Antioxidant activity-guided separation of coumarins and lignan from Melicope glabra (Rutaceae)

Kassim, Nur Kartinee; Rahmani, Mawardi; Ismail, Amin; Sukari, Mohd Aspollah; Ee, Gwendoline Cheng Lian; Nasir, Nadiah Mad; Awang, Khalijah

doi:10.1016/j.foodchem.2013.01.108

Cited by 81 publications

(63 citation statements)

References 25 publications

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“…Coumarin is composed of a benzopyran-d-lactone skeleton 1 and exhibits a large number of bioactivities. 2,3 When the coumarin acts as a substituent, it can also increase the bioactivity of the whole molecule.…”

mentioning

confidence: 99%

Activity of coumarin–oxadiazole-appended phenol in inhibiting DNA oxidation and scavenging radical

Gong

Liu

2015

Tetrahedron Letters

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mentioning

confidence: 99%

Activity of coumarin–oxadiazole-appended phenol in inhibiting DNA oxidation and scavenging radical

Gong

Liu

2015

Tetrahedron Letters

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“…18 The evaluation of scavenging activity was performed by following the Kassim and Rahmani method with some modifications. 20 Briefly, 20 μL of the sample dissolved in DMSO (3.125-200 μM) was added to 96 well plates and 180 μL DPPH (140 μM) was applied to each well. DMSO was used as a negative control.…”

Section: Methodsmentioning

confidence: 99%

Phytochemical Studies of Korean Endangered Plants: A New Flavone from Rhododendron brachycarpum G.Don

Zhou¹,

Li²,

Kim³

et al. 2013

Bulletin of the Korean Chemical Society

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“…Total phenolic content was carried out according to the method described by Kassim et al [28] with minor modifications. The stock solution of 1000 ppm of the tested sample and standard Gallic acid was prepared.…”

Section: Total Phenolic Content (Tpc)mentioning

confidence: 99%

“…The DPPH free radical scavenging assay was conducted based on method reported by Kassim et al [28] with minor modifications. 2000 μM of DPPH reagent was prepared by dissolving 0.8 mg of DPPH in 1 mL of MeOH.…”

Section: Dpph Radical Scavenging Assaymentioning

confidence: 99%

Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae)

Salleh¹,

Razak²,

Ahmad³

2017

mpj

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Phytochemicals and biological activities of the leaves of Macaranga hosei and Macaranga constricta have been studied. Fractionation and purification of the extracts of M. hosei afforded two triterpenoids, lupenone (1) and β-sitostenone (2) and two flavonoids, 5-hydroxy-7,4'-dimethoxyflavone (3) and 5-hydroxy-6,7,4'-trimethoxyflavone (4). Three triterpenoids characterized as taraxerone (5), taraxerol (6) and β-amyrin (7) were isolated from M. constricta. The structures of these compounds were established by analysis of their spectroscopic data, as compared to that of reported compounds. Biological activities which include antibacterial, α-glucosidase inhibition and antioxidant were also carried out. The antibacterial activities have demonstrated that all extracts and isolated compounds exhibited weak inhibition against the tested bacterial strains with MIC value exceeded 500 μg/mL. Evaluation of α-glucosidase inhibition activity using ρ-nitrophenyl-ρ-D-glucopyranosidase on extracts exhibited α-glucosidase inhibitory potential. The most potent α-glucosidase activity was exhibited by the petroleum ether extract of M. hosei with inhibitory concentration at 50% (IC 50 ) of 25.3 ppm compared with quercetin (4.5 ppm) and acarbose (12.6 ppm). The antioxidant activity was conducted through DPPH radical scavenging activity and total phenolic content. All the extracts displayed positive results and the methanol extract of M. hosei displayed the highest scavenging activity with scavenging concentration at 50% (SC 50 ) value of 25.8 ppm. The methanol extract of M. hosei also gave the highest total phenol content with 347.7 mg GAE/g.

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Antioxidant activity-guided separation of coumarins and lignan from Melicope glabra (Rutaceae)

Cited by 81 publications

References 25 publications

Activity of coumarin–oxadiazole-appended phenol in inhibiting DNA oxidation and scavenging radical

Activity of coumarin–oxadiazole-appended phenol in inhibiting DNA oxidation and scavenging radical

Phytochemical Studies of Korean Endangered Plants: A New Flavone from Rhododendron brachycarpum G.Don

Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae)

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