Antioxidant activity and nephroprotective effect of Lansium parasiticum leaves in doxorubicin-induced rats

Lubis, Muhammad Fauzan; Syahputra, Syahputra; Illian, Didi Nurhadi; Kaban, Vera Estefania

doi:10.29228/jrp.154

Cited by 11 publications

(10 citation statements)

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“…The study involved subjecting cells in the exponential growth phase to serial dilutions of Eav, Gemcitabine (Gem), or a combination of the two for a period of 24 h. The cells did not attain a state of plateau phase within the designated period of incubation. The concentration of a drug that resulted in a 50 % inhibition of cell growth relative to the untreated control was determined as the Fifty Percent Inhibitory Concentration (IC 50 ) ( Hasibuan and Ilyas, 2013 , Lubis et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

The ethyl acetate extract of Vernonia amygdalina leaf ameliorates gemcitabine effect against migration and invasion of PANC-1 cells via down-regulation the VEGF, COX2, and RAS/MEK pathways

Hasibuan,

Keliat,

Lubis

et al. 2024

Saudi Pharmaceutical Journal

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Section: Methodsmentioning

confidence: 99%

The ethyl acetate extract of Vernonia amygdalina leaf ameliorates gemcitabine effect against migration and invasion of PANC-1 cells via down-regulation the VEGF, COX2, and RAS/MEK pathways

Hasibuan,

Keliat,

Lubis

et al. 2024

Saudi Pharmaceutical Journal

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“…The liver tissues obtained from the experimental animals were fixed in 10% phosphate-buffered formalin for a duration of one day. Liver sections with 5 µm thickness were prepared using a cryostat microtome (Leica CM1950, Germany) and subsequently stained with haematoxylin and eosin for microscopic analysis (H&E) [23].…”

Section: Histological Analysismentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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“…Kerusakan dapat berkembang di berbagai jaringan jika antioksidan dalam tubuh lebih sedikit dibandingkan dengan jumlah radikal bebas. Ketika konsentrasi ROS melebihi jumlah antioksidan dalam tubuh manusia, stres oksidatif yang berbahaya terbentuk, yang dapat menyebabkan penyakit kronis (Lubis et al, 2022;Satria et al, 2017).…”

Section: Pendahuluanunclassified

Uji Aktivitas ALT, AST dan Histopatologi Ekstrak Etanol Rimpang Temu Kunci (Boesenbergia rotunda (L.) Mansf) pada Tikus Putih Jantan

Harahap,

Sitorus

2023

jharma

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Experimental research in the field of hepatology on the development of traditional medicine into a potential pharmacological solution to protect the liver from cirrhosis. Accordingly, this study investigated the effect of ethanol extract of temu kunci rhizome on liver cirrhosis. The rats were divided into six groups, the normal control group was given nothing but pellets and sufficient water, the negative control group was given orally CMC-Na 0.5%, 200 mg acetylcysteine (dose converted to rat) was given to the positive control group, and the treatment group was given ethanol extract of temu kunci rhizome doses of 250, 500, 750 mg/kg BW, given daily for 10 days. Then on the 10th day after 1 hour of extract administration, induction was carried out with paracetamol 800 mg/kg BW orally; 16 hours after induction, rats were sacrificed, blood was taken for ALT and AST enzyme examination, then liver organs were taken for histopathological examination. The administration of ethanol extract of temu kunci rhizome can prevent liver damage by reducing ALT and AST enzyme levels in rat blood serum. The best dose in reducing ALT and AST enzymes was produced by giving 500 mg/kg BW of temu kunci rhizome ethanol extract every day for 10 days. At a dose of 500 mg/kg BW ethanol extract of temu kunci rhizome morphologically (evaluation with H&E staining) can also repair liver tissue damaged by paracetamol induction. The development of liver damage can be interpended by using ethanol extract of temu kunci rhizome, so that the status of liver morphology, structure and function of the liver can be maintained.

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Antioxidant activity and nephroprotective effect of Lansium parasiticum leaves in doxorubicin-induced rats

Cited by 11 publications

References 0 publications

The ethyl acetate extract of Vernonia amygdalina leaf ameliorates gemcitabine effect against migration and invasion of PANC-1 cells via down-regulation the VEGF, COX2, and RAS/MEK pathways

The ethyl acetate extract of Vernonia amygdalina leaf ameliorates gemcitabine effect against migration and invasion of PANC-1 cells via down-regulation the VEGF, COX2, and RAS/MEK pathways

Untitled

Uji Aktivitas ALT, AST dan Histopatologi Ekstrak Etanol Rimpang Temu Kunci (Boesenbergia rotunda (L.) Mansf) pada Tikus Putih Jantan

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