Antioxidant Activity and Role of Culture Condition in the Optimization of Red Pigment Production by Talaromyces purpureogenus KKP Through Response Surface Methodology

Keekan, Kishor Kumar; Hallur, Sweta; Modi, Prashant Kumar; Shastry, Rajesh P.

doi:10.1007/s00284-020-01995-4

Cited by 22 publications

(15 citation statements)

References 34 publications

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“…•Rice and peptone are optimum carbon and nitrogen sources, respectively, to produce citrinin-free red pigments by M. ruber OMNRC45 under submerged fermentation conditions [89].…”

Section: Red Azaphilonesmentioning

confidence: 99%

“…Another interesting result was the potent cytotoxic activity showed by the dimeric azaphilones ( 89) and ( 90) against five different human cell lines. (89) showed more potent cytotoxicity against MGC-803 than cisplatin and possessed a unique 6/4/6 ring system suggesting the new ring may play an important role in cytotoxicity [57].…”

Section: Biological Activities Of Azaphilonesmentioning

confidence: 99%

“…Therefore, a big challenge in pigments production is to obtain pure extracts, containing fewer substances and, preferably, with only one color [ 19 ]. Figure 12 presents some fungal species and associated fermentative parameters that resulted in the production of yellow [ 66 , 80 , 81 , 82 , 83 , 84 ], orange [ 14 , 85 ] or red [ 14 , 79 , 85 , 86 , 87 , 88 , 89 ] pigments. However, in most of the works, yellow, orange and red azaphilones are produced simultaneously (cocktail pigments phenomenon) in different proportions.…”

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

“…Figure 12.Conditions reported for color-directed production of yellow, orange and red azaphilones[14,67,[80][81][82][83][84][85][86][87][88][89][90].…”

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confidence: 99%

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Recent Findings in Azaphilone Pigments

Pimenta

Gomes

Cardoso

et al. 2021

JoF

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Filamentous fungi are known to biosynthesize an extraordinary range of azaphilones pigments with structural diversity and advantages over vegetal-derived colored natural products such agile and simple cultivation in the lab, acceptance of low-cost substrates, speed yield improvement, and ease of downstream processing. Modern genetic engineering allows industrial production, providing pigments with higher thermostability, water-solubility, and promising bioactivities combined with ecological functions. This review, covering the literature from 2020 onwards, focuses on the state-of-the-art of azaphilone dyes, the global market scenario, new compounds isolated in the period with respective biological activities, and biosynthetic pathways. Furthermore, we discussed the innovations of azaphilone cultivation and extraction techniques, as well as in yield improvement and scale-up. Potential applications in the food, cosmetic, pharmaceutical, and textile industries were also explored.

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“…•Rice and peptone are optimum carbon and nitrogen sources, respectively, to produce citrinin-free red pigments by M. ruber OMNRC45 under submerged fermentation conditions [89].…”

Section: Red Azaphilonesmentioning

confidence: 99%

Section: Biological Activities Of Azaphilonesmentioning

confidence: 99%

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

“…Figure 12.Conditions reported for color-directed production of yellow, orange and red azaphilones[14,67,[80][81][82][83][84][85][86][87][88][89][90].…”

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confidence: 99%

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Recent Findings in Azaphilone Pigments

Pimenta

Gomes

Cardoso

et al. 2021

JoF

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“…Hong Qu Huangjiu is unique because its production involves Hong Qu (saccharification starter), which is inoculated with Monascus spp., introducing numerous pigments and enzymes ( Feng et al, 2012 ; Patakova, 2013 ; Vendruscolo et al, 2016 ; Keekan et al, 2020 ). Monascus pigments contribute to the unique color and physiological effects of HQW.…”

Section: Introductionmentioning

confidence: 99%

The Potential of Flos sophorae immaturus as a Pigment-Stabilizer to Improve the Monascus Pigments Preservation, Flavor Profiles, and Sensory Characteristic of Hong Qu Huangjiu

et al. 2021

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Hong Qu Huangjiu (HQW) is distinguished by its inclusion of Monascus pigments, meaning that photosensitivity strongly affects the sensory quality of the wine. In this study, the effects of Flos sophorae immaturus (FSI) on the stability of Monascus pigments, the flavor profiles, and the sensory characteristics of HQW were investigated. After sterilization, the addition of FSI increased the preservation rate of Monascus pigments in HQW by up to 93.20%, which could be accounted for by the synergy of rutin and quercetin in FSI. The total content of the volatile flavor compounds in HQW increased significantly as the added amounts of FSI were increased, especially 3-methyl-1-butanol, 2-methyl-1-propanol, and short-chain fatty acid ethyl esters (SCFAEE). Sensory evaluation and partial least-squares regression revealed that the concentration of FSI significantly affected the aroma characteristics of HQW but had little effect on the mouthfeel. The addition of 0.9 mg/mL FSI yielded a satisfactory HQW with high scores in terms of mouthfeel and aroma. The strong correlation between fruit-aroma, full-body, and SCFAEE suggests that FSI might alter the aroma of HQW by enhancing the synthesis of SCFAEE. Summarily, treatment with FSI represents a new strategy for improving the stability of photosensitive pigments and thus adjusting the aroma of HQW or similar beverages.

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