Antioxidant activity evaluation of rosemary ethanol extract and their cellular antioxidant activity toward HeLa cells

Nie, Ji-Yu; Li, Rong; Wang, Ying; Tan, Jin; Tang, Shu‐Hua; Jiang, Zi‐Tao

doi:10.1111/jfbc.12851

Cited by 21 publications

(14 citation statements)

References 44 publications

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“…The rosemary powder provided 8 mg of rosmarinic acid, the main component, daily. Although 1,8-cineole, carnosic acid, and luteolin have been reported to be in rosemary essential oils [21] and ethanol extracts [10,22], these were not detected in our rosemary hot-water extract.…”

Section: Test Foodscontrasting

confidence: 68%

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Effects of Continuous Intake of Rosemary Extracts on Mental Health in Working Generation Healthy Japanese Men: Post-Hoc Testing of a Randomized Controlled Trial

et al. 2020

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We previously performed a 4 week interventional trial that suggested that continuous intake of rosemary extract improves the mood states, fatigue, and cognitive function of working generation healthy adult Japanese men. However, the severity of depression in participants in our previous study was relatively mild. Therefore, in the present study, a post-hoc analysis of our previous study was conducted, limited to participants whose total mood disturbance (TMD) scores, which indicate greater mood disturbance, were above the median at baseline, to evaluate whether rosemary extract was effective for individuals with poor mental health. Following the intervention, the scores of TMD and “Confusion-Bewilderment” were significantly decreased (both p < 0.05), and scores of “Vigor-Activity” were significantly increased in the rosemary group (n = 8) compared with those in the control group (n = 13; p < 0.01). When comparing the scores from pre- and post-intervention, significant improvements in “Tension-Anxiety”, “Vigor-Activity”, “Fatigue on awakening”, “Daytime sleepiness”, and “Psychomotor speed” were observed in the rosemary group only (all p < 0.05). Based on these results, it was expected that rosemary extracts were effective for improving the mental energy and sleep quality of work-age men with poor mental health.

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Section: Test Foodscontrasting

confidence: 68%

“…Rosemary essential oils and extracts obtained by ethanol extraction include carnosic acid, luteolin, and the aroma component 1.8-cineole [10,21,22]. It is believed these ingredients also improve emotion and sleep quality [42,43]; however, these components were not detected in our rosemary hot-water extract.…”

Section: Discussionmentioning

confidence: 80%

Effects of Continuous Intake of Rosemary Extracts on Mental Health in Working Generation Healthy Japanese Men: Post-Hoc Testing of a Randomized Controlled Trial

et al. 2020

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“…The solutions of 50 mg/ml EOSA, 1 × 10 –2 mol/L DPPH, 1.0 mol/L ferrous sulfate, 15% hydrogen peroxide, and 3.85 mg/ml ABTS were prepared according to the previous works of literature (Jiang et al., 2013; Nie et al., 2019; Zhao et al., 2017). The working solutions were then obtained by appropriately diluting the relative stock solutions.…”

Section: Methodsmentioning

confidence: 99%

Screening of radical scavenging activity and chemical constituents of the essential oil from star anise by ultra‐fast GC electronic nose coupled with DPPH, OH, and ABTS assays

