Antioxidant activity of a new phenolic glycoside from Lagenaria siceraria Stand. fruits

Mohan, Rahul; Birari, Rahul; Karmase, Aniket; Jagtap, Sneha; Bhutani, K. K.

doi:10.1016/j.foodchem.2011.10.063

Cited by 48 publications

(34 citation statements)

References 38 publications

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“…The antioxidant properties of quercetin, that is the capability to quench the ROS involved in a number of pathologies , are well known . A widely employed method to evaluate the antioxidant power of a material is based on the determination of its RSA by means of 1,1‐diphenyl‐2‐picryl‐hydrazyl (DPPH • ) assay . The assay is based on the scavenging action of the antioxidant, which donates hydrogen to DPPH • forming the corresponding hydrazine and provoking a reduction of the characteristic DPPH • absorption band around 515 nm.…”

Section: Resultsmentioning

confidence: 99%

Quercetin and alendronate multi‐functionalized materials as tools to hinder oxidative stress damage

Forte

Torricelli

Boanini

et al. 2017

J Biomedical Materials Res

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In spite of its remarkable anti-oxidant, anti-inflammatory, anti-cancer properties and its possible inhibition activity towards bone resorption, quercetin therapeutic use is limited by its poor bioavailability. Herein we developed a new multifunctionalized system for the local administration of quercetin and alendronate, one of the most potent anti-osteoporotic drugs, with the aim to get a material with enhanced properties. To this purpose we loaded quercetin on hydroxyapatite functionalized with alendronate, as well as on hydroxyapatite. Characterization was performed by means of X-ray diffraction, FT-IR and Raman spectroscopies, thermogravimetric and spectrophotometric analyses. Loading of quercetin from hydro-alcoholic solution increased with time and reached a constant value of about 5 weight% on both substrates, without causing significant structural and morphological modifications. Quercetin functionalized materials exhibit relevant anti-oxidant properties, in agreement with their high radical scavenging activity, and a quercetin sustained release in phosphate buffer. In vitro osteoblast and osteoclast co-culture in a microenvironment altered by oxidative stress shows that both alendronate and quercetin significantly reduce osteoclast viability, whereas they are able to counteract the negative effect of oxidative stress on osteoblast viability and differentiation, suggesting that their relative amount in the functionalized materials can be utilized to tailor bone cells response. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3293-3303, 2017.

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Section: Resultsmentioning

confidence: 99%

Quercetin and alendronate multi‐functionalized materials as tools to hinder oxidative stress damage

Forte

Torricelli

Boanini

et al. 2017

J Biomedical Materials Res

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“…Two sterols i.e., fucosterol and campesterol, aerpenebyonolic acid (an allergic compounds, flavones-c glycosides, ribosome inactivating protein) .Lagenin (antiproliferative, mmunosuppressive, antifertility). 6 reported a new phenolic glycoside from fruit. They are widely used in Ayurveda and other folk medicines; traditionally used for its cardioprotective, cardiotonic, general tonic, diuretic, aphrodisiac, antidote to certain poisons, scorpion strings, alternative purgative, scorpion strings, and cooling effects.…”

Section: Sumitra Et Al:antioxidant Activity Of Lagenaria Sicerariamentioning

confidence: 99%

Antioxidant and metal chelating activities of Lagenaria siceraria (Molina) Standl peel, pulp and aerial parts in relation to their total phenol and flavonoid content

Chanda¹,

Moteriya²,

Padaliya³

et al. 2015

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Objective: The aim of the present study was to evaluate the antioxidant activity and total phenol and flavonoid content of different parts (peel, pulp and aerial parts) of Lagenaria siceraria. Method: Successive extraction was done by cold percolation method using solvents of different polarity viz. petroleum ether, toluene, ethyl acetate, acetone, water. Total phenol content was determined by Folin-Ciocalteu's reagent method and flavonoid was determined by aluminium chloride colorimetric method. The antioxidant assays evaluated were 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, 2, 2'-Azino-bis-(3-ethyl) benzothiazoline-6-sulfonic acid (ABTS) radical cation scavenging activity and Ferric reducing antioxidant power. Results: L. siceraria peel possessed maximum phenol and flavonoid content in acetone and toluene extracts respectively. FRAP was maximum in acetone extract of peel. The peel extract demonstrated stronger DPPH activity with IC 50 value of 111 µg/ml followed by pulp extract. The same extract was effective in scavenging ABTS radical with an IC 50 value of 39 µg/ml while other parts were ineffective. Conclusion: This work demonstrated good antioxidant activity of L. siceraria vegetable cultivated in India and recommends that the peel of this vegetable may be of interest from a functional point of view as a major source of natural antioxidant.

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“…fruit is known to contain bonded phenolics such as glycosides of 4-hydroxymethyl phenol and 4-hydroxymethyl catechol. 12 During the process of refluxing with water hydrolysis 1 ml sample=standard þ1 ml ABTS ð20 mMÞ þ1 ml azide ð0:5 MÞ 9 = ; /10 ml ! Nitrous oxide purging pulse / decay monitoring at 655 nm of glycosides would occur, releasing free phenolics, and thereby increasing the phenolic content and radical scavenging ability of the decoctions.…”

Section: Discussionmentioning

confidence: 99%

Higher antioxidant activity in decoction than raw fruit parts of Lagenaria siceraria (Mol.) Standley as determined by pulse radiolysis

Joshi

Kulkarni

Joag

2013

Free Radicals and Antioxidants

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a b s t r a c tAntioxidant activity of decoctions and fresh juice samples of raw fruit parts of Lagenaria siceraria (Mol.) Standely, (L.S.), viz., fruit pulp, whole fruit and fruit skin, has been evaluated in terms of radical scavenging ability by pulse radiolysis method and phenolic content by FolineCiocalteu assay. The decay of ABTS À radical anion generated by pulse radiolysis has been monitored in presence of samples. The trend in the radical scavenging ability of six samples recorded in terms of ascorbic acid equivalent (AAE) values (4.650e41.230 AAE mg/g fresh weight) have been found to correlate well with the trends in phenolic content of these samples expressed as gallic acid equivalent (GAE) values (0.417e2.000 GAE mg/g fresh weight). The result also shows that the antioxidant activity of decoctions of all the three fruit parts is higher, apparent from their higher AAE and GAE values than the corresponding fresh juice samples.

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Antioxidant activity of a new phenolic glycoside from Lagenaria siceraria Stand. fruits

Cited by 48 publications

References 38 publications

Quercetin and alendronate multi‐functionalized materials as tools to hinder oxidative stress damage

Quercetin and alendronate multi‐functionalized materials as tools to hinder oxidative stress damage

Antioxidant and metal chelating activities of Lagenaria siceraria (Molina) Standl peel, pulp and aerial parts in relation to their total phenol and flavonoid content

Higher antioxidant activity in decoction than raw fruit parts of Lagenaria siceraria (Mol.) Standley as determined by pulse radiolysis

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