Antioxidant activity and α-glucosidase inhibitory potential of onion (Allium cepa L.) extracts

Kim, Myung‐Hee; Jo, Sung‐Hoon; Jang, Hae‐Dong; Lee, Mee Sook; Kwon, Young‐In

doi:10.1007/s10068-010-0022-1

Cited by 50 publications

(42 citation statements)

References 22 publications

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“…This could justify why all extracts studied here were more active against this enzyme than acarbose. Furthermore, the nature of some extract constituents (phenolics, flavonoids and their glycosides) is in accordance with previous reported works as being effective inhibitors of α-glucosidases [26-29]. For example, water extract of P. kotschyi leaves was evaluated by Udeme et al on blood glucose in alloxan-induced diabetic albino wistar rats [3].…”

Section: Discussionsupporting

confidence: 82%

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In vitro biological effects of two anti-diabetic medicinal plants used in Benin as folk medicine

Bothon

Débiton

Avlessi

et al. 2013

BMC Complement Altern Med

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BackgroundExtracts from Polygonum senegalensis (Polygonaceae) and Pseudocedrela kotschyi (Meliaceae) are two important traditionally used medicinal plants in rural Benin to treat many diseases and notably type 2 diabetes. The aim of the study was to investigate the α-glucosidase inhibition, antioxidant and antibacterial activities of those plants extract: Polygonum senegalensis leaves, and Pseudocedrela kotschyi root.MethodsHydro-alcoholic (50%) extracts were analyzed for their phytochemical content and tested for their inhibition potency on α-glucosidase from Saccharomyces cerevisiae. Antioxidant activities were assessed using the DPPH, ORAC, FRAP and DCFH-DA (cell based) assay. Finally, the antibacterial activity was evaluated using MIC determination on four Gram-positive cocci (Bacillus subtilis, Clostridium difficile, Enterococcus faecalis, Staphylococcus aureus), three Gram-negative bacilli (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae), and the yeast Candida albicans.ResultsEach extract presented significant α-glucosidase inhibition and antioxidant activities. Polygonum senegalensis leaf extracts were the most active in each in vitro assay with an IC50 = 1.5 μg/ml for α-glucosidase inhibition and an IC50 = 6.8 μg/ml for DPPH scavenging, - 4.5 μmol Fe II/g of dry matter - 9366 μmol Trolox / g DW - for FRAP and ORAC values, respectively. IC50 = 2.3 μg GA / ml for DCFH-DA assay. Concerning its antibacterial activity, a growth inhibitory effect was observed only against three Gram negative bacilli: B. subtilis, E. faecalis, S. aureus and the yeast C. albicans at high concentration.ConclusionThe results showed that the semi alcoholic extract of the two studied plants possess α-glucosidase inhibitory activity, antioxidant potency, and low antibacterial effect.

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Section: Discussionsupporting

confidence: 82%

“…Various in vitro assays have shown that many plant polyphenols possess carbohydrate hydrolyzing enzyme inhibitory activities [26,28,29]. Since these molecules exert antioxidant effect, it is likely that antioxidant and α-glucosidase inhibitory properties should come from polyphenolic contents.…”

Section: Discussionmentioning

confidence: 99%

In vitro biological effects of two anti-diabetic medicinal plants used in Benin as folk medicine

Bothon

Débiton

Avlessi

et al. 2013

BMC Complement Altern Med

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“…The absorption of glucose obtained by a-glucosidase may result in a rapid rise in blood glucose levels in non-insulin dependent diabetes mellitus patients (Kim, Jo, Jang, Lee, & Kwon, 2010). Moreover, hyperglycaemia that increases superoxide production by the mitochondria may initiate diabetic complications (Brownlee, 2005).…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of rosmarinic acid, methyl rosmarinate and pedalitin isolated from Rabdosia serra (MAXIM.) HARA as inhibitors of tyrosinase and α-glucosidase

et al. 2011

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“…To determine the inhibition of the α ‐glucosidase of Saccharomyces cerevisiae by Taxus fruit extracts, a previously reported method was used with some modifications . PNPG was used as a substrate.…”

Section: Methodsmentioning

confidence: 99%

Chemical Components, Biological Activities, and Toxicological Evaluation of the Fruit (Aril) of Two Precious Plant Species from Genus Taxus

Pan

Zhang

et al. 2017

Chemistry & Biodiversity

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The fruit (aril) of the endangered genus Taxus plants is an abandoned herbal resource. Traditionally, people enthusiastically focus on its bark, its renewable, tremendous arils fall into the soil with seeds after they are mature. The present research investigated the fruit of two species from the genus Taxus, Taxus chinensis var. mairei, and Taxus media, with regards to their antioxidant and antihyperglycaemic activities, safety, and bioactive constituents. Results showed that T. chinensis var. mairei and T. media both had certain biological activities with T. chinensis var. mairei better in antioxidant activity and T. media better in antihyperglycaemic activity. Correlation analysis revealed that the differences in bioactivities depended on content of their mainly chemical components. The mice acute oral toxicity test indicated that the methanol extracts of the two biotypes of Taxus were safe. And nineteen compounds were tentatively assigned from the two varieties, via tandem mass spectrometry using a LC-ESI-Q-TOF-MS instrument, which included phenols, flavonoids, and terpenes. These results indicate a possible application of Taxus fruit extracts in various fields like in food industry, however, this still needs further investigations.

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Antioxidant activity and α-glucosidase inhibitory potential of onion (Allium cepa L.) extracts

Cited by 50 publications

References 22 publications

In vitro biological effects of two anti-diabetic medicinal plants used in Benin as folk medicine

In vitro biological effects of two anti-diabetic medicinal plants used in Benin as folk medicine

Comparative evaluation of rosmarinic acid, methyl rosmarinate and pedalitin isolated from Rabdosia serra (MAXIM.) HARA as inhibitors of tyrosinase and α-glucosidase

Chemical Components, Biological Activities, and Toxicological Evaluation of the Fruit (Aril) of Two Precious Plant Species from Genus Taxus

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