Antioxidant activity of different parts of <i>Pistacia khinjuk</i> Stocks fruit and its correlation to phenolic composition

Hatamnia, Ali Asghar; Rostamzad, Arman; Malekzadeh, Parviz; Darvishzadeh, Reza; Abbaspour, Nasser; Hosseini, Mohammadyar; Nourollahi, Khoshnood; Mehr, Reza Sheikh Akbari

doi:10.1080/14786419.2015.1060593

Cited by 30 publications

(15 citation statements)

References 15 publications

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“…These products could be a good source of anticholinesterase compounds (Hacıbekiroğlu et al 2015), and have antioxidant and urease inhibitory activity (Asghar Hatamnia et al 2015;Uddin et al 2015). Different studies evaluated species and subspecies of pistachios to find their ecological distribution and their karyotype (Ayaz & Namli 2009).…”

Section: Introductionmentioning

confidence: 99%

Fatty acids determination in Bronte pistachios by gas chromatographic method

Pantano

Alongi

et al. 2016

Natural Product Research

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A gas chromatographic with flame ionization detector (GC-MS FID) method for the identification and quantification of fatty acids based on the extraction of lipids and derivatisation of free acids to form methyl esters was developed and validated. The proposed method was evaluated to a number of standard FAs, and Bronte pistachios samples were used for that purpose and to demonstrate the applicability of the proposed method. In this regard, repeatability, mean and standard deviation of the analytical procedure were calculated. The results obtained have demonstrated oleic acid as the main component of Bronte pistachios (72.2%) followed by linoleic acid (13.4%) and showed some differences in composition with respect to Tunisian, Turkish and Iranian pistachios.

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Section: Introductionmentioning

confidence: 99%

Fatty acids determination in Bronte pistachios by gas chromatographic method

Pantano

Alongi

et al. 2016

Natural Product Research

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“…The antimicrobial properties of the native species are known [ 10 , 11 , 12 ]. The use of different species of Pistachio as antibacterial, antifungal, antiviral, anti-atherogenic, hypoglycemia, antitumor and facilitating hepatic function is known [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial effect of Pistacia atlantica leaf extract

et al. 2016

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The antimicrobial effect of the mastic tree (Pistacia atlantica) under in vitro conditions has been reported. Therefore, it is of interest to evaluate the effect of the plant leaf extract (aqueous) on bacterial load in mouth and saliva. The leaf of the Pistacia atlantica plant was collected and cleaned, dried at 40⁰c and then powdered. The extraction was carried out using the maceration method in vacuum with the rotary evaporator device. Bacterial inhibition (Streptococcus species) by the leaf extract was studied using the disc diffusion and embedding sink diffusion methods. The values of MIC and MBC were determined. The collected data was further analyzed using t-test and repeated measure statistical tests. The disc diffusion technique showed a significant inhibitory effect for Pistacia atlantica leaf extract on S. mutans (ATCC 35668) and S. mitis (ATCC 49456) with inhibition zones of 19 and 25 millimeters, respectively. This is for the highest leaf extract concentration used in this study (p<0.01). The values of MIC and MBC for S.mutans was 60, 90 μg/ml and for S. mitis was 75, 110 μg/ml (p<0.01 significance). The leaf extract has no significant effect on S. salivarius (ATCC 13419). Thus, the antimicrobial properties of the aqueous leaf extract from Pistacia atlantica is demonstrated in this study.

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“…1 Mastic and extracts of gum mastic have been used in traditional medicine for more than 5000 years as a dietary extract for the treatment of digestive disorders, 3 and its properties have been further examined in recent years. In vitro and experimental in vivo studies demonstrated that mastic and its extract have antitumor properties; [4][5][6] antibacterial, antifungal, and antiviral activities; [7][8][9][10][11][12][13][14] antioxidant activity; [15][16][17][18][19][20] analgesic activity; 21 and anti-inflammatory activities. [22][23][24][25] Based on this large number of potentially beneficial effects, it is currently in use in health care products and in the food industry.…”

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confidence: 99%

A First‐in‐Human Phase 1 Randomized Single and Multiple Ascending Dose Study of RPh201 in Healthy Volunteers

Hazan

Adamsky

Lucassen

et al. 2019

Clinical Pharm in Drug Dev

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RPh201 is a drug extracted from gum mastic that has been studied for its anti‐inflammatory and antibacterial properties. Preclinical studies of RPh201 demonstrated neuroprotective and neuroenhancing effects. Toxicology studies in animals did not reveal safety concerns or genotoxic effects. This single‐center, phase 1, randomized, placebo‐controlled, double‐masked study in healthy volunteers assessed the safety and tolerability of RPh201, and determined the highest tolerated dose. There were 2 parts: a single ascending dose (SAD) stage, followed by a multiple ascending dose (MAD) stage. Three dosing arms were included in each stage (5 mg, 10 mg, and 20 mg). Safety data in the lower dosing arms were evaluated before higher doses were initiated. Eighteen participants were randomized in the SAD stage: 12 to RPh201 (4 at each dose) and 4 to placebo. Twenty‐one participants were randomized in the MAD stage, of which 13 received RPh201. All 18 participants in the SAD stage completed treatment. Sixteen of the 21 participants in the MAD stage completed treatment. The most frequently reported adverse events were local injection site pain and erythema. No deaths or adverse events related to changes in vital signs or electrocardiograms were reported. No occurrences of suicidal behavior or ideation were reported.

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Antioxidant activity of different parts of Pistacia khinjuk Stocks fruit and its correlation to phenolic composition

Cited by 30 publications

References 15 publications

Fatty acids determination in Bronte pistachios by gas chromatographic method

Fatty acids determination in Bronte pistachios by gas chromatographic method

Antimicrobial effect of Pistacia atlantica leaf extract

A First‐in‐Human Phase 1 Randomized Single and Multiple Ascending Dose Study of RPh201 in Healthy Volunteers

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