Antiobesity Activity of &lt;i&gt;Vigna nakashimae&lt;/i&gt; Extract in High-Fat Diet-Induced Obesity

Son, Yonghae; Nam, Jeongsu; Jang, Min-Kyung; Jung, In-Ah; Cho, Su-In; Jung, Minyoung

doi:10.1271/bbb.120755

Cited by 18 publications

(15 citation statements)

References 19 publications

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“…C57BL/6J mice were fed an HFD and orally administered VN extracts [100 mg/(kg$day -1 ), 300 mg/(kg$day -1 )] daily for 16 weeks. Consistent with previous results, 11 the weight gain in the VN extract-treated HFD mice was significantly less than that in HFD control mice (Fig. 1A).…”

Section: Vn Extract Inhibited Hfd-induced Hepatic Steatosis and Protesupporting

confidence: 93%

“…Previous studies reported that Vigna species exert several pharmacological effects, [11][12][13][14] including lowering glucose concentration and inhibiting obesity. However, antihepatic steatosis effect has not yet been reported.…”

Section: Discussionmentioning

confidence: 99%

“…11 A voucher specimen was deposited at the National Institute of Agricultural Biotechnology. The dried seeds of VN (3.0 kg) were pulverized using a grinder and extracted with 10 L of 80% methanol for 3 days at room temperature.…”

Section: Preparation Of Vn Extractmentioning

confidence: 99%

“…8,9 Previously, we reported that Vigna nakashimae (VN), another species of Vigna that is widely cultivated in Korea, has antidiabetic effects in db/db mice via inhibition of a-glucosidase activity 10 and antiobesity effects in HFD obese mice. 11 Recently, the search for appropriate hepatic steatosis agents has focused on plants used in traditional medicine. The Vigna species of legumes has been reported to have polyphenols that suppress TG accumulation in hepatocytes.…”

Section: Introductionmentioning

confidence: 99%

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Vigna nakashimae Extract Prevents Hepatic Steatosis in Obese Mice Fed High-Fat Diets

Son

Jang

Jung

2014

Journal of Medicinal Food

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Vigna species are important food resources and are traditionally used for the treatment of various diseases. In this study, we examined the inhibitory effects of Vigna nakashimae (VN) extract on high-fat diet (HFD)-induced hepatic steatosis and elucidated the molecular mechanisms. C57BL/6J mice were fed an HFD with or without VN extract for 16 weeks. VN extract decreased HFD-induced body weight, liver weight, hepatic lipid accumulation, and plasma alanine aminotransferase, and suppressed oxidative stress and inflammation associated with hepatitis. VN extract decreased plasma lipid levels and the expression of lipogenic genes in the livers of HFD-fed mice. VN extract significantly increased phosphorylation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) and acetyl-CoA carboxylase, and expression of fatty acid oxidation genes in the liver of VN-treated HFD mice and HepG2 cells. Further, VN extract inhibited insulin or glucose-stimulated lipogenesis in HepG2 cells. In conclusion, VN extract prevents HFD-induced hepatic steatosis and lipotoxicity through AMPK activation.

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Section: Vn Extract Inhibited Hfd-induced Hepatic Steatosis and Protesupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Preparation Of Vn Extractmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vigna nakashimae Extract Prevents Hepatic Steatosis in Obese Mice Fed High-Fat Diets

Son

Jang

Jung

2014

Journal of Medicinal Food

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“…It is known to be a risk factor for numerous metabolic complaints such as diabetes, atherosclerosis, hyperlipidemia, and cancer [2, 3]. Consumption of high-fat diet causes a leading obesity and obesity-related complications including hyperlipidemia and oxidative stress [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High-Fat Diet-Fed Rats

Tuzcu

Orhan

Şahin

et al. 2017

Oxidative Medicine and Cellular Longevity

103

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We evaluated the effects of cinnamon polyphenol extract on hepatic transcription factors expressions including SREBP-1c and LXR-α in rats fed high fat diet (HFD). Twenty-eight Wistar rats were allocated into four groups: (i) normal control: animals fed with normal chow; (ii) cinnamon: animals supplemented with cinnamon polyphenol; (iii) HFD: animals fed a high-fat diet; and (iv) HFD + cinnamon: animals fed a high-fat diet and treated with cinnamon polyphenol. Obesity was linked to hyperglycemia, hyperlipidemia, and oxidative stress as imitated by elevated serum glucose, lipid profile, and serum and liver malondialdehyde (MDA) concentrations. Cinnamon polyphenol decreased body weight, visceral fat, liver weight and serum glucose and insulin concentrations, liver antioxidant enzymes, and lipid profile (P < 0.05) and reduced serum and liver MDA concentration compared to HFD rats (P < 0.05). Cinnamon polyphenol also suppressed the hepatic SREBP-1c, LXR-α, ACLY, FAS, and NF-κB p65 expressions and enhanced the PPAR-α, IRS-1, Nrf2, and HO-1 expressions in the HFD rat livers (P < 0.05). In conclusion, cinnamon polyphenol reduces the hyperlipidemia, inflammation, and oxidative stress through activating transcription factors and antioxidative defense signaling pathway in HFD rat liver.

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Supplementation of scopoletin improves insulin sensitivity by attenuating the derangements of insulin signaling through AMPK

et al. 2018

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Scopoletin (SPL), a phenolic coumarin, is reported to regulate glucose metabolism. This study is initiated to substantiate the action of SPL on the regulation of insulin signaling in insulin resistant RIN5f cells and high fat, high fructose diet (HFFD)-fed rat model. Adult male Sprague Dawley rats were fed HFFD for 45 days to induce type 2 diabetes and then treated or untreated with SPL for the next 45 days. The levels of glucose, insulin, lipid profile, oxidative stress markers along with insulin signaling and AMPK protein expressions were examined at the end of 90 days. SPL lowered the levels of plasma glucose, insulin, and lipids which were increased in HFFD-fed rats. HFFD intake suppressed the activities of antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase; however, they were reversed by SPL supplementation, which reduced TBARS, lipid hydroperoxide, and protein carbonyl levels both in plasma and pancreas. SPL supplementation significantly activated insulin receptor substrate 1 (IRS1), phosphatidyl inositol 3-kinase (PI3K), and protein kinase B (Akt) phosphorylation which was suppressed in HFFD rats due to lipotoxicity. Moreover, SPL significantly activated AMPK and enhanced the association of IRS1-PI3K-Akt compared to the control group. The results revealed that SPL alleviated T2D induced by HFFD by escalating the antioxidant levels and through insulin signaling regulation. We conclude that SPL can improve insulin signaling through AMPK, thereby confirming the role of SPL as an AMPK activator.

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Antiobesity Activity of <i>Vigna nakashimae</i> Extract in High-Fat Diet-Induced Obesity

Cited by 18 publications

References 19 publications

Vigna nakashimae Extract Prevents Hepatic Steatosis in Obese Mice Fed High-Fat Diets

Vigna nakashimae Extract Prevents Hepatic Steatosis in Obese Mice Fed High-Fat Diets

Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High-Fat Diet-Fed Rats

Supplementation of scopoletin improves insulin sensitivity by attenuating the derangements of insulin signaling through AMPK

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