Antioxidant Activities of Vaccinium vitis-idaea L. Leaves within Cultivars and Their Phenolic Compounds

Raudonė, Lina; Vilkickytė, Gabrielė; Pitkauskaitė, Lina; Raudonis, Raimondas; Vainorienė, Rimanta; Motiekaitytė, Vida

doi:10.3390/molecules24050844

Cited by 51 publications

(42 citation statements)

References 48 publications

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“…Neuroprotective effect of the extracts was evidenced in vitro by Vyas et al using acetone as the solvent [37]. Recent studies highlight that leaf extracts possess great reducing, radical scavenging and chelating activities and could be considered as a promising source of bioactive compounds with notable antioxidant activity [39].…”

Section: Phenolic Compounds Present In Vaccinium Species Leavesmentioning

confidence: 99%

Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits

et al. 2019

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Some species of the Ericaceae family have been intensively studied because of the beneficial health impact, known since ancient times, of their chemical components. Since most studies focus on the effects of fruit consumption, this review aims to highlight the phenolic components present in the leaves. For this purpose, five species from Ericaceae family (bilberry—Vaccinium myrtillus L., lingonberry—V. vitis-idaea L., bog bilberry—V. uliginosum L., blueberry—V. corymbosum L. and bearberry—Arctostapylos uva-ursi L.) were considered, four of which can be found in spontaneous flora. The chemical composition of the leaves revealed three major phenolic compounds: chlorogenic acid, quercetin and arbutin. The health promoting functions of these compounds, such as antioxidant and anti-inflammatory properties that could have preventive effects for cardiovascular disease, neurodegenerative disorders, cancer, and obesity, have been exemplified by both in vitro and in vivo studies in this review. Furthermore, the importance of bioaccessibility and bioavailability of the phenolic compounds have been summarized. The findings highlight the fact that leaves of some Ericaceae species deserve increased attention and should be studied more profoundly for their biological activities, especially those from spontaneous flora.

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Section: Phenolic Compounds Present In Vaccinium Species Leavesmentioning

confidence: 99%

Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits

et al. 2019

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“…The antioxidant capacity determined by the ABTS, FRAP, and FIC (ferrous ions chelating) methods of different cultivars and lower taxa of lingonberry leaves extracts were compared, and showed that "Kostromskaja rozovaja" and "Rubin" cultivars, as well as V. vitis-idaea var. leucocarpum, possessed the greatest reducing, radical scavenging, and chelating activities [61].…”

Section: Antioxidant Activity Of Phenolic Compounds and Vaccinium Extmentioning

confidence: 99%

Phenolic Antioxidants in Aerial Parts of Wild Vaccinium Species: Towards Pharmaceutical and Biological Properties

2019

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Phenolic compounds are a widespread group of secondary metabolites found in all plants, representing the most desirable antioxidants due to their potential to be used as additives in the food industry (inhibition of lipid oxidation), and in cosmetology and medicine (protection against oxidative stress). In recent years, demand for the identification of edible sources rich in phenolic antioxidants, as well as the development of new natural plant products to be used as dietary supplements or pharmaceuticals, has been a great preoccupation. At present, from the “circular economy” perspective, there is an increased interest to use agricultural waste resources to produce high-value compounds. Vaccinium leaves and stems are considered essentially an agro-waste of the berry industry. Scientific studies have shown that phenolic compounds were found in a markedly higher content in the leaves and stems of Vaccinium plants than in the fruits, in agreement with the strongest biological and antioxidant activities displayed by these aerial parts compared to fruits. This paper aims to review the current state of the art regarding the phenolic antioxidants from leaves and stems of two wild Vaccinium species, bilberry (Vaccinium myrtillus L.) and lingonberry (Vaccinium vitis-idaea L.), as promising natural resources with pharmaceutical and biological activity.

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“…flavonols, cinchonains, iridoids, and arbutin derivatives [ 14 , 23 , 27 ]. Extracts of lingonberry leaves have shown multiple beneficial diuretics and antiseptic properties for the urinary tract, anti-cough, phlegm removing, anti-inflammatory, neuroprotective, and antioxidant activity [ 21 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Biological Activities of the Nord-West Romanian Wild Bilberry (Vaccinium myrtillus L.) and Lingonberry (Vaccinium vitis-idaea L.) Leaves

et al. 2020

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This study was performed to evaluate and compare the in vitro antioxidant, antimicrobial, and antimutagenic activities, and the polyphenolic content of the Nord-West Romanian wild bilberry (Vaccinium myrtillus L.) and lingonberry (Vaccinium vitis-idaea L.) leaves from three different natural habitats (Smida, Turda, Borsa). In the case of both species, the flavanols level was higher in Smida habitat (altitude 1100 m), whereas quercetin derivates were more abundant in Borsa habitat (altitude 850 m). The bilberry leaf extracts contained in the highest amounts the feruloylquinic acid (59.65 ± 0.44 mg/g for Borsa habitat) and rutin (49.83 ± 0.63 mg/g for Borsa habitat), and showed relevant 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant activity (271.65 mM Trolox/100 g plant material for Borsa habitat, 262.77 mM Trolox/100 g plant material for Smida habitat, and 320.83 mM Trolox/100 g plant material for Turda habitat), for all the three extracts. Gallocatechin was the dominant flavanol in lingonberry species, with the highest amount being registered for Smida habitat (46.81 ± 0.3 mg/g), revealing a DPPH antioxidant activity of 251.49 mM Trolox/100 g plant material. The results obtained in the antimicrobial tests showed that the best inhibitory effect among bilberry species was attributed to the Turda (altitude 436 m) and Smida locations, against both Gram-positive and Gram-negative bacterial strains. For lingonberry, the differences in habitat did not influence the antibacterial effect, but the antifungal effect, only in the case of Candida zeylanoides. A strong antimutagenic effect was registered by the bilberry leaves toward Salmonella typhimurium TA100. Our study may be able to provide a better understanding of the correlation between natural habitat conditions and the accumulation of secondary metabolites and their related bioactivities in studied leaves.

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Antioxidant Activities of Vaccinium vitis-idaea L. Leaves within Cultivars and Their Phenolic Compounds

Cited by 51 publications

References 48 publications

Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits

Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits

Phenolic Antioxidants in Aerial Parts of Wild Vaccinium Species: Towards Pharmaceutical and Biological Properties

Chemical Composition and Biological Activities of the Nord-West Romanian Wild Bilberry (Vaccinium myrtillus L.) and Lingonberry (Vaccinium vitis-idaea L.) Leaves

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