Antinucleolar Antibodies

Ritchie, Robert F.

doi:10.1056/nejm197005212822104

N Engl J Med

1970

DOI: 10.1056/nejm197005212822104

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Antinucleolar Antibodies

Robert F. Ritchie¹

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1975

1989

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Cited by 67 publications

(1 citation statement)

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“…Autoantibodies against the nucleolus are produced spontaneously by patients with collagen vascular diseases and, among such patients, are associated particularly with progressive systemic sclerosis (scleroderma) (1)(2)(3). Sera from such patients stain nucleoli in distinctive patterns, indicating the presence of autoantibodies against a variety of nucleolar components.…”

mentioning

confidence: 99%

Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice.

Reuter

Tessars

Vohr

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

108

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Autoantibodies to nucleolar components are a common serological feature of patients suffering from scleroderma, a collagen vascular autoimmune disease. While animal models, which spontaneously develop abundant antinucleolar antibodies, have not yet been described, high titers of such antibodies may be induced by treating susceptible strains of mice with mercuric chloride. We have identified the nucleolar autoantigen against which the HgCI2-induced IgG autoantibodies from mice of strain B10.S are directed. It is a protein with an apparent molecular mass of 36 kDa and a pI value of =8.6, which is associated with the nucleolar small nuclear RNA U3, and by these criteria must be identical with a polypeptide called fibrillarin. It is striking that scleroderma patients spontaneously produce autoantibodies against the same U3 ribonucleoprotein (RNP). The HgCl2-induced murine and the scleroderma-specific human anti-U3 RNP autoantibodies were indistinguishable in their reactivities toward fibrillarin. They further resemble each other insofar as both recognize epitopes on the 36-kDa protein, which have been highly conserved throughout evolution. Our results provide a basis to investigate at the molecular level whether similar immunoregulatory dysfunctions may lead to the preferential anti-U3 RNP autoantibody production in the animal model and in scleroderma patients.

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mentioning

confidence: 99%

Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice.

Reuter

Tessars

Vohr

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

108

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Antinuclear Antibodies

Burnham¹

1975

Arch Dermatol

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Diagnosis of Systemic Lupus Erythematosus

Nisengard¹,

Jabłońska²,

Chorzelski³

et al. 1975

Arch Dermatol

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Antinucleolar Antibodies

Cited by 67 publications

References 25 publications

Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice.

Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice.

Antinuclear Antibodies

Diagnosis of Systemic Lupus Erythematosus

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