Antioxidant activities of tocopherols

Ohkatsu, Yasukazu; Kajiyama, Tetsuto; Arai, Yuji

doi:10.1016/s0141-3910(01)00022-2

Cited by 41 publications

(21 citation statements)

References 13 publications

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“…As a result, the kinh value will be increased in the presence of an amine, especially, an amine with a low ionization potential. This result supports the antioxidant mechanism for tocopherol proposed previously 8) .…”

Section: Resultssupporting

confidence: 92%

Promoters for Tocopherols as Antioxidants

Matsuzaki

Takahashi

Ohkatsu

2004

J. Jpn. Petrol. Inst.

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Many kinds of additives are used to prevent the degradation of organic chemicals, including macromolecular materials. Tocopherols are natural products known to be effective antioxidants. Now, on the basis of the antioxidation mechanism of tocopherols proposed by us, we have studied amines as promoters, which may enhance the antioxidant activity of a tocopherol, and studied 4-n-butoxyphenol, too, as model compounds as tocopherols. It was found that amines exhibit an antagonism to 4-alkylphenols, such as 2,6-di-t-butyl-4-methylphenol, whereas they exhibit certain synergism to 4-alkoxyphenols. In addition, it is clarified that an amine having a low ionization potential improves the antioxidant activity of α-tocopherol.

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Section: Resultssupporting

confidence: 92%

Promoters for Tocopherols as Antioxidants

Matsuzaki

Takahashi

Ohkatsu

2004

J. Jpn. Petrol. Inst.

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“…(Rezzani et al, 2005). WGO was found to contain the highest content of the most powerful natural antioxidant vitamin E than any other natural source (Ohkatsu et al, 2001;Shurpalekar & Rao, 1977;Wolf et al, 1998). Thus, it was interesting to investigate the potential protective role of WGO on CsA-induced hepatotoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…ROS induced by CsA can be antagonized by using a powerful antioxidant agent (Kaya et al, 2008;Rezzani, 2006). Wheat germ oil (WGO) is an excellent source of natural vitamin E, the most powerful natural antioxidant (Ohkatsu et al, 2001;Shurpalekar & Rao, 1977;Wolf et al, 1998). WGO is also rich in unsaturated fatty acids, mainly oleic, linoleic, and a-linolenic acids that may inhibit oxidative stress (Alessandri et al, 2006;Sjovall et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Molecular mechanisms of the protective role of wheat germ oil against cyclosporin A-induced hepatotoxicity in rats

Akool

2015

Pharmaceutical Biology

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Context: Cyclosporin A (CsA) is one of the most important immunosuppressive agents. However, its clinical use is strongly limited by several side effects including hepatotoxicity which remains a major clinical problem. Involvement of reactive oxygen species (ROS) in CsAinduced hepatotoxicity has been reported. Objective: This study investigates the potential protective role of wheat germ oil (WGO) as an antioxidant against CsA-induced hepatotoxicity. Materials and methods: Twenty-four male Wistar albino rats (six animals in each group) received castor oil, the vehicle of CsA i.p. (control) or either CsA (25 mg/kg/d i.p.), WGO (900 mg/kg/d by oral gavage), or CsA in combination with WGO daily for 21 d. Results: CsA administration significantly increased serum levels of the liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In addition, an increase in lipid peroxidation, inducible NO-synthase (iNOS), and NF-kB expression were observed in hepatic tissues of CsA-alone-treated rats. Furthermore, significant reduction in the hepatic content of reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) was also observed in CsA-alone-treated animals. Moreover, histopathological changes occurred in CsA-alonetreated rats. Concomitant administration of WGO along with CsA improved all these parameters. Most interestingly, the immunosuppressive effect of CsA was not affected by WGO. Conclusion: The present study suggests that concomitant use of WGO might be useful in reducing liver toxicity induced by CsA via inhibition of ROS, iNOS, and NF-kB expression.

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“…The antioxidant activity of tocopherols is well documented (Ohkatsu et al, 2001). One physiological role of vitamin E is its ability to react with and quench free radicals in cell membranes and other lipid environments, thereby preventing polyunsaturated fatty acids (PUFA) from oxidation.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of a wheat germ rich diet against the toxic influence of profenofos on rat tissue lipids and oxidative pentose phosphate shunt enzymes

Abdel-Rahim¹,

Mahmoud²

2011

Grasas y Aceites

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The effects of technical and formulated forms of profenofos on the metabolic lipid fractions of the liver, brain and kidneys as well as the activity of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD), which consider lipid related enzymes, were studied. The two forms of profenofos were given separately either orally or by dermal at doses of 1/20 LD50 for 3 months (one dose every 48 h). Total lipids and lipid fractions (cholesterol, triglycerides and phospholipid contents) decreased in the three studied organ tissues either in technical or formulated profenofos-induced rats compared with normal control animals. The highest effect was observed in the case of orally formulated profenofo induction, and the lowest was detected for the dermal technical one. The same trend was found in the activities of G6PD and 6PGD associated with lipid metabolism in the liver, brain and kidney tissues under the same conditions. On other hand, the treatment of profenofos-induced animals by feeding a wheat germ rich diet (as antioxidant agent) produced significant improvements in both lipid fraction content and enzyme activity. In addition, the effects of the wheat germ rich diet (α-tocopherol rich source) readjusted and improved the disturbed metabolic fractions of the lipid profiles in the profenofos-induced rats as well as their related enzyme activities (G6PD and 6PGD: oxidative pentose phosphate shunt). El efecto de formas técnicas o formuladas de profenofós en la fracción lipídica metabólica de hígado, cerebro y riñones así como la actividad de la glucosa-6-fosfato deshidrogenasa (G6PD) y 6-fosfogluconato deshidrogenasa (6PGD), que son consideradas enzimas relacionadas con los lípidos, fueron estudiadas. Ambas formas de profenofós fueron suministradas separadamente tanto por vía oral como cutánea a una dosis de 1/20 LD50 durante 3 meses (una dosis cada 48 horas). Los lípidos totales y fracciones lipídicas (contenido de colesterol, triglicéridos y fosfolípidos) decrecieron en los tres órganos estudiados de ratas tratadas con profenofós tanto técnicos como formulado comparado con animales control. El mayor efecto fue observado en el caso de tratamientos orales con profenofós formulados, mientras que el más bajo fue detectado para el tratamiento cutáneo con profenofós técnicos. La misma tendencia fue encontrada en las actividades de G6PD y 6PGD asociadas con el metabolismo lipídico de tejidos de hígado, cerebro y riñón bajo las mismas condiciones. Por otra parte, animales tratados con profenofós y alimentados con una dieta rica en germen de trigo (como agente antioxidante) produjo una significativa mejora tanto en el contenido de las fracciones lipídicas como en la actividad enzimática. Es más, el efecto de dietas ricas en germen de trigo (fuente rica de α-tocoferol) reajustó y mejoró el trastorno metabólico del perfil lipídico de las fracciones en ratas tratadas con profenofós, así como su actividad enzimática relacionada (G6PD y 6P...

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Antioxidant activities of tocopherols

Cited by 41 publications

References 13 publications

Promoters for Tocopherols as Antioxidants

Promoters for Tocopherols as Antioxidants

Molecular mechanisms of the protective role of wheat germ oil against cyclosporin A-induced hepatotoxicity in rats

Protective effects of a wheat germ rich diet against the toxic influence of profenofos on rat tissue lipids and oxidative pentose phosphate shunt enzymes

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