Antioxidant activity of chalcones: The chemiluminescence determination of the reactivity and the quantum chemical calculation of the energies and structures of reagents and intermediates

Vasil’ev, R. F.; Kancheva, V. D.; Fedorova, G. F.; Batovska, Daniela; Trofimov, A. V.

doi:10.1134/s0023158410040087

Cited by 34 publications

(32 citation statements)

References 18 publications

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“…Chalcones (1,3-diaryl-2propen-1-ones) and their derivatives exhibit different pharmacological and biological activities, the major ones being antifungal (Bag et al, 2009;Lahtchev et al, 2008;Mostahar et al, 2007), antimicrobial (Yayli et al, 2006;Trivedi et al, 2008;Opletalova, 2000;Katade et al, 2008), anticonvulsant (Kaushik et al, 2010), antioxidant (Vasilev et al, 2010Vogel et al, 2008, Cheng et al, 2008, antiprotozoal (Lunardi et al, 2003), antitrichomonal (Oyedapo et al, 2004), antimalarial (Motta et al, 2006;Awasthi et al, 2009;Lim et al, 2007;Wu et al, 2002;Liu et al, 2001), anti-inflammatory (Yadav et al, 2010;Zhang et al, 2010;Herencia et al, 1998;Nowakowska 2007), trypsin inhibition (Maliar et al, 2004) and anti-cancer activity (Achanta et al, 2006;Romagnoli et al, 2008;Echeverria et al, 2009;Szliszka et al, 2009;Ilango et al, 2010;Wattenberg et al, 1994;Edwards et al, 1988;Kumar et al, 2011;Seo et al, 2010). Chalcones (1,3-diaryl-2propen-1-ones) and their derivatives exhibit different pharmacological and biological activities, the major ones being antifungal (Bag et al, 2009;Lahtchev et al, 2008;Mostahar et al, 2007), antimicrobial (Yayli et al, 2006;…”

Section: Introductionmentioning

confidence: 99%

Ferrocenyl chalcones with O-alkylated vanillins: synthesis, spectral characterization, microbiological evaluation, and single-crystal X-ray analysis

et al. 2016

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O-alkylated vanillin derivatives 2a-f and acetyl ferrocene react under Claisen-Schmidt conditions, resulting in good-to-high yields of the corresponding ferrocene chalcones 3a-f. None of the resultant compounds 3b-f has been previously described in the literature. All synthesized compounds were characterized by spectral and physical data, whereas two of them, 1-ferrocenyl-3-(4-ethoxy-3methoxyphenyl)-prop-2-en-1-one (3b) and 1-ferrocenyl-3-(4-buthoxy-3-methoxy-phenyl)-prop-2-en-1-one (3e), were crystalline substances, suitable for single-crystal Xray analysis, which confirmed undoubtedly their structures.Chalcones 3a-f were tested for their biological activity and demonstrated relatively good in vitro antimicrobial activity towards different strains of bacteria and fungi. The best antibacterial activity is expressed by compounds 3b and 3c, while compound 3d shows the best antifungal activity.

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Section: Introductionmentioning

confidence: 99%

Ferrocenyl chalcones with O-alkylated vanillins: synthesis, spectral characterization, microbiological evaluation, and single-crystal X-ray analysis

et al. 2016

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“…In the excess of oxygen , such kinds of radical species may undergo pseudo unimolecular transformations to afford the labile peroxide (in particular, dioxetane) intermediates, which may then decompose with the formation of electronically excited ( 3 n π *) carbonyl species able to emit light . In this connection, noteworthy is the evidence for an unexpected reaction pathways of hydrocarbon oxidation processes in the presence of mono‐ and polyphenolic compounds. The mentioned cases refer to the possibility of interaction between the phenoxyl radical intermediates with molecular oxygen followed by the formation of the corresponding peroxyl radicals (of a quinoid‐type structure), and the latter may undergo cyclization to form dioxetane radical species.…”

Section: Resultsmentioning

confidence: 92%

Chemiluminescence of Cigarette Smoke: Salient Features of the Phenomenon

Fedorova

Menshov

Trofimov

et al. 2017

Photochem & Photobiology

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The study disclosed herein provides for the first time a detailed experimental support for the general mechanism of the cigarette-smoke-derived chemiluminescence, as an example par excellence of the excited-state generation in a chemically complex aerosol medium. The mechanism involves chemiexcitation in a unimolecular transformation of the smoke-borne free radical species. However, the concentration of these radicals, [r∙], obeys a bimolecular (second-order) kinetics and depends on a particulate-phase content (total particulate matter, TPM) of the cigarette smoke. The decrease in [r∙] with increasing the TPM amount manifests radical-scavenging propensity of the smoke particulate phase. Astonishingly, no energy transfer takes place from the primary excited light-emitting species to luminophoric molecules abundant in the smoke. The reported results build up fundamentals of a facile chemiluminescence assay for free radical properties of the smoke. The experimental approaches developed for this study are of general scope and may be used for mechanistic elucidation of the excited-state generation in chemical systems and environments of an arbitrary complexity.

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“…Chalcones and its derivatives possess several pharmacological activities such as antibacterial [138,139], anticancer [140][141][142][143][144], antimitotic [141], anticonvulsant [145], antifilarial [146], antifungal [147,148], antiinflammatory [149,150], antimalarial [151][152][153][154], antimicrobial [155], antioxidant [156][157][158], antiprotozoal (antileishmanial and antitrypanosomal) [159], and larvicidal [160]. They have also been reported to show inhibitory activity against many enzymes including cyclooxygenase [161], mammalian alphaamylase [162], and monoamine oxidase [163].…”

Section: Pharmacological Actionsmentioning

confidence: 99%