Nie

et al. 2020

J Food Process Preserv

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A sensitive and selective method of ultra‐fast GC electronic nose (E‐nose) coupled with chemical methodology was developed for both identifying the chemical constituents of essential oil from star anise (EOSA) and the screening of the radical scavenging activity of each compound in EOSA quickly without the isolation of monomers by comparing the change of the chromatographic peak area of every component in EOSA before and after the reaction with the free radicals. The results showed the main components of EOSA were anethole (36.42%), limonene (20.77%), α‐terpinene (6.51%), and α‐phellandrene(5.61%). Among all chemical components, p‐menthatriene showed the strongest scavenging ability both in 1,1'‐diphenyl‐2‐picrylhydrazine (DPPH) and hydroxyl (OH) radicals, and p‐cymenene showed the strongest scavenging ability in 2,2'‐azino‐bis(3‐ethyl‐benzothiazoline‐6‐sulphonate) (ABTS) radical, with scavenging rates of 93.00 ± 0.56%, 79.50 ± 0.78%, and 70.80 ± 0.32%, respectively. The reliability and feasibility of using E‐nose to identify chemical constituents of EOSA were verified by gas chromatography‐tandem mass spectrometry(GC‐MS/MS). Practical applications The essential oils are the complex mixtures and important constituents in natural edible spices. How to evaluate and screen the radical scavenging activity of each component in the mixtures is a very challenging project. The traditional chemical methods are mainly used to evaluate total radical scavenging activity and antioxidant activity of essential oils. The compounds in the mixture need to be separated into individuals in advance if we want to know the bioactivity of each component and their radical scavenging activity in the past. The paper has developed a simple and convenient ultra‐fast GC E‐nose method. This method can not only quickly identify the chemical components of essential oil from star anise, but also quickly evaluate the radical scavenging activity of each compound in the essential oil from star anise. The proposed method can be applied to almost any other essential oils and volatile mixtures.

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“…provide health benefits to consumers (Li, Gao, & Lou, 2019). A recent report also showed that glycosides were the major polyphenolic compounds in the bioactive ethanolic extract of rosemary leaves (Nie et al, 2019). Among all the compounds, chlorogenic acid and quercetin are considered as potent antioxidative, anti-inflammatory, and anti-carcinogenic agents (Silinsin & Bursal, 2018).…”

Section: Total Polyphenol Content (Tpc) Total Flavonoid Content and Identification Of Major Polyphenolic Compoundsmentioning

confidence: 99%

Chemical composition and in vitro antioxidant properties of water‐soluble extracts obtained from Bangladesh vegetables

et al. 2020

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The aim of this study was to evaluate the nutritional value and antioxidant properties of aqueous extracts of some Bangladesh vegetables using fruits of ash gourd, bitter gourd, brinjal, okra, ridge gourd, snake gourd, and leaves of Indian spinach, kangkong, and stem amaranth. Proximate composition showed that the dried extracts were composed mainly of crude protein (14.6%-46.7%) and non-fibre carbohydrates (26.4%-53.5%). With the exception of stem amaranth, all the extracts had >40% DPPH radical scavenging ability at 0.5 mg/ml. In contrast metal chelation was lower, except in Indian spinach with ~46%. The ferric reducing antioxidant power (FRAP) was highest for the kangkong (10.9 mM Fe 3+ reduced), which is similar to the 9.9 mM for butylated hydroxytoluene (BHT). All the extracts suppressed linoleic acid oxidation better than BHT within the first 5 days of the incubation period. We conclude that the Indian spinach, kangkong, and okra could be considered as the most promising sources of antioxidant compounds. Practical applications Vegetables are commonly consumed as part of a regular diet but the high water and fiber contents usually mean that large quantities are required to provide long-term health benefits. Therefore, in this work, aqueous extracts of nine Bangladesh vegetables were prepared to provide a more concentrated form of nutrients and bioactive compounds. The extracts had strong nutritional value based on the high contents of crude protein, potassium, iron, and non-fibre carbohydrates. The high content of polyphenolic compounds in the extracts can also provide health benefits, which was demonstrated through strong free radical scavenging, metal chelation, ferric iron reduction, and inhibition of linoleic acid oxidation. These vegetable extracts have the potential to be used as sources of bioactive compounds to prevent or treat noncommunicable diseases that are associated with high oxidative stress.

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Antioxidant activity evaluation of rosemary ethanol extract and their cellular antioxidant activity toward HeLa cells

Cited by 21 publications

References 44 publications

Effects of Continuous Intake of Rosemary Extracts on Mental Health in Working Generation Healthy Japanese Men: Post-Hoc Testing of a Randomized Controlled Trial

Effects of Continuous Intake of Rosemary Extracts on Mental Health in Working Generation Healthy Japanese Men: Post-Hoc Testing of a Randomized Controlled Trial

Screening of radical scavenging activity and chemical constituents of the essential oil from star anise by ultra‐fast GC electronic nose coupled with DPPH, OH, and ABTS assays

Chemical composition and in vitro antioxidant properties of water‐soluble extracts obtained from Bangladesh vegetables

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