Antiovulatory action of anordrin in the cynomolgus monkey (Macaca fascicularis)

Mehta, Rajeshwari R.; Chatterton, Robert T.

doi:10.1007/bf01850715

Cited by 9 publications

(6 citation statements)

References 7 publications

(5 reference statements)

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“…Mehta and Chatterton [ 36 ] investigated the anovulatory effect of Anordrin, a synthetic steroidal antiprogestin administered intramuscularly in sesame oil at variable doses. Mehta and Chatterton [ 36 ] discovered that a lower dose administered during the macaque menstrual cycle’s first three (3) days inhibited follicular development, which was manifested by delayed ovulation time. Furthermore, the findings of [ 36 ] contradict other findings, which report that women taking Anordrin as a postcoital contraceptive had anovulatory cycles [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…Mehta and Chatterton [ 36 ] discovered that a lower dose administered during the macaque menstrual cycle’s first three (3) days inhibited follicular development, which was manifested by delayed ovulation time. Furthermore, the findings of [ 36 ] contradict other findings, which report that women taking Anordrin as a postcoital contraceptive had anovulatory cycles [ 37 ]. However, this could be because they took the drug as early as their menstrual cycles, suggesting the reason for ovulation failure [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Long-Tailed Macaque (Macaca fascicularis) Contraception Methods: A Systematic Review

Mikail

Azizan

Noor

et al. 2023

Biology

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The contraception-based approach to wildlife management is a humane and effective alternative to population control methods. Wildlife management only has a few conventional ways to control overpopulation, such as culling, translocation, poisoning, and allowing natural death. Nevertheless, these methods usually have short-term, lethal, and unethical effects. The present systematic review aims to review the knowledge on contraception reported in long-tailed macaques as an alternative to population control. We obtained 719 records from searching CABI, PubMed, ScienceDirect, and Scopus electronic databases. After the screening and selection process, according to PRISMA guidelines, 19 articles that met the eligibility criteria were chosen. Of the 19 articles, 15 were studies on female long-tailed macaque contraception methods (six (6) hormonal and nine (9) non-hormonal). We analyzed four (4) selected articles on male Cynomolgus monkey contraception methods (two (2) hormonal and two (2) non-hormonal). One of the nine (9) articles on female long-tailed macaque contraception reports negative results. Furthermore, only two (2) studies used free-ranging long-tailed macaques as test subjects, while seventeen (17) tested on captive ones. The challenges of long-tailed macaque contraception identified in this review were the effectiveness of the contraceptive, the administration route, the economic feasibility, the distinction between captive and free-ranging Cynomolgus macaques, the choice of permanent or reversible contraception, the capability of contraceptive use for population control, and the lack of studies on the free-ranging long-tailed macaque. Notwithstanding the literature gap on long-tailed macaque contraception for population control, long-tailed macaque contraception exhibits potential as an alternative method to culling long-tailed macaque. Future research should address these obstacles to support the long-tailed macaque contraception as an alternative population control method.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Long-Tailed Macaque (Macaca fascicularis) Contraception Methods: A Systematic Review

Mikail

Azizan

Noor

et al. 2023

Biology

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show abstract

“…Luteolytic activity of anordrin has not been observed in the monkey, but anordrin has not been administered shortly after formation of the corpora lutea as it was in the rat. Nevertheless, when anordrin was given within the first 6 days of the menstrual cycle, it had a suppressive effect on progesterone production, measured as pregnanediol excretion, which was proportional to the dose administered [1]. The length of the primate luteal phase, however, was not altered by the treatment.…”

Section: Discussionmentioning

confidence: 95%

“…Previous studies in this laboratory have demonstrated that anordrin (2a,17a-diethynyl-A-nor-5a-androstane-2#,17#-diol dipropionate) and anordiol, the unesterified form, inhibit ovulation in the monkey when given as a single dose within the first 6 days of the menstrual cycle, that is, during the stage of follicular recruitment [1]. Further studies revealed that anordrin given once a month for 5 months starting on the first day of the menstrual cycle suppressed ovulation continuously for 7 -0.8 (SD) months [2].…”

Section: Introductionmentioning

confidence: 98%

Effects of the antiestrogen anordiol on ovulation and endometrial histology in the rat

Chatterton

1993

Adv Contracept

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The rat was evaluated as a model for the study of the folliculostatic properties of anordiol (2 alpha,17 alpha-diethynyl-A-nor-5 alpha-androstane-2 beta,17 beta-diol) which have been previously demonstrated in the primate. The effects in the rat were similar to those in the monkey in that anordiol: 1) extended the period of time for ovulation to occur, and 2) was effective only when administered during the early preantral stage of follicular development. The effect was different in that anordiol resulted in more complete luteolysis of newly formed corpora lutea. The presence of cornified cells in the vaginal smears 2 days after treatment with anordiol was a result of luteolysis and an intrinsic estrogenic activity of anordiol. Ovulation occurred on the first estrus after treatment whether the animals received 13 treatments every 5 days or only a single dose of anordiol. The uterine responses were characteristic of an antiestrogenic action of anordiol. It is concluded that the rat is a reasonable model for studies of the mechanism(s) of action of anordiol.

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“…Previous studies from this laboratory have shown that anordrin (anordiol dipropionate) and anordiol inhibit ovulation in the mature monkey [1,2] and rat [31. Biological and biochemical studies have shown that anordiol is a weak estrogen with antiestrogenic activity in the mature animal [3][4][5][6]. Tamoxifen (TA) is a non-steroidal triphenylethylene derivative with antiestrogenic activity.…”

Section: Introductionmentioning

confidence: 99%

Effect of anordiol on ovarian hormone secretion, ovulation, and uterine and vaginal responses in the immature rat

Chatterton

1994

Adv Contracept

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The purpose of this investigation was to determine the estrogenic and antiestrogenic activities of the potential contraceptive agent anordiol in the immature rat. A dose of 2.45 mumol of anordiol (AD), estradiol (E2), clomiphene citrate (CC), tamoxifen (TA), or the vehicle alone was administered to rats on the 25th and 29th days of age. Serum hormones were measured between 16:00 and 17:00 on days 30, 31, and 32; organ weights were determined on day 32. Anordiol and estradiol treatments significantly increased ovarian and uterine weight and serum LH concentrations, but CC and TA had no effect on these parameters. Vaginal cornification occurred before day 32 in all rats receiving anordiol or estradiol and in 3/5 and 4/5 rats receiving CC and TA, respectively, but not in control rats. Based on serum progesterone levels, ovulation was induced only in rats receiving anordiol or estradiol. All of the compounds tested significantly increased serum testosterone above levels in control animals, but both AD and E2 induced ovulation without a further increase in serum testosterone. We conclude that in the immature rat anordiol produces estrogenic responses in the vagina, uterus and in the hypothalamic-pituitary-ovarian axis, whereas TA and CC are estrogenic only on the vaginal and uterine epithelium.

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Antiovulatory action of anordrin in the cynomolgus monkey (Macaca fascicularis)

Cited by 9 publications

References 7 publications

Long-Tailed Macaque (Macaca fascicularis) Contraception Methods: A Systematic Review

Long-Tailed Macaque (Macaca fascicularis) Contraception Methods: A Systematic Review

Effects of the antiestrogen anordiol on ovulation and endometrial histology in the rat

Effect of anordiol on ovarian hormone secretion, ovulation, and uterine and vaginal responses in the immature rat

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