Antioxidant Activity of Elaeis guineensis Leaf Extract: An Alternative Nutraceutical Approach in Impeding Aging

Vijayarathna, Soundararajan; Sasidharan, Sreenivasan

doi:10.1016/j.apcbee.2012.06.028

Cited by 22 publications

(18 citation statements)

References 29 publications

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“…Antioxidant phytochemicals have the potential to fight against aging and its related disorders. For example, coffee, which contains high levels of antioxidant phytochemicals, reduced both motor and cognitive deficits in aged rats [107], and methanol extract of Elaeis guineensis leaves with high antioxidant activities also showed potential ability as an anti-aging agent [108]. In addition, antioxidant phytochemicals showed anti-ageing activities by different mechanisms.…”

Section: Prevention and Treatment Of Antioxidant Phytochemicals Fomentioning

confidence: 99%

Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases

et al. 2015

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Overproduction of oxidants (reactive oxygen species and reactive nitrogen species) in the human body is responsible for the pathogenesis of some diseases. The scavenging of these oxidants is thought to be an effective measure to depress the level of oxidative stress of organisms. It has been reported that intake of vegetables and fruits is inversely associated with the risk of many chronic diseases, and antioxidant phytochemicals in vegetables and fruits are considered to be responsible for these health benefits. Antioxidant phytochemicals can be found in many foods and medicinal plants, and play an important role in the prevention and treatment of chronic diseases caused by oxidative stress. They often possess strong antioxidant and free radical scavenging abilities, as well as anti-inflammatory action, which are also the basis of other bioactivities and health benefits, such as anticancer, anti-aging, and protective action for cardiovascular diseases, diabetes mellitus, obesity and neurodegenerative diseases. This review summarizes recent progress on the health benefits of antioxidant phytochemicals, and discusses their potential mechanisms in the prevention and treatment of chronic diseases.

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Section: Prevention and Treatment Of Antioxidant Phytochemicals Fomentioning

confidence: 99%

Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases

et al. 2015

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“…Although the leaf of the oil palm is a waste product, the alcohol extract of the leaf contains large amounts of phenolic compounds [12,13] that reportedly promote vascular relaxation and antioxidant activity in vitro [14]. In a recent study of streptozotocin (STZ)-induced hyperglycemic rats, E. guineensis leaf extract reduced glycemia and lipid oxidation in a dose-dependent manner, possibly by inhibiting dipeptidyl peptidase-4 (DPP-4) secretion [15].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of Elaeis guineensis and Ficus deltoidea leaf extracts in adults with pre-diabetes

Schwartz¹,

Feldman²,

Krieger³

2013

Nutr J

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BackgroundIndividuals with pre-diabetes (fasting glucose 100–125 mg/dl) are at increased risk of developing diabetes; 50% of U.S. adults aged ≥65 y had pre-diabetes in 2005–08. Extracts of the leaves of E. guineensis (a tropical plant producing edible oil), and F. deltoidea (a traditional tea) contain phenolic compounds that have hypoglycemic effects in vitro and in vivo. Therefore, a study of the efficacy and safety of these leaf extracts was undertaken.MethodsOtherwise healthy adults with pre-diabetes (15m/15f; aged 21 to 65 y; BMI ≥25 and < 40 kg/m2) were assigned to one of 3 groups for 8 weeks: E. guineensis leaf extract 500 mg or 1000 mg or F. deltoidea leaf extract 1000 mg. Assessments at baseline and throughout the study included: fasting plasma glucose, insulin, OGTT, and HOMA-IR; body weight and waist circumference; vital signs, comprehensive metabolic and lipid panels. Statistical analyses included paired Student’s t-test and ANCOVA or non-parametric tests when indicated.ResultsE. guineensis intervention for 8 weeks decreased fasting plasma glucose and insulin levels, glucose and insulin areas under the curve, and insulin resistance, and increased insulin sensitivity. The 500 mg dose of E. guineensis had a more consistent effect on reducing glycemia than the 1000 mg dose and the insulin findings at the two dose levels were somewhat inconsistent. Differences in the distribution of baseline insulin levels in the low and high dose groups may explain some of these observed differences in responses. F. deltoidea leaf extract had no effect on glycemia variables but both total and LDL cholesterol concentrations were significantly decreased in this group. There were no significant differences in change of weight; however waist circumference was significantly lower in the E. guineensis groups after intervention. At baseline and after 8 weeks of intervention, vital signs and safety lab tests were within normal limits and not significantly different between groups or due to intervention.ConclusionsThese results suggest that the leaf extracts of E. guineensis and F. deltoidea may have positive effects on glucose and lipid levels and are safe for use in humans. Further study is required to determine the maximum effective dosages and the mechanisms of action.

