Antioxidant Activity of a Medicinal Plant Extract from the Brazilian Forest: Myracrodruon Urundeuva

Machado, Aryane Flauzino; Pieroni, Laís Goyos; Iano, Flávia Godoy; Dokkedal, Anne Lígia; Oliveira, Rodrigo Cardoso de

doi:10.1016/j.freeradbiomed.2014.10.270

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“…The DPHH model demonstrated that HELMu and HEBMu exerted significant antioxidant activity with IC 50 = 4.8 and 7.0 µg/ml, respectively. Similar results were found by Machado et al (2014) for M. urundeuva with the same method, wherein found IC 50 < 4.0 μg/ml for alcoholic extracts, emphasizing the strong antioxidant activity of this specie. Recent studies have shown that free radicals are responsible for mechanisms that cause inflammation and pain, and that high levels of reactive oxygen species (ROS) can induce pain.…”

Section: Discussionsupporting

confidence: 85%

Comparative studies between the chemical constituents and biological properties of the extracts from the leaves and barks of Myracrodruon urundeuva Fr. All.

Mota¹,

Royo²,

Fonseca³

et al. 2015

J. Med. Plants Res.

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The present study describes the comparation between the chemical constituents and biological properties of leaves and barks of Myracrodruon urundeuva for proposing the medicinal use of the plant from leaves, avoiding the degradation by remotion of the barks. The results of chromatographic profile of the hydroalcoholic extracts and fractions of leaves and barks showed similarities in the composition of the phytoconstituents, with variation for some of them that are in greater quantity of the bark extracts. The hydroalcoholics extracts from leaves (HELMu) and barks (HEBMu) exhibited promising 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (IC 50 = 4.8 and 7.0 µg/ml, respectively), comparable to gallic acid (IC 50 = 4.8 µg/ml). No significant cytotoxicity was observed in the concentrations evaluated (IC 50 > 400 μg/ml). The HEBMu exhibited greater nociceptive activity than HELMu, however HELMu was more active against oral pathogens. This study provides support for the use of the leaves in traditional medicine instead of bark.

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Section: Discussionsupporting

confidence: 85%