Antioxidant Activities of Ipomoea batatas L. Lam. (Purple Sweet Potato) Extracts Cultured in Korea

공봉주,; 한성수,; 하지훈,; 박수남,

doi:10.15230/scsk.2014.40.4.423

Cited by 2 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies showed that several antioxidants could improve EPCs growth and stem cells differentiation into EPCs [10,11]. Impaired proliferation of EPCs in cardiovascular-related disease was also able to be enhanced with antioxidant treatment [12,13]. As a prominent antioxidant, Vitamin C and E have been shown to prevent lowering the effect of TNF-α on EPCs proliferation through increased expression of phosphorylated p38 [14].…”

Section: Introductionmentioning

confidence: 99%

“…Various studies had demonstrated antioxidant properties of the Ipomoea batatas L./purple sweet potato (PSP) extract [13,17,18]. The major bioactive antioxidant constituents of PSP are anthocyanin [17] and β-carotene [18].…”

Section: Introductionmentioning

confidence: 99%

“…PSP extract has been shown to prevent endothelial dysfunction through inhibition of reactive oxygen species (ROS) and a nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) signaling pathways [19]. It is also reported that the antioxidant capacity of PSP extract is quite similar to the prominent antioxidant, l-ascorbic acid [13]. While l-ascorbic acid has been proven to prevent the decrease of EPCs proliferation due to TNFα treatment via increase of phosphorylated-p38 and 5389 genes expression levels [14], no studies are showing the effect of both l-ascorbic acid and PSP extract on the impaired EPCs from CHD patients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preliminary Study: Purple Sweet Potato Extract Seems to Be Superior to Increase the Migration of Impaired Endothelial Progenitor Cells Compared to l-Ascorbic Acid

et al. 2019

View full text Add to dashboard Cite

Impairment of the endothelial progenitor cells (EPCs) ability to proliferate and migrate in the patients with coronary heart disease (CHD) is partly caused by oxidative stress. This research evaluates the effect of treatment with Ipomoea batatas L./purple sweet potato (PSP) extract and l-ascorbic acid on the proliferation and migration of impaired EPCs. EPCs were isolated from CHD patient’s peripheral blood. EPCs culture were cultivated and divided into control (untreated), PSP extract treatment (dose 1 and 25 μg/mL), and l-ascorbic acid treatment (dose 10 and 250 μg/mL) groups for 48 h. EPCs proliferation was analyzed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell proliferation assay, and migration was evaluated with the cell migration assay kit. Statistical tests were evaluated using SPSS 25.0. This research showed that EPCs proliferation and migration was significantly higher in all PSP extract and l-ascorbic acid treatment compared to the control (p < 0.001). EPCs migration on treatment with a PSP extract dose of 25 μg/mL was significantly higher compared to the treatment with l-ascorbic acid dose of 250 μg/mL (303,000 ± 1000 compared to 215,000 ± 3000 cells, p< 0.001). In conclusion, both treatments with PSP extract and l-ascorbic acid can improve the proliferation and migration of impaired EPCs. At the dose of 25 μg/mL, PSP extract seems to be superior to the l-ascorbic acid dose of 250 μg/mL to improve EPCs migration.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preliminary Study: Purple Sweet Potato Extract Seems to Be Superior to Increase the Migration of Impaired Endothelial Progenitor Cells Compared to l-Ascorbic Acid

et al. 2019

View full text Add to dashboard Cite

show abstract

“…2,7 the antioxidant is suggested to have a beneficial effect on impaired EPCs proliferation from patients with cardiovascular disease. 7,8 Plants with antioxidant properties such as Chokeberry (Aronia melanocarpa), 9 potato shoot (Solanum tuberosum) and Marigold (Calendula officinalis) has been proven to improve impaired EPCs proliferation. 10 Similarly, vitamin C also able to prevent lowering EPCs proliferation caused by TNF-α.…”

Section: Introductionmentioning

confidence: 99%

“…10 Garlic (Allium sativum), purple sweet potato (Ipomoea batatas) extract and vitamin C have potent antioxidant capabilities. 8,11 Previous studies also have shown purple sweet potato extract and vitamin C on the EPCs from SCAD patients and identify its mechanism. 8 Hence, this research aims to identify the effect of garlic extract, purple sweet potato extract and vitamin C treatment on the EPCs and identify the involvement of ERK phosphorylation in the SCAD patient.…”

Section: Introductionmentioning

confidence: 99%

Extracellular-Signal Regulated Kinase Signalling Pathway Mediates the Increased Proliferation of EPCs Treated with Garlic (Allium sativum) Extract, Purple Sweet Potato (Ipomoea batatas) Extract and Vitamin C

Oktaviono¹,

Putri²,

Al-Farabi³

et al. 2020

View full text Add to dashboard Cite

MATERIAL AND METHODS Garlic extract, purple sweet potato extract, and vitamin C preparation Garlic and Purple sweet potato were obtained from UPT Materia Medica Batu, Indonesia and vitamin C powder was obtained from Sigma-Aldrich, USA. Purple sweet potato and garlic extract were produced with aqueous extraction method as described ABSTRACT The endothelial progenitor cell (EPCs) proliferation capability is reduced in the patient with stable coronary artery disease (SCAD). Garlic (Allium sativum), purple sweet potato (Ipomoea batatas), and vitamin C are proven antioxidant which potentially improve EPCs proliferation ability. Objective: To investigate the effect of garlic (Allium sativum), purple sweet potato (Ipomoea batatas), and vitamin C in EPCs proliferation from CAD patients and identify the involvement of Extracellular-Signal Regulated Kinase (ERK) Signalling Pathway. Material and Method: Mononuclear cells were isolated from SCAD patients and cultivated with colony-forming unit (CFU)-Hill medium and divided into untreated (control), garlic extract (10 mcg/ml and 100 mcg/ml), purple sweet potato extract (1 mcg/ml and 25 μg/ml), and vitamin C (10 μg/ml and 250 μg/ml). EPCs proliferation was measured using the MTT Assay. Results: This research shows that EPCs proliferation was increased in the treatment with garlic extract at 10 mcg/ml and 100 mcg/ml dose (0.267 ± 0,003 and 0.391 ± 0.008 ; p < 0.05), purple sweet potato extract at 1 mcg/ml and 25 μg/ml dose (0.250 ± 0.005 and 0.3562 ± 0.023 ; p < 0.001), and vitamin C at 10 μg/ml and 250 μg/ml dose (0.259 ± 0.016 and 0.306 ± 0.022 ; p < 0.001). Increased ERK expression was found in the treatment with garlic extract, purple sweet potato extract and vitamin C. Conclusion: Garlic extract, purple sweet potato extract, and vitamin C can increase EPC proliferation through the ERK signaling pathway.

show abstract

Antioxidant Activities of Ipomoea batatas L. Lam. (Purple Sweet Potato) Extracts Cultured in Korea

Cited by 2 publications

References 15 publications

Preliminary Study: Purple Sweet Potato Extract Seems to Be Superior to Increase the Migration of Impaired Endothelial Progenitor Cells Compared to l-Ascorbic Acid

Preliminary Study: Purple Sweet Potato Extract Seems to Be Superior to Increase the Migration of Impaired Endothelial Progenitor Cells Compared to l-Ascorbic Acid

Extracellular-Signal Regulated Kinase Signalling Pathway Mediates the Increased Proliferation of EPCs Treated with Garlic (Allium sativum) Extract, Purple Sweet Potato (Ipomoea batatas) Extract and Vitamin C

Contact Info

Product

Resources

About