Antinuclear antibodies in mycobacterium tuberculosis infection

Ganesh, Ramaswamy; Ramalingam, Vanitha; Raja, T.; Vasanthi, Thiruvengadam

doi:10.1007/s12098-008-0178-3

Cited by 5 publications

(5 citation statements)

References 2 publications

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“…A number of studies connecting TB with AI investigated the AAB characteristics of AIDs. The list of AABs includes rheumatoid factor (RF), antinuclear antibodies (ANA), anti-dsDNA AAB, anticardiolipin antibody (ACA; IgM isotype predominant), antineutrophil cytoplasmic antibodies (ANCA), and anticyclic citrullinated peptide (anti-CCP) [8,9,11,48,50,[72][73][74][75][76][77][78] (Table 1). rheumatoid factor (RF) rheumatoid arthritis, Sjögren's syndrome [7,11,76] antinuclear antibodies (ANA) SLE, Sjögren's syndrome, scleroderma, dermatomyositis [7,8,70,72,73] anti-dsDNA antibodies SLE [10,11,48,50,77] antineutrophilic cytoplasmatic antibodies (ANCA) ANCA-associated systemic vasculitis [11,74,75] anticyclic citrullinated peptide (anti-CCP) rheumatoid arthritis [76] anti-Scl-70, antihistone antibodies systemic sclerosis, SLE [10] antiphospholipid antibodies (aPL): the lupus anticoagulant (LA), anticardiolipin antibody (ACA), anti-beta 2 glycoprotein 1 (anti-ß2 GPI), anti-prothrombin antiphospholipid syndrome, SLE [21,22,24] anticardiolipin antibody (ACA; IgM) SLE, antiphospholipid syndrome [8,10,11,50] antibodies against β2 glycoprotein IgG antiphospholipid syndrome, SLE [11] antibodies against proteinase 3, myeloperoxidase, bactericidal/permeabil...…”

Section: Occurrence Of Aabs In Active Tb Patient Seramentioning

confidence: 99%

“…The prevalence of anti-CCP and IgM RF was found in sera of TB patients [50,75]. Several reports demonstrated the presence in the active TB patients' antinuclear antibodies [7,8,50,72], AAB to double-stranded DNA (dsDNA) [10,48,50,77], which are characteristic of SLE. ANCAs, also typical for autoimmune diseases, were revealed in TB patients by different methods and results did not depend on the stage of disease, category of tuberculosis, concomitant diseases, or drug therapy [74].…”

Section: Occurrence Of Aabs In Active Tb Patient Seramentioning

confidence: 99%

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Tuberculosis and Autoimmunity

2022

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Tuberculosis remains a common and dangerous chronic bacterial infection worldwide. It is long-established that pathogenesis of many autoimmune diseases is mainly promoted by inadequate immune responses to bacterial agents, among them Mycobacterium tuberculosis. Tuberculosis is a multifaceted process having many different outcomes and complications. Autoimmunity is one of the processes characteristic of tuberculosis; the presence of autoantibodies was documented by a large amount of evidence. The role of autoantibodies in pathogenesis of tuberculosis is not quite clear and widely disputed. They are regarded as: (1) a result of imbalanced immune response being reactive in nature, (2) a critical part of TB pathogenicity, (3) a beginning of autoimmune disease, (4) a protective mechanism helping to eliminate microbes and infected cells, and (5) playing dual role, pathogenic and protective. There is no single autoimmunity-mechanism development in tuberculosis; different pathways may be suggested. It may be excessive cell death and insufficient clearance of dead cells, impaired autophagy, enhanced activation of macrophages and dendritic cells, environmental influences such as vitamin D insufficiency, and genetic polymorphism, both of Mycobacterium tuberculosis and host.

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Section: Occurrence Of Aabs In Active Tb Patient Seramentioning

confidence: 99%

Section: Occurrence Of Aabs In Active Tb Patient Seramentioning

confidence: 99%

Tuberculosis and Autoimmunity

2022

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“…Autoantibodies, for example, ANA and ANCA, have been reported in TB patients previously in the literature as well. [ 4 5 ] These findings have always sparked interest whether Mycobacterium infection triggers the formation of these antibodies. One of the hypotheses is that the cell wall of the TB bacillus stimulates the release of oxygen metabolites from neutrophils.…”

Section: Discussionmentioning

confidence: 99%

“…This leads to the release of lysosomal enzymes from the neutrophils and thereafter the development of autoantibodies against these granular components. [ 4 ] A study by Pradhan et al . reported ANA and ANCA positivity in 24% and 34% patients, respectively.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary tuberculosis presenting as diffuse alveolar hemorrhage: Believe it or not

et al. 2018

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Diffuse alveolar hemorrhage (DAH) has been rarely reported with pulmonary infections and even rarer with pulmonary tuberculosis (PTB). We hereby report the case of a 31-year-old male, a known case of ankylosing spondylitis, who presented with clinical and radiological features consistent with DAH. Initial partial improvement with steroids was followed by a microbiological diagnosis of tuberculosis (TB). Starting of antituberculous treatment was followed by complete clinical improvement. This leads to a thought-provoking possible association between the two pathologies, DAH and PTB, if any.

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“…It is important to note here that TB can generate several antibodies-ANA, dsDNA, ANCA etc. Thus no laboratory test should be interpreted in isolation [15]. vi.…”

Section: Differential Diagnosismentioning

confidence: 99%

Approach to a Child with Monoarthritis

Prabhu

Balan

2010

Indian J Pediatr

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Arthritis in childhood is common. The pattern, presentation and duration of arthritis help differentiate between the various possible diagnoses. When only one joint is involved, i.e., monoarthritis, it may be difficult to make a diagnosis as there are many possibilities both acute and chronic in nature. A detailed history and clinical examination is important to reach a correct diagnosis and the single most important investigation when a child presents acutely is a joint aspiration to rule out septic arthritis that may destroy the joint in hours. Inflammatory markers, antinuclear antibody testing, test for tuberculosis and imaging (in specific cases) play an important role in the diagnosis of a child that presents with a chronic monoarthritis. In this article we provide a clinical approach to the diagnosis of monoarthritis in a child.

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Antinuclear antibodies in mycobacterium tuberculosis infection

Cited by 5 publications

References 2 publications

Tuberculosis and Autoimmunity

Tuberculosis and Autoimmunity

Pulmonary tuberculosis presenting as diffuse alveolar hemorrhage: Believe it or not

Approach to a Child with Monoarthritis

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