Antioxidant Activity and Neuroprotective Role of Docosahexaenoic Acid (DHA) Supplementation in Eye Diseases That Can Lead to Blindness: A Narrative Review

Lafuente, María José; González‐Herrero, María Elena Rodríguez; Villadóniga, Stéphanie Romeo; Domingo, Joan Carles

doi:10.3390/antiox10030386

Cited by 21 publications

(16 citation statements)

References 68 publications

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“…In Ophthalmology, alpha lipoic acid supplementation improved serum SOD activity in AMD patients ( 92 ). Supplementation with high dose DHA showed beneficial effects for patients with diabetic retinopathy, glaucoma and macular edema ( 93 ). Specifically in glaucoma, DHA supplementation increased TAC and decreased MDA and IL6 ( 94 ).…”

Section: Discussionmentioning

confidence: 99%

NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial

et al. 2022

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Oxidative stress plays a major role in the pathogenesis of retinitis pigmentosa (RP). The main goal of this study was to evaluate the effect of 2-year nutritional intervention with antioxidant nutraceuticals on the visual function of RP patients. Secondly, we assessed how nutritional intervention affected ocular and systemic redox status. We carried out a randomized, double-blind, placebo-controlled study. Thirty-one patients with RP participated in the study. RP patients randomly received either a mixture of nutraceuticals (NUT) containing folic acid, vitamin B6, vitamin A, zinc, copper, selenium, lutein, and zeaxanthin or placebo daily for 2 years. At baseline and after 2-year of the nutritional supplementation, visual function, dietetic-nutritional evaluations, serum concentration of nutraceuticals, plasma and aqueous humor concentration of several markers of redox status and inflammation were assessed. Retinal function and structure were assessed by multifocal electroretinogram (mfERG), spectral domain-optical coherence tomography (SD-OCT) and automated visual field (VF) tests. Nutritional status was estimated with validated questionnaires. Total antioxidant capacity, extracellular superoxide dismutase (SOD3), catalase (CAT), and glutathione peroxidase (GPx) activities, protein carbonyl adducts (CAR) content, thiobarbituric acid reactive substances (TBARS) formation (as indicator of lipid peroxidation), metabolites of the nitric oxide (NOX) and cytokine (interleukin 6 and tumor necrosis factor alpha) concentrations were assessed by biochemical and immunological techniques in aqueous humor or/and blood. Bayesian approach was performed to determine the probability of an effect. Region of practical equivalence (ROPE) was used. At baseline, Bayesian analysis revealed a high probability of an altered ocular redox status and to a lesser extent systemic redox status in RP patients compared to controls. Twenty-five patients (10 in the treated arm and 15 in the placebo arm) completed the nutritional intervention. After 2 years of supplementation, patients who received NUT presented better retinal responses (mfERG responses) compared to patients who received placebo. Besides, patients who received NUT showed better ocular antioxidant response (SOD3 activity) and lower oxidative damage (CAR) than those who received placebo. This study suggested that long-term NUT supplementation could slow down visual impairment and ameliorate ocular oxidative stress.

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Section: Discussionmentioning

confidence: 99%

NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial

et al. 2022

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“…In contrast, DHA-derived SPMs are critically important for neuroprotection [18,20]. Likewise, recent evidence shows that consumption of EPA alone is largely associated with a reduction in cardiovascular diseases [21,22], whereas DHA is important for neonatal brain development and mental and cognitive effects [23,24].…”

Section: Are All N−3 Pufas (Ala Sda Epa and Dha) Equally Beneficial For Health?mentioning

confidence: 99%

Omega−3 Polyunsaturated Fatty Acids (PUFAs): Emerging Plant and Microbial Sources, Oxidative Stability, Bioavailability, and Health Benefits—A Review

et al. 2021

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The omega−3 (n−3) polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) acid are well known to protect against numerous metabolic disorders. In view of the alarming increase in the incidence of chronic diseases, consumer interest and demand are rapidly increasing for natural dietary sources of n−3 PUFAs. Among the plant sources, seed oils from chia (Salvia hispanica), flax (Linum usitatissimum), and garden cress (Lepidium sativum) are now widely considered to increase α-linolenic acid (ALA) in the diet. Moreover, seed oil of Echium plantagineum, Buglossoides arvensis, and Ribes sp. are widely explored as a source of stearidonic acid (SDA), a more effective source than is ALA for increasing the EPA and DHA status in the body. Further, the oil from microalgae and thraustochytrids can also directly supply EPA and DHA. Thus, these microbial sources are currently used for the commercial production of vegan EPA and DHA. Considering the nutritional and commercial importance of n−3 PUFAs, this review critically discusses the nutritional aspects of commercially exploited sources of n−3 PUFAs from plants, microalgae, macroalgae, and thraustochytrids. Moreover, we discuss issues related to oxidative stability and bioavailability of n−3 PUFAs and future prospects in these areas.

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“…Омега-3 ПНЖК увеличивают сохранность фоторецепторов, уменьшают повреждение сетчатки, вызванное транзиторной ишемией [36], обеспечивают эффект антиапоптоза, снижают уровень тревоги и депрессии, а также защищают ганглиозные клетки сетчатки от гибели со снижением воспалительного ответа [37] и улучшают зрительные функции [38][39][40].…”

Section:  обсуждениеunclassified

Длительная Нейропротекция Зрительного Нерва После Токсического Поражения Метанолом (Экспериментально-Клинические Наблюдения)

Guzun¹,

Khramenko²,

Коновалова³

et al. 2021

Офтальмология. Восточная Европа

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Проведенное экспериментально-клиническое исследование показывает необходимость и эффективность предложенного комплекса лечебных мероприятий при токсическом (метаноловом) поражении зрительного нерва, направленного на улучшение метаболических процессов и кровообращения, что способствует восстановлению миелиновой оболочки вокруг осевых цилиндров волокон зрительного нерва и, соответственно, ведет к ускорению проведения потенциала действия на возрождение анализа зрительной информации. Курс нейропротекторного лечения включает курсы низкоинтенсивной лазерной терапии сетчатки/ДЗН каждые 6 месяцев с непрерывной поддержкой не менее 3 лет витаминно-антиоксидантным комплексом Нутроф® Форте формулы AREDS, усиленной витамином D3, омега-3 ПНЖК и ресвератролом (1 мг). Thus, the conducted experimental-clinical study shows the necessity and effectiveness of the proposed complex of therapeutic measures for toxic (methanol) damage to the optic nerve, aimed at improving metabolic processes and blood circulation, which contributes to the restoration of the myelin sheath around the axial cylinders of the optic nerve fibers and, accordingly, leads to accelerating the implementation of the action potential for the revival of the analysis of visual information. The course of neuroprotective treatment includes courses of low-intensity laser therapy of the retina / optic nerve disc every 6 months with continuous support with a vitamin-antioxidant complex of the AREDS formula, fortified with vitamin D3, omega-3 PUFA and resveratrol (1 mg) (Nutrof ® Forte), which should be carried out at least 3 years.

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Antioxidant Activity and Neuroprotective Role of Docosahexaenoic Acid (DHA) Supplementation in Eye Diseases That Can Lead to Blindness: A Narrative Review

Cited by 21 publications

References 68 publications

NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial

NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial

Omega−3 Polyunsaturated Fatty Acids (PUFAs): Emerging Plant and Microbial Sources, Oxidative Stability, Bioavailability, and Health Benefits—A Review

Длительная Нейропротекция Зрительного Нерва После Токсического Поражения Метанолом (Экспериментально-Клинические Наблюдения)

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