Antioxidant Activity of a Series of FluorinatedPyrano-nucleoside Analogues of N4-benzoyl Cytosine andN6-benzoyl Adenine

Abstract

Fluorinated nucleoside analogues are known as antitumor, antiviral and chemotherapeutic agents, although the antioxidant activity of this kind of molecules is not yet investigated. In this study we have tested the antioxidant activity of a series of modified pyrano-nucleoside analogues using three in vitro assays. Firstly, the antioxidant capacity of the products was assessed using the DPPH assay and secondly, in order to examine the ability of the products to protect DNA from the activity of reactive oxygen species (ROS), a peroxyl radical (ROO • ) and a hydroxyl radical (OH • ) induced DNA strand scission assay were used. None of the molecules showed the ability to scavenge DPPH radical and prevent OH• induced DNA strand breakage. Although, most of the tested nucleoside analogues, had the ability to prevent ROO • induced DNA damage.

Isolation and characterization of functional components from peel samples of six potatoes varieties growing in Ontario

“…Method described by (Spanou, Manta, Komiotis, Dervishi, & Kouretas, 2007)was used with some modifications. 3 ml of 0.1 mM 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) in methanol was added to 250 ll of extract.…”

Synthesis, Antiviral and Cytostatic Evaluation of Unsaturated Exomethylene and Keto D‐Lyxopyranonucleoside Analogues

“…Lately, nucleosides bearing a six-membered carbohydrate moiety have been evaluated for their potential antiviral [9 -11], antioxidant [12], and antibiotic [13] properties and as building blocks in nucleic acid synthesis [14,15]. Insertion of an unsaturation in the 29,39-position of the sugar moiety of the aforementioned nucleosides, distinguishes this ring system from common six-membered rings [16] and allows to categorize the cyclohexene ring as a bioisoster of a saturated furanose ring.…”

Efficient synthesis of exomethylene- and keto-exomethylene-d-glucopyranosyl nucleoside analogs as potential cytotoxic agents

“…Lately, nucleosides containing pyranosyl rings have been synthesized along with their analogs in order to develop antitumor, 7,8 antiviral, [9][10][11][12][13] antioxidant, 14 and antimicrobial reagents. 15 Experimental data also revealed that human poly(A)-specific ribonuclease 16 and glycogen phosphorylase 17 are among the molecular targets of these compounds.…”