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“…L'extrait éthanolique des feuilles de Elaeis guineensis a des propriétés préventives, thérapeutiques et apoptotiques sur les processus inflammatoires (Prasain et al, 2010 ;Namvar et al, 2012 ;Yin et al, 2013) et son ingestion par des rongeurs hypertendus, déficients et normaux réduit les hépatocytes anormaux, corrige les dommages hépatocellulaires (Jaffri et al, 2011), et diminue également les dommages glomérulaires causés par l'hypertension chronique (Husain et al, 2001). Ce même extrait accélère l'épithélialisation des blessures ainsi que la granulation des tissus endommagés chez les animaux diabétiques (Yin et al, 2013) et possède des propriétés de relaxation vasculaire et anti-oxydante in vitro (Vijayarathna et sasidharan (2012). Elaeis guineensis présente des propriétés hépato-protecteurs contre les dommages histopathologiques induits par le paracétamol sur le foie des souris (Sasidharan et al, 2009(Sasidharan et al, , 2012.…”

Section: Elaeis Guineensisunclassified

Activités biologiques et utilisations de <i>Elaeis guineensis</i> (Jacq) et de <i>Khaya senegalensis</i> (Desr) en médecine traditionnelle humaine et vétérinaire

Soha¹,

Dougnon²,

Ohouko³

et al. 2019

Int. J. Bio. Chem. Sci

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Khaya senegalensis et Elaeis guineensis sont deux plantes médicinales utilisées pour traiter diverses maladies bactériennes, virales, inflammatoires et parasitaires. Le présent travail fait un état des lieux des activités biologiques et l'usage de ces deux plantes en santé animale et en médecine traditionnelle. Ainsi, après une brève description botanique et la présentation des noms locaux de Khaya senegalensis et de Elaeis guineensis, les compositions chimiques des différents organes des deux plantes ont été présentées. Il s'en est suivi le récapitulatif des différents usages médicinaux et traditionnels de ces plantes en santé animale et humaine. De plus, quelques activités biologiques et les indications thérapeutiques possibles ont été exposées et enfin, les niveaux de toxicités présentés pour un meilleur usage des différentes préparations médicamenteuses. Ces deux plantes, non toxiques à des doses modérées sont prisées par les populations rurales pour se soigner et assurer l'état sanitaire de leurs animaux en fonction de la disponibilité et l'efficacité de ces dernières. Les différentes potentialités des plantes ouvrent la perspective d'évaluation de l'efficacité de leurs extraits dans le contrôle des maladies parasitaires du bétail et spécialement dirigée contre les trypanosomes.

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Antioxidant Activity of Elaeis guineensis Leaf Extract: An Alternative Nutraceutical Approach in Impeding Aging

Cited by 22 publications

References 29 publications

Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases

Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases

Efficacy and safety of Elaeis guineensis and Ficus deltoidea leaf extracts in adults with pre-diabetes

Activités biologiques et utilisations de <i>Elaeis guineensis</i> (Jacq) et de <i>Khaya senegalensis</i> (Desr) en médecine traditionnelle humaine et vétérinaire

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