Antioxidant activities of lead (Leucaena leucocephala) seed as affected by extraction solvent, prior dechlorophyllisation and drying methods

Benjakul, Soottawat; Kittiphattanabawon, Phanat; Sumpavapol, Punnanee; Maqsood, Sajid

doi:10.1007/s13197-012-0846-1

Cited by 45 publications

(88 citation statements)

References 47 publications

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“…The result was confirmed by FRAP method showing the reducing power activity of dried extract at 428.54 ±15.32 mM FeII equivalent/g. This result showed higher scavenging activity comparing to previous study 16 that observing the activity in seed extract 17,18 , suggested leave extract might provide greater scavenging activity compared with the seed part. The effects of L. leucocephala on HUVCs metabolites were shown in Figure 1 to 4, despite on each category.…”

Section: Conclusion and Discussioncontrasting

confidence: 53%

“…Total phenolic and flavonoid contents was determined, and the result showed 51.04 ± 0.91 mgGAE/g and 0.13 ± 0.01 mg of catechin/g content in dry leave extract, respectively. Likewise, other studies that found phenolic at 3.21 mg GAE/g, 33 37.38 ± 0.49 mg GAE/g, 17 78.8 g GAE/100g extract, 18 258.4±7.45 mg GAE/g, 16 7.51 to 12.06 mg GAE/g, 34 and flavonoid contents at 159.61±12.79 mg QE/g (Quercetin equivalent), 16 2.80 to 3.59 mg QE/g 34 depended on parts of plant collection and solution extracted. This compon ents suggest antioxidant activities of L. leucocephala, as confirmed in Table 1.…”

Section: Conclusion and Discussionmentioning

confidence: 52%

“…15 It has been reported for lowering blood glucose, blood pressure and NO level, and providing hypochlolesteromic, anti-inflammatory and antioxidant activity. 16,17,18 In previous studies, glucose and LDL can induce endothelial dysfunction of the vessels in diabetic and cardiovascular patients. 9,19,20 Thus, optimal level of L. leucocephala may protect vascular cell through reduction of LDL and glucose centrifugation method, described previously.…”

Section: Introductionmentioning

confidence: 95%

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Effects of Leucaena leucocephala (Lam.) de Wit Leaves Extracts in Culture of Human Umbilical Vein Cells

Chatchanayuenyong¹,

Sujayanont²,

Vuttivirojana³

2017

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Oxidative stress can induce vascular endothelial dysfunction in diabetic and hyperlipidemia patients. Leucaena leucocephala (Lam.) de Wit has been reported of possessing antioxidant, antidiabetic and anticholiesterase activity; as well as the toxic substance called mimosine. Aims: To determine antioxidant effects of Leucaena leucocephala (Lam.) de Wit Leave extracts in oxidative stress induced vascular endothelial function. Methods and Material: Leave extracts were determined for antioxidant activity. Either or both of oxidized low density lipoprotein (oxLDL) and glucose were applied to induce oxidative stress condition in human umbilical vein cultured (HUVCs) to observe superoxide dismutase (SOD) activity, nitric oxide (NO) level and morphological changes. Results: Total polyphenol and flavonoid were 51.04 ± 0.91 mg GAE/g and 0.13 ± 0.01 mg catechin/g of dried weight (DW), respectively. Free radical reduction efficiency of crude extract observed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay showed IC 50 value of 329.6 µg of vitamin C equivalent/mg of extracts. Frap value was showed 428.54 ± 15.32 mM FeII equivalent/g of DW. The result observing in HUVCs showed that comparing to the control, SOD activity, NO and MDA level were maintained in 0.05 mg/mL of L. leucocephala treated group, but NO and MDA level were lowered when comparing with oxLDL and glucose-induced oxidative stress. No change was observed in 0.05 mg/mL of L. leucocephala treated group, comparing with control group. Conclusion: This study has been performed to exhibit the antioxidant activity of L. leucocephala in endothelium functions and has been found to have an appropriate concentration at 0.05 mg/mL in reducing oxidative stress condition in impaired fasting blood glucose patients. Nevertheless, the optimal level for toxic activity in inhibition of cancer angiogenesis should be further investigated.

