Antioxidant Activity and a New Ursane-type Triterpene from Vitellaria paradoxa (Sapotaceae) Stem Barks

Talla, Emmanuel; Nyemb, Jean Noël; Tiabou, Alembert Tchinda; Djou, Sandrine; Biyanzi, Pierre; Laurent, Sophie; Elst, Luce Vander; Tanyi, Joseph Mbafor

doi:10.9734/ejmp/2016/28847

Cited by 15 publications

(7 citation statements)

References 35 publications

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“…Quantitative analysis revealed that the dichloromethane leaf extract contained 21.18 ± 0.50% of UA and 6.21 ± 0.12% of OA, vs. 2.06 ± 0.18% and 0.18 ± 0.04% respectively, in the twigs. While many other triterpenic acids have been identified in low amounts in Vitellaria paradoxa [ 11 , 12 ], this work is the first to report ursolic and oleanolic acids as the most abundant triterpenic acids in the leaves of Vitellaria paradoxa.…”

Section: Resultsmentioning

confidence: 81%

Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms

et al. 2017

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Combining antibiotics with resistance reversing agents is a key strategy to overcome bacterial resistance. Upon screening antimicrobial activities of plants used in traditional medicine, we found that a leaf dichloromethane extract from the shea butter tree (Vitellaria paradoxa) had antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) with further evidence of synergy when combined with β-lactams. Using HPLC-MS, we identified ursolic (UA) and oleanolic acids (OA) in leaves and twigs of this species, and quantified them by HPLC-UV as the major constituents in leaf extracts (21% and 6% respectively). Both pure triterpenic acids showed antimicrobial activity against reference and clinical strains of MRSA, with MICs ranging from 8–16 mg/L for UA to 32–128 mg/L for OA. They were highly synergistic with β-lactams (ampicillin and oxacillin) at subMIC concentrations. Reversion of MRSA phenotype was attributed to their capacity to delocalize PBP2 from the septal division site, as observed by fluorescence microscopy, and to disturb thereby peptidoglycan synthesis. Moreover, both compounds also inhibited β-lactamases activity of living bacteria (as assessed by inhibition of nitrocefin hydrolysis), but not in bacterial lysates, suggesting an indirect mechanism for this inhibition. In a murine model of subcutaneous MRSA infection, local administration of UA was synergistic with nafcillin to reduce lesion size and inflammatory cytokine (IL-1β) production. Thus, these data highlight the potential interest of triterpenic acids as resistance reversing agents in combination with β-lactams against MRSA.

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Section: Resultsmentioning

confidence: 81%

Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms

et al. 2017

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“…Secondary metabolites are present in the shea tree's plant parts (leaves, bark, stems, roots, and fruits) [133]. The phytochemical analysis of leaves and bark extract of shea tree have revealed compounds, such as alkaloids, flavonoids, tannins, steroids, phenols, phlobatannins, glycosides, and carbohydrates [76,116,[134][135][136].…”

Section: Biochemical and Phytochemical Composition Of Shea Kernels An...mentioning

confidence: 99%

The Current State of Knowledge of Shea Butter Tree (Vitellaria paradoxa C.F.Gaertner.) for Nutritional Value and Tree Improvement in West and Central Africa

Nguekeng

Hendre

Tchoundjeu³

et al. 2021

Forests

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Vitellaria paradoxa (C.F.Gaertn.) is a multi-purpose tree species distributed in a narrow band across sub-Saharan Africa. The species is integrated into cropping and agroforestry systems as a nutritional and economic resource, which provides a range of environmental services. Integration of the species into land-use systems provides an essential source of livelihoods and income for local populations. The economic potential of the shea butter tree derives from its edible products, which also serve cosmetic and pharmaceutical applications. To understand the current state of knowledge about V. paradoxa, this paper summarizes information about the ecology, population structure, and genetic diversity of the species, also considering compositional variation in the pulp and kernels, management practices, and efforts towards its domestication. Despite the great potential of the shea butter tree, there are some gaps in the understanding of the genetics of the species. This review presents up-to-date information related to the species for further domestication and breeding purposes.

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“…Vitamin C was used as reference. Percentage of DPPH free radical scavenging activity was calculated by the following equation [16]:…”

Section: Determination Of the In Vitro Antioxidants Activitiesmentioning

confidence: 99%

Mnemonic and neuroprotective properties of Sclerocarya birrea root bark decoction on mouse model of monosodium glutamate-induced neurotoxicity involve by its antioxidant activities

Nonmarmbaye¹,

Kouemou²,

Sidiki³

et al. 2021

GSC Biol. and Pharm. Sci.

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Ethnopharmacological relevance: Sclerocarya birrea (A. Rich.) Hochst. (Anacardiaceae) is a medicinal plant known for the treatment of several diseases such as epilepsy, hypertension, inflammation and memory disorders in Cameroonian folk medicine. Aim of the study: The aim of this work is to evaluate the memory improvement and neuroprotective effects of Sclerocarya birrea aqueous root bark extracts and investigate it antioxidant properties. Materials and methods: T-maze and the object recognition test in an open field were used for behavioral testing to detect its neuroprotective and memory improvement properties. The DPPH test was used to predict antioxidant activities in vitro. The in vivo antioxidant activities of the aqueous extracts were investigated using the Monosodium glutamate induced oxidative stress and neurotoxicity mouse model. After the behavioral testing, animals were decapitated and the brains were removed for oxidative stress biomarkers determination. Results: Sclerocarya birrea decreased the preferred arm choice latency and the time spent in the discriminated, in the T-maze. It increased exploration time and recognition index, and decreased the latency to explore the new object B. In addition, Sclerocarya birrea increased the superoxide dismutase and catalase activities, and reduced glutathione level. Conclusion: These results suggest that Sclerocarya birrea possess neuroprotective and mnemonic activities in mice that might involve by its free radicals scavenging properties

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Antioxidant Activity and a New Ursane-type Triterpene from Vitellaria paradoxa (Sapotaceae) Stem Barks

Cited by 15 publications

References 35 publications

Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms

Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms

The Current State of Knowledge of Shea Butter Tree (Vitellaria paradoxa C.F.Gaertner.) for Nutritional Value and Tree Improvement in West and Central Africa

Mnemonic and neuroprotective properties of Sclerocarya birrea root bark decoction on mouse model of monosodium glutamate-induced neurotoxicity involve by its antioxidant activities

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