Antiosteoporotic chemical constituents from Er-Xian Decoction, a traditional Chinese herbal formula

Qin, Lu‐Ping; Han, Ting; Zhang, Qiaoyan; Cao, Da-Peng; Ni, Hua; Rahman, Khalid; Zheng, Huabin

doi:10.1016/j.jep.2008.04.009

Cited by 108 publications

(67 citation statements)

References 14 publications

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“…Icariin is the main flavonoid present in Epimedium brevicornum, used for herbal quality control (Chinese Pharmacopoeia Commission, 2010), and is considered the major bioactive component of this plant (Meng et al, 2005;Ma et al, 2011). Several studies have shown that both Epimedium brevicornum and icariin have antiosteoporotic effects in vitro and in vivo by stimulating osteoblast proliferation and function; these findings support the wide use of Epimedium brevicornum in many Chinese formulas for treating osteoporosis (Zhang et al, 2007Qin et al, 2008;Nian et al, 2009;Hsieh et al, 2010). Additionally, Cuscuta chinensis, Rhizoma drynariae, Ligustrum lucidum, and Polygonum multiflorum exhibit antiosteoporotic effects both in vitro and in vivo, and are also widely used in many Chinese formulas to treat osteoporosis (Li et al, 2001;Zhang et al, 2006).…”

Section: Introductionmentioning

confidence: 77%

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Yang

Guo

et al. 2013

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 77%

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Yang

Guo

et al. 2013

Journal of Ethnopharmacology

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“…Traditional herbal medicines are mixtures of active ingredients affecting bone cells differently. They contain stimulative ingredients on osteoblast differentiation increasing bone formation and inhibitory ingredients on osteoclast differentiation reducing bone loss, which contribute together to the antiosteoporotic effect of herbal medicine (Qin et al 2008). Extracts of medicinal herbs (Rehmannia glutinosa Libosch and Angelicae gigantis radix) of which SHT is composed stimulate osteoblast proliferation and activity while inhibiting osteoclast differentiation or bone loss in OVX rats (Oh et al 2003;Kil et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of Ssanghwa-tang on bone loss in ovariectomized rats

Shim

Lee

et al. 2010

Animal Cells and Systems

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Ssanghwa-tang (SHT) is a traditional Korean herbal medicine widely prescribed to decrease fatigue following an illness. The purpose of this study was to investigate the effects of SHT on osteoclast differentiation in vitro, and on bone loss in ovariectomized (OVX) rats in vivo. SHT significantly reduced the receptor activator for the nuclear factor kB (NF-kB) ligand (RANKL)-induced tartrate-resistant acid phosphatase (TRAP) activity, and multinucleated osteoclast formation in RAW264.7 cells without affecting cell viability. In addition, SHT significantly attenuated RANKL-induced mRNA expression levels of c-Src and cathepsin K. To examine the in vivo effect of SHT on OVX-induced bone loss in OVX rats, we administered SHT (0.6 g/kg BID) orally to OVX rats for 12 weeks. SHT administration significantly blocked OVX-induced decrease of femoral bone mineral density (BMD) and femoral trabeculae in OVX rats. In conclusion, these results suggest that SHT treatment effectively prevents OVX-induced bone loss, and this effect may result from its inhibitory effect on osteoclast differentiation.

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“…Osteoporosis is one of the common bone diseases characterized by a systemic impairment of bone mass and high risk of fractures (Qin et al, 2008;Zhang et al, 2008). It is estimated that about 30% of postmenopausal women in the USA and Europe have osteoporosis, and osteoporosis is one of the major health problems of elderly women (Bock & Felsenberg, 2008;Tüzün et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Anti-osteoporotic activity of puerarin 6″-O-xyloside on ovariectomized mice and its potential mechanism

Li¹,

Bing-pu²,

Pang

et al. 2015

Pharmaceutical Biology

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Context: Osteoporosis is one of the most common bone diseases, and radix of Pueraria lobata (Willd.) Ohwi possesses an obvious therapeutical effect on postmenopausal osteoporosis. Objective: This study investigates the anti-osteoporotic activity of the puerarin 6 00 -O-xyloside (PXY) on ovariectomized mice and its related mechanism. Materials and methods: Osteoporotic mice model was established by ovariectomy (OVX). A total of 50 mice were divided into five groups (n ¼ 10): sham, OVX group, PXY treatment groups (20, 40, and 60 mg/kg/d, i.p.). After 12 weeks' treatment, body weights were recorded. Then, mice were sacrificed, and serum samples were collected to determine the blood calcium, blood phosphorus, alkaline phosphatase (ALP), and osteoprotegerin (OPG) concentrations and uterine index was assayed. The thigh-bones of mice were collected to evaluate histopathological changes. In the in vitro experiment, the effect of PXY on osteoblasts' proliferation was evaluated and western blotting was performed to determine expressions of OPG and the receptor activators of NF-B ligand (RANKL), as well as the ratio of OPG/RANKL. Results: PXY (40 and 60 mg/kg/d, i.p.) obviously decreased body weights and increased uterine index of OVX (p50.05), and improved osteoporotic syndromes of OVX mice; PXY also significantly increased the concentrations of blood calcium, blood phosphorus, ALP, and OPG of OVX mice (p50.05); moreover, PXY obviously up-regulated the ratio of OPG/RANKL (p50.05). Conclusion: Our results demonstrated that the puerarin 6 00 -O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice.

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Antiosteoporotic chemical constituents from Er-Xian Decoction, a traditional Chinese herbal formula

Cited by 108 publications

References 14 publications

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Inhibitory effect of Ssanghwa-tang on bone loss in ovariectomized rats

Anti-osteoporotic activity of puerarin 6″-O-xyloside on ovariectomized mice and its potential mechanism

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