Antioedema and analgesic actions of Diodia scandens extract in rats and mice

Abstract

An extract of Diodia scandens obtained by petroleum ether extraction of the leaves was screened for pharmacological actions. The extract evinced a marked antiinflammatory effect in rats, causing a dose-related and sustained inhibition of the increase in rat paw circumference caused by subplantar injection of a phlogistic agent. In addition, the extract increased the threshold of pain stimulus in mice. The extract significantly protected rats from aspirin, indomethacin and reserpine induced ulcers. These results revealed that the plant, Diodia scandens has potential medicinal value.

Correlation between polyphenol content and anti-inflammatory activity ofVerbascum phlomoides(mullein)

“…On the other hand, the inhibition of adhesion molecules in TNF-a stimulated HUVECs was achieved only at high doses, and moreover the extract showed no anti-inflammatory effect on rat paw edema assay. The method carried out in this study, egg-white-induced inflammation, is similar to that produced by carrageenan (Akah et al, 1993) and the mechanism involved in this assay implies the release of several mediators such as histamine, serotonin and bradykinin in the initial phase (0-1 h), and an increase in the production of prostaglandins through the activation of cyclooxygenase-2 and release of nitric oxide in the later phase (1-6 h) (Crunkhorn & Meacock, 1971). …”

Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract

“…Although the ideal model for medicines against pelvic inflammation is by surgery, to make an animal model of pelvic inflammation, some anti-inflammatory and anti-pain animal model are still useful to screen medicine for curing pelvic inflammation. We used several animal models such as the rat egg-albumin edema model to study the antiinflammatory activity (Akah et al, 1993;Akah and Nwambie, 1994;Amos et al, 2002), and acetic acid-induced mice abdominal writhing (Koster et al, 1959) and mouse hot-plate model (Adzu et al, 2003) to study the anti-nociceptive effect. All these animal models clearly demonstrate that the aqueous extract of Smilax china is effective.…”

Pharmacological evidence favouring the use of Nauclea latifolia in malaria ethnopharmacy: Effects against nociception, inflammation, and pyrexia in rats and mice

“…In testing for the effects of the extract against inflammation, the method of Akah et al (1993), was adopted. Briefly, rats were grouped into five (n = 6).…”