Antioxidant activity, neuroprotective properties and bioactive constituents analysis of varying polarity extracts from Eucalyptus globulus leaves

Abstract

Eucalyptus globulus is employed as herbal tea and therapeutical purposes. In this work, it is investigated for first time the neuroprotective activities, based on antioxidant properties, of varying polarity extracts (acetone, ethanol and methanol) from E. globulus leaves and elucidate their main bioactive constituents. Methanol and acetone extracts contained the highest phenolic compounds amount and chlorogenic acid was the major compound identified by UPLC-ESI-MS/MS. Moreover, the three tested extracts showed significant antioxidant properties, varying their potency depending on the in vitro technique used. Furthermore, E.globulus extracts were effective in ameliorating HO-induced oxidative stress by increasing cell viability, GSH levels and antioxidant enzymes activity and, by decreasing ROS production and lipid peroxidation levels in SH-SY5Y cells. Taken together, E.globulus leaves extracts could be used as raw material for food and pharmaceutical supplements for their high content in antioxidant compounds with health benefits properties against oxidative stress.

Variability in the Qualitative and Quantitative Composition and Content of Phenolic Compounds in the Fruit of Introduced American Cranberry (Vaccinium macrocarpon Aiton)

“…The variability in the qualitative and quantitative composition and content of phenolic compounds in American cranberry fruit samples was evaluated using ultra performance liquid chromatography-mass spectrometry by applying the technique described and validated by Gonzalez–Burgos et al (2018) [ 60 ]. Mass spectrometry parameters for the analysis of phenolic compounds are presented in Table 2 .…”

Variability in the Content of Phenolic Compounds in Plum Fruit

“…We did not find any data on the evaluation of the qualitative and quantitative content of quinic acid in plum fruit samples mentioned in scientific literature. However, scientific literature contains data about studies on chlorogenic acid and neochlorogenic acid in plum fruit samples [18,19,30].…”

Antimicrobial Activity of Several Cineole-Rich Western Australian Eucalyptus Essential Oils

“…The leaf extracts, including the essential oil, are currently widely used in perfumery and cosmetic products and to a lesser extent as a therapeutic agent. The current medicinal use is based on the range of biological effects exhibited by the oils in vitro, including antioxidant [7], anti-inflammatory, analgesic [8], and antimicrobial activities [9,10,11,12,13]. Clinical trials with Eucalyptus oil and the major component 1,8-cineole (eucalyptol) have been performed to evaluate their efficacy in the treatment of a diverse range of conditions and diseases, including respiratory disorders [14,15], oral hygiene [16], and head lice infestation [17].…”