Antioxidant activities of leaf galls extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae)

Abstract

Background. Free radicals are implicated in several metabolic diseases and the antioxidant therapy has gained an utmost importance in the treatment. The medicinal properties of plants have been investigated and explored for their potent antioxidant activities to counteract metabolic disorders. In this study, the chemical composition and free radical scavenging potential of leaf gall extracts (ethanol, petroleum ether, chloroform and aqueous) of Terminelia chebula is evaluated, which is extensively used in the preparation of traditional medications to treat various metabolic diseases. Material and methods. The presences of phenolics, fl avonoids, triterpens, saponins, glycosides, phytosterols, reducing sugars were identifi ed in the extracts according to standard procedures. The free radical scavenging activities of the extract were also analysed by standard procedures. Results. The methanol extract had the highest total phenolic and fl avonoid content. The antioxidant activities of leaf gall extracts were examined using diphenylpicrylhydrazyl (DPPH), Super oxide radical scavenging, Hydroxyl scavenging and ferric reducing power (FRAP) methods. In all the methods, the ethanolic extract showed higher free radical scavenging potential than all the other extracts. Conclusion. As the higher content of both total phenolics and fl avonoids were found in the ethanolic extract, so the signifi cantly high antioxidant activity can be positively correlated to the high content of total polyphenols/fl avonoids of the ethanol extract. The results of this study confi rm the folklore use of T. chebula leaves gall extracts as a natural antioxidant and justify its ethnobotanical use. Further, the results of antioxidant properties encourage the use of T. chebula leave gall extracts for medicinal health, functional food and nutraceutical applications.

Antioxidant and Antitumorigenic Activities of the Standardized Water Extract From Fruit of Terminalia chebula Retz. var. chebula

“…66 In addition, Birur Eshwarappa et al (2015) showed that leaf gall extracts of T chebula exhibited DPPH scavenging activity with IC 50 values of 274 ± 2, 201 ± 3, 143 ± 6, and 96 ± 2 μg/mL when extracted with light petroleum, chloroform, aqueous, and ethanol solvents, respectively. 67 Chen et al (2011) reported that triethylchebulate, an aglycone isolated from T chebula, had a strong free-radical scavenger effect with an IC 50 value of 2.4 × 10 −5 M 68 , while Lee et al (2005) reported that the aqueous extract of the fruit of T chebula scavenged radical DPPH with an EC 50 of 127.1 ± 1.8 μg (dry matter)/mL. 69 Suksaeree et al 12 investigated the synergistic antioxidant activity of T chebula , T arjuna , T bellirica , and Phyllanthus emblica using response surface analysis.…”

A survey on the anti-Trichomonas vaginalis effect of the hydroalcoholic extract of various medicinal plants in vitro

“…Important compounds of T. chebula Retz are chebulic, chebulinic, gallic, corilagin, and ellagic acids. This plant has antibacterial and antifungal, anti-amoebic, anti-malarial, antiviral, and antioxidant activities (24). A limited number of studies have reported the mechanism actions of these plants against T. vaginalis.…”

Phytotherapeutic Approaches to the Prevention of Age-Related Changes and the Extension of Active Longevity

“…Plant seed extracts have been demonstrated to exhibit neuroprotective effects in experimental studies. Chebulic acid has pronounced neuroprotective properties [ 142 ]. Ellagic acid from Chebulic myrobalans has the same properties [ 143 ].…”