Antioxidant activity of different species and varieties of turmeric (Curcuma spp): Isolation of active compounds

Akter, Jesmin; Hossain, Md. Amzad; Takara, Kensaku; Islam, Md. Zahorul; Hou, De‐Xing

doi:10.1016/j.cbpc.2018.09.002

Cited by 90 publications

(74 citation statements)

References 35 publications

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“…The European Union has recommended the use of numerous medicinal plants for the treatment of gastrointestinal disorders, and among them are ginger root (Z. officinale) and turmeric root (C. longa) [38]. [39,40]. Curcumin from C. zedoaria, as from C. longa, shows good anti-inflammatory effects [36].…”

Section: Recent Publications On the Ginger Familymentioning

confidence: 99%

Polyploidy in the Ginger Family from Thailand

Anamthawat‐Jónsson¹,

Umpunjun²

2020

Chromosomal Abnormalities

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Polyploidy is common in the ginger family Zingiberaceae. The aims of the present paper are (1) to provide a general introduction on species diversity with emphasis on conservation; (2) to highlight the human-use significance of this family, focusing on the two major genera, Zingiber (ginger) and Curcuma (turmeric); (3) to present chromosome number data from 45 natural and cultivated Curcuma taxa from Thailand, of which polyploids are predominant; and (4) to describe our own work on cytotaxonomy of selected Thai Curcuma species. We obtained somatic chromosome numbers from root tips and analysed meiotic chromosome behaviour from flowers. We also used the molecular cytogenetic method of ribosomal gene mapping on chromosomes to infer mechanism of polyploidization and reveal genomic relationships among closely related species. The main results of our cytogenetic studies include the following. The most sought-after medicinal Curcuma cultivars growing on a large-scale basis are secondary triploids, so as taxa in natural habitats that are harvested for local utilisation. These triploids are sexually deficient, due to meiotic pairing abnormalities, but they are propagated asexually via rhizomes. The ribosomal mapping results indicate natural triploidization process via hybridisation, either within populations or across the species boundaries.

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Section: Recent Publications On the Ginger Familymentioning

confidence: 99%

Polyploidy in the Ginger Family from Thailand

Anamthawat‐Jónsson¹,

Umpunjun²

2020

Chromosomal Abnormalities

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“…For example, curcumin, DMC, and BDMC displayed free radical scavenging activity with IC 50 values 31.8, 92.5, and 104.4 µM, respectively [23]. In another study by Akter et al, (2019), the IC 50 values were 18, 47, and 198 µM for curcumin, DMC, and BDMC, respectively [24]. In the present study, curcuminoids effectively exhibited DPPH scavenging activity with IC 50 = 9.14 µM in a cell-free system.…”

Section: Discussionmentioning

confidence: 93%

Cytotoxicity of Standardized Curcuminoids Mixture against Epithelial Ovarian Cancer Cell Line SKOV-3

et al. 2020

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Herbal medicine has been in use for centuries for a wide variety of ailments; however, the efficacy of its therapeutic agents in modern medicine is currently being studied. Curcuminoids are an example of natural agents, widely used due to their potential contribution in the prevention and treatment of cancer. In this study, the three main compounds of curcuminoids-curcumin, desmethoxycurcumin, and bisdesmethoxycurcumin-were determined by reversed-phase high performance liquid chromatography (HPLC) to quantify total content in a mixture. Subsequently, the effect of the three curcuminoids, employed as one sample, was evaluated, to study the proliferation, apoptosis, cell cycle, and migration of the human ovarian cancer cell line SKOV-3. The results reveal that curcuminoids inhibit the proliferation of SKOV-3 cells with concentration-and time-dependent mechanisms. The morphological analysis of the treated SKOV-3 cells showed a typical apoptotic phenotype-cell shrinkage and membrane blebbing in a dose-dependent manner. In addition, flow cytometry demonstrated an increase in apoptosis with an IC 50 of 30 µM curcuminoids. The migration of SKOV-3 cells was also inhibited, reflected by a decrease in wound area. Furthermore, the curcuminoids were found to have no stimulation effect on the expression of cytokines TNF-α and IL-10. These results suggest that a curcuminoid mixture can effectively suppress epithelial cancer cell growth in vitro by inducing cellular changes and apoptosis.

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“…Lower antioxidant activities of C. zedoaria and C. aromatica may depend on the lower levels of phenolic and flavonoid contents in both of them compared with C. longa and C. xanthorrhiza [3]. Using DART-TOFMS, curcumin (1) was not detected from the rhizomes of C. zedoaria and C. aromatica cultivated in the medicinal plant garden.…”

Section: Superoxide Anion Radical (O 2 •ˉ) Scavenging Activity Of Rhimentioning

confidence: 95%

“…It has also been used for medicinal purposes, e.g. as a cholagogue and as an anti-inflammatory, anti-angiogenic, antibacterial, anti-fungal, analgesic, immunomodulatory, vasodilatory, anti-diabetes, and anti-Alzheimer's disease agent [2,3].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Compounds of Curcuma Rhizome Using Mass Spectrometry and Investigation of the Antioxidant Activity of Rhizome Extracts

Kasai¹,

Yamane²,

Ikegami-Kawai³

et al. 2019

Med Aromat Plants

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The medicinal plant garden of Hoshi University located in southern Tokyo is home to many medicinal plants, and analysis of odor and measurement of antioxidant activity of cultivated plant have been carried out. In this study compounds originated from Curcuma rhizomes, i.e., Curcuma longa, Curcuma aromatica, Curcuma zedoaria, Curcuma xanthorrhiza, were investigated and antioxidant activities of rhizome extracts were measured. Volatile compounds originating from the Curcuma rhizomes were analyzed using thermal desorption (TD)-GC-MS with solid-phase micro extraction fiber as an adsorption device. p-Cymene, 1,8-cineol, β-elemene, and β-caryophyllene were the predominant constituents in most cases. Curcuminoids, which were not identified by TD-GC-MS, were detected using direct analysis in real time time-of-flight MS. Curcumin and demethoxycurcumin were detected from both C. longa and C. xanthorrhiza. The antioxidant activity of each Curcuma species rhizome was confirmed using the electron spin-resonance spin-trapping method with potent scavenging activity against superoxide anion radicals. Extracts from Curcuma rhizomes cultivated in the medicinal plant garden exhibited antioxidant activities, and the order of the activity of methanol extracts was: C. longa>C. xanthorrhiza>C. aromatica>C. zedoaria. Phenolic compounds, particularly curcumin, are known to possess potent antioxidant activity and are extracted with methanol, thus it reflects the intensity of the antioxidant activity.

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Antioxidant activity of different species and varieties of turmeric (Curcuma spp): Isolation of active compounds

Cited by 90 publications

References 35 publications

Polyploidy in the Ginger Family from Thailand

Polyploidy in the Ginger Family from Thailand

Cytotoxicity of Standardized Curcuminoids Mixture against Epithelial Ovarian Cancer Cell Line SKOV-3

Analysis of Compounds of Curcuma Rhizome Using Mass Spectrometry and Investigation of the Antioxidant Activity of Rhizome Extracts

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