Antioxidant activity and free radical scavenging reactions of hydroxybenzyl alcohols. Biochemical and pulse radiolysis studies

Dhiman, Surajdevprakash B.; Kamat, J.P.; Naik, D.B.

doi:10.1016/j.cbi.2009.07.025

Cited by 33 publications

(23 citation statements)

References 26 publications

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“…However, clinical experiment with synthetic antioxidants has been disappointing. Recently, there is a great interest in many phytochemicals containing phenolic group found in many herbal medicinal plants due to their antioxidant activities [19,23].…”

Section: Discussionmentioning

confidence: 99%

“…4-HBA was found to be more effective than well-known potent antioxidant melatonin in reducing hydrogen peroxide or ferrous ion-induced lipid peroxidation [13]. 4-HBA may act as a free radical scavenger [19]. Kim et al [14] reported that 4-HBA inhibits oxidative stress and excitotoxicity for at least 12 h and suppresses neuronal death in CA1 region.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the antioxidant effect of 4-HBA are of considerable interest. 4-HBA may act as a free radical scavenger [19]. In the present study, we intend to find potential neuroprotecive effect of 4-HBA in focal cerebral ischemia model induced by middle cerebral artery occlusion (MCAO), and its possible role on induction of endogenous antioxidant enzyme.…”

Section: Introductionmentioning

confidence: 96%

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4-Hydroxybenzyl Alcohol Ameliorates Cerebral Injury in Rats by Antioxidant Action

Zhao

Lei

et al. 2010

Neurochem Res

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4-hydroxybenzyl alcohol (4-HBA), one of the phenolic constituents found in many herbal medicinal plants, exhibits beneficial effects in neurological disorders. In the present study, we evaluated 4-HBA's role in transient cerebral ischemia and its potential mechanism. Pre-treatment with 4-HBA (50,100 mg/kg) significantly reduced the cerebral infarct size and improved the neurological symptoms. Morphological examinations showed 4-HBA reduced the number of degenerated neurons. Oxidative stress was evaluated superoxide dismutase (SOD) activity and malondialdehyde (MDA) level. Anti-oxidative mechanisms were studied by Immunofluorescence staining and western immunoblot analysis. 4-HBA increased the expression of NAD(P)H: quinone oxidoreductase1 (NQO1) and ultimately inhibited oxidative stress. In addition, we evaluated the time course expression of NQO1, which was upregulated in the ischemic brain beginning at 1 h. Taken together, these results suggested that 4-HBA ameliorated cerebral injury in rats, This neuroprotective effect is likely related to its antioxidant activities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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4-Hydroxybenzyl Alcohol Ameliorates Cerebral Injury in Rats by Antioxidant Action

Zhao

Lei

et al. 2010

Neurochem Res

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“…HBA has received attention as a neuroprotective agent due to its anti-oxidative, anti-excitotoxic, and anti-apoptosis abilities (Liu & Mori 1992;Dhiman et al 2009;Yu et al 2010;Yu et al 2011). The effect of HBA on functional recovery may be related to the increased expression of neurotrophic factor genes (Yu et al 2005;Kam et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Combination effect ofp-hydroxybenzyl alcohol and mesenchymal stem cells on the recovery of brain damage in a rat model of brain ischemia

Kaengkan

Baek

Choi

et al. 2013

Animal Cells and Systems

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(2013) Combination effect of p-hydroxybenzyl alcohol and mesenchymal stem cells on the recovery of brain damage in a rat model of brain ischemia, Animal Cells and Systems, 17:3, 160-169, DOI: 10.1080/19768354.2013 p-Hydroxybenzyl alcohol (HBA), an active component of Gastrodia elata blume, has been reported to provide neuroprotection by preventing brain damage. Transplantation of mesenchymal stem cell (MSC) has been shown to ameliorate ischemic brain injury in animals. To explore a way that might enhance neuroprotection after brain stroke, we investigated whether the transplantation of neural progenitor cells (NPCs) derived from MSCs from adipose tissue combined with HBA may enhance neuroprotective effects in an animal model of brain stroke. Intracarotid injection of combination therapy groups showed a significant reduction of infarct volume by 2,3,5-triphenyltetrazolium chloride staining and an improvement of neurological functions were observed at 3 days after middle cerebral artery occlusion (MCAO), compared to monotherapy groups. In our studies, immunohistochemistry showed that NPCs are more likely to enter a damaged brain than a contralateral nonischemic brain. Coadministration of HBA and NPCs enhanced the anti-apoptotic effect and reduced the number of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling-positive apoptotic cells compared to the vehicle and NPCs at 7 days after MCAO. HBA and the combination of HBA 'NPCs induced the expression of genes encoding antioxidant proteins, including PDI, Nrf2, endogenous neurotrophic factor gene brain-derived neurotrophic factor, NGF, and VEGF, which enhances angiogenesis in an ischemic brain. These effects might be responsible for the survival of NPCs and improved functional behavior. Our finding indicates that combination therapy of HBA and NPCs enhances neuroprotection against ischemic brain injury.

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“…Generally speaking, the reaction centre of the investigated antioxidant should be easily accessible, a free radical should be a small or medium sized to avoid potential steric hindrance. The RAF is the most likely mechanism for the free radical scavenging of hydroxyl radical with: gentisic acid (Joshi et al 2012) caffeine (León-Carmona et al 2011), melatonin , and its metabolites Galano et al 2014), hydroxybenzyl alcohols (Dhiman et al 2009) and carnosine (Tamb et al 1999). …”

Section: And [а-оH-r]mentioning

confidence: 99%

Study of the mechanisms of antioxidative action of different antioxidants

Marković¹

2016

J Serb Soc Comp Mech

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The reaction mechanisms by which antioxidants can exert their activity are: hydrogen atom transfer (HAT), proton coupled electron transfer (PCET), sequential proton loss electron transfer (SPLET), single electron transfer -proton transfer (SET-PT), radical adduct formation, and sequential proton loss hydrogen atom transfer. The antioxidative activity of different compounds (flavones, flavonols, and Schiff basis) was investigated by the trolox equivalent antioxidative capacity and electron paramagnetic resonance methods. The mechanisms of the antioxidative action (HAT, PCET, SPLET, and SET-PT) were investigated by using the thermodynamic parameters: bond dissociation enthalpy, ionization potential, proton dissociation enthalpy, proton affinity, and electron-transfer enthalpy. The influence of different radicals was investigated using appropriate isodesmic reactions. The mechanistic approach to the investigation of the influence of different radicals to the HAT mechanism, and the second step of the SET-PT mechanism) was applied. These investigations contribute to the elucidation and understanding of complex processes involved in the antioxidative action.

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Antioxidant activity and free radical scavenging reactions of hydroxybenzyl alcohols. Biochemical and pulse radiolysis studies

Cited by 33 publications

References 26 publications

4-Hydroxybenzyl Alcohol Ameliorates Cerebral Injury in Rats by Antioxidant Action

4-Hydroxybenzyl Alcohol Ameliorates Cerebral Injury in Rats by Antioxidant Action

Combination effect ofp-hydroxybenzyl alcohol and mesenchymal stem cells on the recovery of brain damage in a rat model of brain ischemia

Study of the mechanisms of antioxidative action of different antioxidants

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