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Section: Conclusion and Discussioncontrasting

confidence: 53%

Section: Conclusion and Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 95%

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Effects of Leucaena leucocephala (Lam.) de Wit Leaves Extracts in Culture of Human Umbilical Vein Cells

Chatchanayuenyong¹,

Sujayanont²,

Vuttivirojana³

2017

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“…Ethanol was reported to be an effective solvent for chlorophyll extraction (Sartory & Grobbelaar 1984). Benjakul, Kittiphattanabawon, Sumpavapol, and Maqsood (2014) reported that phenolic compounds and mimosine from lead seed could be effectively released when the water was used as the extraction medium, while lower amounts of chlorophyll were extracted. In general, a green colored extract might be an obstacle for further application.…”

Section: Total Chlorophyll Content (Tcc) and Colormentioning

confidence: 99%

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Yarnpakdee¹,

Benjakul²,

Senphan³

2019

Turk. J. Fish. Aquat. Sci.

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Characteristic and antioxidant activity of the extracts from freshwater macroalgae (C. glomerata) as influenced by extraction media, i.e., water or ethanol (20-100%, v/v) were studied. The highest yield (28.0%) was obtained when water was used. Ethanolic extracts had significantly lower yields (2.98-15.5%) (P<0.05). However, total phenolic and chlorophyll contents were lower in water extract. Among all extracts, the 60% ethanolic extract (E60) had the highest antioxidant activities, including DPPH and ABTS radical scavenging activities, ferric reducing antioxidant power and metal chelating activity. Based on LC/MS of E60, quercetin, isoquercetin and hydroquinin were the major phenolic compounds. When E60 at different levels (100, 200 and 400 mg/kg) were added to eastern little tuna (Euthynnus affinis) slices, the reduction in lipid oxidation was dose-dependent (P<0.05) as shown by smaller increases in peroxide and thiobarbituric acid-reactive substances (TBARS) values, compared to the control. Therefore, C. glomerata could be a source of alternative natural antioxidant in lipid based muscle food.

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“…Compared with other plants, the antioxidant property of Leucaena or other Mimosae has been investigated sporadically. Benjakul et al (2014) reported the antioxidant activities in Leucaena seeds and observed that the antioxidative activities were dependent on extracting solvents. The antioxidant activities in Mimosa pudica were also investigated (Genest et al 2008;Parmar et al 2015), but how much mimosine contributed to the antioxidant property in Leucaena and M. pudica has not been studied.…”

Section: Introductionmentioning

confidence: 99%

Isolation and biological activities of 3-hydroxy-4(1H)-pyridone

Xuan

Minh

Khanh

2016

Journal of Plant Interactions

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3-Hydroxy-4(4H)-pyridone (3,4-DHP), a degraded product of mimosine [β-[N-(3-hydroxy-4-oxypyridyl)]-α-aminopropionic acid], is known to cause goiters, loss of hair, and infertility in animals, but limits of 3,4-DHP on separation and purification have prevented efforts on investigating other toxicity and biological properties of 3,4-DHP. By this study, a novel and simple isolation of 3,4-DHP was developed either from Leucaena leaves using an ion-exchanged resin or mimosine degraded in high temperature (110°C, 6 h). The inhibition of mimosine on the growth of barnyardgrass was approximately fourfold higher (IC 50 = 0.04 mg g −1 ) than that of 3,4-DHP (IC 50 = 0.15 mg g −1 ). In general, the antifungal activity of mimosine is much stronger than that of 3,4-DHP, but it differs depending on the kind of fungi. The 1,1-diphyenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of 3,4-DHP, in contrast with the growth inhibitory activity, is about fourfold stronger [EC 50 = 2.4 mg g −1 gallic acid equivalent (GAE)] than that of mimosine [EC 50 = 10.3 mg g −1 GAE]. This study is the first to report on the herbicidal, antifungal, and antioxidant activities of 3,4-DHP. ARTICLE HISTORY

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Antioxidant activities of lead (Leucaena leucocephala) seed as affected by extraction solvent, prior dechlorophyllisation and drying methods

Cited by 45 publications

References 47 publications

Effects of Leucaena leucocephala (Lam.) de Wit Leaves Extracts in Culture of Human Umbilical Vein Cells

Effects of Leucaena leucocephala (Lam.) de Wit Leaves Extracts in Culture of Human Umbilical Vein Cells

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Isolation and biological activities of 3-hydroxy-4(1H)-pyridone

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