Antinuclear antibodies in healthy aging people: a prospective study

Xavier, Ricardo Machado; Yamauchi, Yasutaka; Nakamura, Morihiko; Tanigawa, Yoshinobu; Ishikura, Hiroto; Takemoto, Tsunematsu; Kobayashi, Shotai

doi:10.1016/0047-6374(94)01532-q

Cited by 67 publications

(45 citation statements)

References 22 publications

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“…Serum ANA are characteristic for connective tissue diseases, but their specificity is low. Antinuclear antibodies appear quite common among patients with chronic infections, malignancies and even in healthy subjects, particularly in the elderly [70,71]. Nevertheless, despite choosing relatively high cut-off titre (1:160), the ANA prevalence in our AAD cohort exceeds their 10% frequency reported for the general Polish population of healthy elderly over 85 years of age [35].…”

Section: Discussionmentioning

confidence: 90%

Screening for associated autoimmune disorders in Polish patients with Addison’s disease

Fichna

Gryczyńska

et al. 2010

Endocr

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Autoimmune Addison's disease (AAD) is the main reason of primary adrenal failure. More than a half of patients display additional autoimmune conditions, which represent a considerable clinical concern. This study aimed to investigate the prevalence of concomitant autoimmune disorders in 85 Polish AAD patients (61 females, 24 males). Mean age at AAD onset was 34.6 ± 12.6 years, significantly earlier in males (P < 0.001). Sixty-nine patients presented positive serum antibodies to 21-hydroxylase and shorter AAD duration than those with negative results (P = 0.027). Seventy-three subjects suffered from coexisting autoimmune disorders. Serum autoantibodies against thyreoperoxidase, thyroglobulin, TSH receptor, glutamic acid decarboxylase, insulin, tyrosine phosphatase-like protein IA2, parietal cell H(+)/K(+)-ATPase, intrinsic factor and tissue transglutaminase were detectable in 71.8, 41.2, 4.7, 21.0, 4.9, 2.5, 49.4, 12.0 and 3.5% of patients, respectively. Antinuclear antibodies were found in 12.5%. Thyroid autoimmunity was most common (46 subjects with lymphocytic thyroiditis, 19 with Graves' disease), followed by atrophic gastritis (29.4%), pernicious anaemia (11.8%), hypergonadotropic hypogonadism (8.2%), vitiligo (8.2%), type 1 diabetes (7.1%), celiac disease (3.5%) and alopecia (2.4%). Gender differences were observed only for thyroid autoimmunity. Current study confirms particular tendency of AAD patients to develop other autoimmune disorders. Active search for concomitant conditions is warranted to prevent serious complications.

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Section: Discussionmentioning

confidence: 90%

Screening for associated autoimmune disorders in Polish patients with Addison’s disease

Fichna

Gryczyńska

et al. 2010

Endocr

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“…A feature of immunosenescence is an increase in autoantibody levels to a variety of antigens with increasing age, as reported in several studies (35)(36)(37); in addition, women display a different pattern of autoimmune diseases relative to men (38). To achieve a reliable comparison between a cancer and a control population, patients with SCLC were therefore matched by age and gender to a normal healthy control population.…”

Section: Discussionmentioning

confidence: 99%

Immunobiomarkers in Small Cell Lung Cancer: Potential Early Cancer Signals

Chapman

Thorpe

Murray

et al. 2011

Clinical Cancer Research

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Purpose: We investigated the presence of autoantibodies as immunobiomarkers to a panel of tumorassociated antigens in a group of individuals with small cell lung cancer (SCLC), a disease group that has a poor overall cancer prognosis and therefore may benefit most from early diagnosis.Experimental Design: Sera from 243 patients with confirmed SCLC and normal controls matched for age, sex, and smoking history were analyzed for the presence of these early immunobiomarkers (i.e., autoantibodies to p53, CAGE, NY-ESO-1, GBU4-5, Annexin I, SOX2, and Hu-D) by ELISA.Results: Autoantibodies were seen to at least 1 of 6 antigens in 55% of all the SCLC patients' sera tested, with a specificity of 90% compared with controls. Using a higher assay cutoff to achieve a specificity of 99%, autoantibodies were still detectable in 42% of SCLC patients (receiver operator characteristic area under the curve ¼ 0.76). There was no significant difference in sensitivity when analyzed by stage of the cancer or by patient age or gender. The frequency of autoantibodies to individual antigens varied, ranging from 4% for GBU4-5 to 35% for SOX2. Levels of Annexin I autoantibodies were not elevated in patients with SCLC. Antibodies were also detected in 4 separate patients whose sera were taken up to 3 months before tumor diagnosis.Conclusion: The presence of an autoantibody to one or more cancer-associated antigens may provide an important addition to the armamentarium available to the clinician to aid early detection of SCLC in high-risk individuals.

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“…Thus, it is speculated that there might be a common mechanism that causes renal, cardiovascular and collagen diseases. Coincidently, the prevalence of ANA and microalbuminuria is increasing along with aging [6,9]. However, it is unknown whether ANA is associated with microalbuminuria.…”

Section: Introductionmentioning

confidence: 97%