Antioxidant activity and protective effect of wheat germ peptides in an in vitro celiac disease model via Keap1/Nrf2 signaling pathway

Wheat peptide alleviates DSS-induced colitis by activating the Keap1–Nrf2 signaling pathway and maintaining the integrity of the gut barrier

“…Wheat germ peptides have been reported to alleviate gliadin P31–43 peptide-induced Caco-2 cell damage by activating Nrf2. 31…”

“…Wheat germ peptides have been reported to alleviate gliadin P31-43 peptide-induced Caco-2 cell damage by activating Nrf2. 31 We examined the protein expression levels of Keap1 and Nrf2 by IF and WB (Fig. 8A-C).…”

A review of the functional activities of chia seed and the mechanisms of action related to molecular targets

“…Inhibition of MCP-1 gene expression alleviates inflammation and improves the arterial blood status. 99 It has been proved that the bioactive peptides obtained from rice, 100 wheat germ, 101,102 corn, 103 asparagus gum, 104 milk, 105 porcine bone, 106 red sea flatfish, 107 Hippocampus abdominalis 108 and carp skin 109,110 are powerful in regulating body dysfunction. The effect on alleviating oxidative damage and fatigue, protecting the liver, promoting muscle cell differentiation and mitochondrial development, and preventing osteoporosis were deeply explored.…”

Dimethyl Fumarate and Intestine: From Main Suspect to Potential Ally against Gut Disorders

“…The protective role of Nrf2 was also demonstrated in the context of CeD. Particularly, wheat germ peptides exerted a beneficial role in an in vitro model of CeD through the activation of the Nrf2 pathway [ 113 ]; moreover, resveratrol, a well-known Nrf2 inducer, led to a reduction in oxidative stress and epithelial cell damage in in vitro and in vivo CeD models [ 114 ]. Similar results were also obtained in a gliadin-induced enteropathy mouse model using conjugated linoleic acid [ 115 ].…”