Antioxidant activity and protective effects against oxidative damage of human cells induced by X-radiation of phenolic glycosides isolated from pepper fruits Capsicum annuum L.

Materska, Małgorzata; Konopacka, Maria; Rogoliński, Jacek; Ślosarek, Krzysztof

doi:10.1016/j.foodchem.2014.07.023

Cited by 57 publications

(30 citation statements)

References 36 publications

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“…Researchers found that q3Or showed the highest radioprotective effect, with a 50% reduction in DNA damage compared to controls. Importantly, in this study these substances did not show any toxic effects against human lymphocytes [ 19 ]. The phenolic glycosides were also noted to have excellent antiradical activities [ 19 ].…”

Section: Introductionmentioning

confidence: 88%

“…Phenolic glycosides, which occur naturally in plants, have also been shown to have antioxidant properties [ 19 ]. Materska et al [ 19 ] investigated several phenolic glycosides: sinapoyl-E-glucoside (sEg), quercetin-3- O -rhamnoside-7- O -glucoside (q3Or7Og), quercetin-3- O -rhamnoside (q3Or) and luteolin-7- O -(2-apiosyl)-glucoside (l7O2ag). The authors used human lymphocytes obtained from healthy human donors, and then exposed them to one of the phenolic glycosides before irradiation with X-rays.…”

Section: Introductionmentioning

confidence: 99%

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Radioprotective agents to prevent cellular damage due to ionizing radiation

et al. 2017

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Medical imaging has become a central component of patient care to ensure early and accurate diagnosis. Unfortunately, many imaging modalities use ionizing radiation to generate images. Ionizing radiation even in low doses can cause direct DNA damage and generate reactive oxygen species and free radicals, leading to DNA, protein, and lipid membrane damage. This cell damage can lead to apoptosis, necrosis, teratogenesis, or carcinogenesis. As many as 2% of cancers (and an associated 15,000 deaths annually) can be linked to computed tomography exposure alone. Radioprotective agents have been investigated using various models including cells, animals, and recently humans. The data suggest that radioprotective agents working through a variety of mechanisms have the potential to decrease free radical damage produced by ionizing radiation. Radioprotective agents may be useful as an adjunct to medical imaging to reduced patient morbidity and mortality due to ionizing radiation exposure. Some radioprotective agents can be found in high quantities in antioxidant rich foods, suggesting that a specific diet recommendation could be beneficial in radioprotection.

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Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Radioprotective agents to prevent cellular damage due to ionizing radiation

et al. 2017

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“…Nevertheless, it was not until the nineties when flavonoids started to reach importance thanks to the multiple beneficial effects on human health associated to their consumption. The numerous studies dealing with the bioactive properties of flavonoids have been mainly associated to the reduction of the risk of different types of cancer and cardiovascular diseases [ 4 ], and to their antioxidant, anti-inflammatory and radical-scavenging activity [ 5 ]. The latest investigations on the beneficial effects of flavonoids pointed out the actions of some of them, like quercetin, in anti-diabetic and anti-obesity treatments [ 6 , 7 ], and as protectors of gastric epithelial cells [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of the Effect of Sample Pretreatment and Extraction on the Determination of Flavonoids from Lemon (Citrus limon)

2016

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BackgroundFlavonoids have shown to exert multiple beneficial effects on human health, being also appreciated by both food and pharmaceutical industries. Citrus fruits are a key source of flavonoids, thus promoting studies to obtain them. Characteristics of these studies are the discrepancies among sample pretreatments and among extraction methods, and also the scant number of comparative studies developed so far.ObjectiveEvaluate the effect of both the sample pretreatment and the extraction method on the profile of flavonoids isolated from lemon.ResultsExtracts from fresh, lyophilized and air-dried samples obtained by shaking extraction (SE), ultrasound-assisted extraction (USAE), microwave-assisted extraction (MAE) and superheated liquid extraction (SHLE) were analyzed by LC–QTOF MS/MS, and 32 flavonoids were tentatively identified using MS/MS information. ANOVA applied to the data from fresh and dehydrated samples and from extraction by the different methods revealed that 26 and 32 flavonoids, respectively, were significant (p≤0.01). The pairwise comparison (Tukey HSD; p≤0.01) showed that lyophilized samples are more different from fresh samples than from air-dried samples; also, principal component analysis (PCA) showed a clear discrimination among sample pretreatment strategies and suggested that such differences are mainly created by the abundance of major flavonoids. On the other hand, pairwise comparison of extraction methods revealed that USAE and MAE provided quite similar extracts, being SHLE extracts different from the other two. In this case, PCA showed a clear discrimination among extraction methods, and their position in the scores plot suggests a lower abundance of flavonoids in the extracts from SHLE. In the two PCA the loadings plots revealed a trend to forming groups according to flavonoid aglycones.ConclusionsThe present study shows clear discrimination caused by both sample pretreatments and extraction methods. Under the studied conditions, liophilization provides extracts with higher amounts of flavonoids, and USAE is the best method for isolation of these compounds, followed by MAE and SE. On the contrary, the SHLE method was the less favorable to extract flavonoids from citrus owing to degradation.

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“…In this context, lipid peroxidation induced by ascorbic acid and ferrous sulfate in erythrocyte membranes was found to be inhibited by active principles of C. annuum, suggesting a defensive mechanism against free radicals and a protective effect on erythrocyte integrity [83]. The phenolic glycosides isolated from C. annuum fruit and their aglycones were examined according to their antioxidant activities and their protective abilities against Xradiation on human cell lymphocytes, showing that phenolic glycosides present higher X-ray radioprotective activities than their aglycones [84]. Another study examined the antioxidant properties of different fraction of methanolic extract of unripe fruit part of the A review of Capsicum spp.…”

Section: Antioxidant Activitymentioning

confidence: 98%

Potential Phytopharmacy and Food Applications of Capsicum spp.: A Comprehensive Review

Salehi

Hernández‐Álvarez

Contreras

et al. 2018

Natural Product Communications

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Capsicum genus (Solanaceae) is native to the Americas. Today, it is an important agricultural crop cultivated around the world, not only due to its economic importance, but also for the nutritional value of the fruits. Among their phytochemical constituents, capsaicinoids are characteristic and responsible of the pungency of sharp-tasting cultivars. Moreover, Capsicum and capsaicinoids (mainly, capsaicin) have been largely studied because of their health benefits. Thus, this study reviews the scientific knowledge about Capsicum spp. and their phytochemicals against cancer, diabetes, gastrointestinal diseases, pain, and metabolic syndrome, as well as their antioxidant and antimicrobial activity. These bioactivities can be the basis of the formulation of functional ingredients and natural preservatives containing Capsicum extracts or isolated compounds.

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Antioxidant activity and protective effects against oxidative damage of human cells induced by X-radiation of phenolic glycosides isolated from pepper fruits Capsicum annuum L.

Cited by 57 publications

References 36 publications

Radioprotective agents to prevent cellular damage due to ionizing radiation

Radioprotective agents to prevent cellular damage due to ionizing radiation

Comparative Study of the Effect of Sample Pretreatment and Extraction on the Determination of Flavonoids from Lemon (Citrus limon)

Potential Phytopharmacy and Food Applications of Capsicum spp.: A Comprehensive Review

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