Antinuclear antibodies and interleukin responses in patients with Schistosoma japonicum infection

Abstract

Schistosomiasis poses a serious threat to public health, and the infection will develop into chronic and advanced late-stage disease if not treated. Apart from the clinical signs due to immune reactions to schistosome eggs trapped in host tissues, it also increases the risk for the development of autoimmunity reflected by dysfunctional, auto-reactive antibodies. Antinuclear antibodies (ANA) have been reported in schistosomiasis due to S. mansoni and S. haematobium. We demonstrate ANA in schistosomiasis japonica and explore the relationship between this infection and autoimmune disease by measuring ANA and interleukin (IL)-10, IL-12 and IL-17 responses in the sera of 125 Chinese patients with different stages of schistosomiasis japonica. The incidence rates of ANA in the patients with acute, chronic and late stages of schistosomiasis infection were 6.7%, 23.3% and 70.0%, respectively, with statistically significant differences between each stage (P = 0.000). IL-17 concentrations were high at the acute stage of schistosomiasis compared to the other stages of the disease (P = 0.000). This pattern was also seen for IL-10 and IL-12 concentrations (P = 0.01). IL concentrations in patients in the chronic and late stages of the disease were low and showed no difference compared to the healthy adults.

Evidence of Anti-Double Stranded Dna Antibodies and C-Reactive Protein in Egyptian Patients With High Anti-Schistosoma Mansoni Antibody Titer

“…Previous studies on schistosomiasis have shown a positive correlation be-tween CRP and Schistosome infection (Coutinho et al, 2006;Garza, 2010;Amin et al, 2019). Also, schistosomiasis showed positive relationship between other serum inflammatory biomarkers and autoreactive antibodies, as Chitinase 3-Like 1 protein (YKL-40-25) and IL17 (Wang et al, 2018). However, Sinkala et al (2016) did not find difference in CRP levels between schistosomiasis patients and healthy control.…”

Higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis

“…Chen et al 22 found that γδ T cells are the main IL‐17‐producing cells in PBMCs and that IL‐17 contributes to granulomatous inflammatory and fibrosing reactions during S japonica infection. Wang et al 23 found that IL‐17 concentrations were higher at the acute stage of schistosomiasis compared with that in the other stages. Our findings agreed with the reduction of IL‐17 in the advanced stage of infection observed in the mouse model, which might be because the γδ T cells did not produce any IL‐17 in the late stage of infection.…”

Pathogenic Interleukin-10 Receptor Alpha Variants in Humans — Balancing Natural Selection and Clinical Implications

“…Serum IL-10 concentrations of 44.8 pg/mL in the acute stage of Schistosoma japonicum infected patients [ 48 ] are lower than those in solution concentrations used to validate the biological effects of IL10RA variants in vitro. However, IL-10 concentrations in tissue microenvironment are likely higher, and in vitro IL-10 stimulation may not precisely reflect in vivo cytokine–cytokine receptor and producer–consumer stoichiometry as described for other cytokines such as IL-2 [ 64 ].…”

“…Strong evidence that IL-10 signaling restricts host protective immune responses is available for phlebovirus infection of the Bunyaviridae family and Schistosomiasis japonicum (Schistosoma japonicum). In vitro experimental evidence additionally suggests a beneficial role for reduced IL-10 signaling in diseases including Filariasis (Brugia malayi), Capillariasis intestinal (Capillaria philippinensis), Opisthorchiasis (Opisthorchis felineaus) Clonorchiasis (Clonorchis sinensis), and Echinostomiasis (Echinostoma caproni) [44][45][46][47][48][49][50][51][52][53][54][55] (Fig. 6C).…”