Antioxidant activity and hepatoprotective potential of agaro-oligosaccharides in vitro and in vivo

Abstract

Background: Agaro-oligosaccharides derived from red seaweed polysaccharide have been reported to possess antioxidant activity. In order to assess the live protective effects of agaroligosaccharides, we did both in vitro and in vivo studies based on own-made agaro-oligosaccharides, and the structural information of this oligosaccharide was also determined.

Enzymatic production of 3,6-anhydro-l-galactose from agarose and its purification and in vitro skin whitening and anti-inflammatory activities

“…These functions include apoptosis induction, carcinostatic activity, antioxidation, hepatoprotection, immunoregulation, anti-allergy, anti-inflammation, and α-glucosidase inhibition (Chen et al 2005;Chen et al 2006;Tomono et al 2009). Neoagarobiose (3-O-(3,6-anhydro-Lgalactopyranosyl)-D-galactose), the dimeric form of L-AHG and galactose, can be used as a novel moisturizer with whitening effect (Kobayashi et al 1997).…”

The modern creation technologies of implanted bioartificial liver

“…Снабжение кислородом является лимитирующим фактором при культивировании активно метаболизирующих клеток, таких как гепатоциты [9][10][11]. Nahmias и соавт.…”

Monitoring and preparation of neoagaro- and agaro-oligosaccharide products by high performance anion exchange chromatography systems

“…The marked agarobiose represents the basic unit of the AOS released by HCl action. against apoptosis induced by ROS in a human liver cell L-02 system (Chen, Yan, Zhu, & Lin, 2006). The AOS with DPs 2-8 (A2-A8) oral administration inhibited 2,4,6-trinitrobenzene sulfonic acidinduced colitis in mice through heme oxygenase-1 induction in macrophages, therefore the A2-A8 might be an important therapeutic agents for inflammatory bowel disease (Higashimura et al, 2013).…”