Antioxidant Activities of Synthetic Indole Derivatives and Possible Activity Mechanisms

Süzen, Síbel

doi:10.1007/7081_2007_074

Cited by 136 publications

(55 citation statements)

References 151 publications

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“…The balance between free radicals and the antioxidant system of the body has a vital importance in maintaining the health status of organism [1][2][3] . Reactive oxygen species (ROS) and reactive nitrogen species are well known as both harmful and beneficial species.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues

Püsküllü

Shirinzadeh

Nenni

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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Overproduction of reactive oxygen species results in oxidative stress that can cause fatal damage to vital cell structures. It is known that the use of antioxidants could be beneficial in the prevention or delay of numerous diseases associated with oxidative stress. Melatonin (MLT) is known as a powerful free-radical scavenger and antioxidant. It was found that indole ring of MLT can be employed by bioisosteric replacement by other aromatic rings. Quinoline derivatives constitute an important class of compounds for new drug development. Owing to quinoline and hydrazones appealing physiological properties and are mostly found in numerous biologically active compounds a series of quinoline-2-carbaldehyde hydrazone derivatives were synthesized as bioisosteric analogues of MLT, characterized and in vitro antioxidant activity was investigated by evaluating their reducing effect against oxidation of a redox-sensitive fluorescent probe. Cytotoxicity potential of all compounds was investigated both by lactate dehydrogenase leakage assay and by MTT assay.

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Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues

Püsküllü

Shirinzadeh

Nenni

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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show abstract

“…Due to its good water solubility, this antioxidant has been broadly used as a standard when screening antioxidant efficacy of other prospectively active compounds in studies involving chemical, subcellular, cellular and tissue models of oxidative stress mediated injury (Aruoma, 2003;Huang et al, 2005;Prior et al, 2005). On the other hand, a fairly large and specific group of substances with beneficial antioxidant effects is derived from indole structure (Suzen, 2007). This puts a demand on the reassessment of the suitability of a phenol-type reference trolox, particularly in studies on screening of nitrogen heterocyclic antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Stobadine – An Indole Type Alternative to the Phenolic Antioxidant Reference Trolox

Juránek¹,

Račková²,

Štefek³

2012

Biochemistry

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“…Indole moiety occurs widely in synthetic and natural products containing an important class of therapeutic agents 10,11 . In the last decade, antioxidant activity of synthetic indole derivatives and their possible activity mechanisms have been widely studied 11 .…”

Section: Introductionmentioning

confidence: 99%

“…In the last decade, antioxidant activity of synthetic indole derivatives and their possible activity mechanisms have been widely studied 11 . Generally, pharmacophores containing typically the phenol moiety possess good antioxidant activity 12 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and In Vitro Antioxidant Evaluation of Some Indole-2-carboxylic Acid-Aryl Amine Conjugates

Naik¹,

Sharath²,

Kumar³

et al. 2012

Chem Sci Trans

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A simple and efficient protocol for the synthesis of novel indole-2-carboxylic acid analogues having aryl amine moieties (2a-k) has been described. The synthesized compounds were characterized by spectroscopic techniques (IR, 1 H NMR, 13 C NMR and MS-EI) and further screened for their antioxidant activity by using various in vitro assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH • ) scavenging assay, 2,2 ' -azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS •+ ) radical scavenging activity, ferric reducing antioxidant power, cupric ion reducing ability method and phosphomolybdate method. In all the antioxidant assays performed, compounds 2b, 2d, 2e and 2f showed promising antioxidant activity. Whereas, compound 2c displayed potent antioxidant activity.

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Antioxidant Activities of Synthetic Indole Derivatives and Possible Activity Mechanisms

Cited by 136 publications

References 151 publications

Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues

Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues

Stobadine – An Indole Type Alternative to the Phenolic Antioxidant Reference Trolox

Synthesis and In Vitro Antioxidant Evaluation of Some Indole-2-carboxylic Acid-Aryl Amine Conjugates

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