FA-glucuronide, FA-sulphate and FA-sulphoglucuronide are the major metabolites in the plasma and urine of rats (Zhao & Moghadasian, 2008). Ohta, Nakano, Egashira, and Sanada (1997) reported that FA metabolites and especially glucuronidates reduced in a significant way the formation of conjugated dienes in the low density lipoprotein oxidation system. The plasma obtained from rats after quercetin and proanthocyanidin administration, which contains glucuronide and/or sulphate conjugates, was more resistant against copper sulphate-induced lipid peroxidation than the control plasma (Da Silva, Piskula, Yamamoto, & Moon, 1998;Koga et al, 1999).…”