Antinociceptive properties of the aqueous and methanol extracts of the stem bark of Petersianthus macrocarpus (P. Beauv.) Liben (Lecythidaceae) in mice

Bomba, Francis Desire Tatsinkou; Wandji, Bibiane Aimée; Piegang, Basile Nganmegne; Awouafack, Maurice D.; Sriram, Dharmarajan; Yogeeswari, Perumal; Kim, Albert; Nguelefack, Télesphore Benoît

doi:10.1016/j.jep.2015.08.004

Cited by 15 publications

(5 citation statements)

References 21 publications

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“…In the presence of naloxone which is known to bind specifically to opioid receptors, the effect of Paullinia pinnata aqueous extract (200 mg/kg) became less efficient to reduce the pain only during the inflammatory phase, meanwhile tramadol, a reference morphinomimetic drug, failed to significantly reduce the licking time during both phases. Similar result was obtained by Tatsinkou et al [24]. on antinociceptive properties of the aqueous and methanol extracts of stem bark of Petersianthus macrocarpus.…”

Section: Discussionsupporting

confidence: 90%

“…The present results indicated that the extract increased latency time at all point time and all doses. Previous study showed similar results [24].…”

Section: Discussionsupporting

confidence: 80%

“…In the model of acid acetic induced abdominal writhing which is commonly known as a typical visceral, tissues and muscles pain model [22], the pain is mainly due to the direct stimulation of the peripheral channels fibres like δ and C fibres which transmit the nociception message. The algic process leads to release arachidonic acid and by cyclooxygenase pathway the nociception mediators biosynthesis such as Prostaglandin, bradykinin, cytokine (TNF, IL and IFN) [23,24]. Thus, the analgesic effects of the aqueous extract of Paullinia pinnata in acid acetic abdominal constrictions could be attributed, partly, to the inhibition of biosynthesises of endogenous mediators, and also could be due to its anti-inflammatory effect by inhibition of algic cytokines as in the visceral pain model.…”

Section: Discussionmentioning

confidence: 99%

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Analgesic and acute inflammation properties of the aqueous extract of dried leaves of Paullinia Pinnata (Sapindaceae) Linn

Patience¹,

Brice²,

Julia³

et al. 2017

ijpm

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Inflammation is frequently associated with pain. Plants continue to be major resources for therapeutic compounds against various diseases including inflammation and pain. Paullinia Pinnata is used to treat several diseases, including rheumatism and abdominal pain. This study was undertaken to assess the analgesic and anti-inflammatory effects of Paullinia Pinnata. The analgesic activity was evaluated by using behaviour pain model in mice. The anti-inflammatory activity was carried out by using carrageenan, dextran, histamine and serotonin induced inflammation in rat. The extract was administered orally at a dose of 200 and 400 mg/kg. The results showed that the extract significantly (P< 0.001) reduced the number of writhing induced by the acid acetic. The aqueous extract reduced significantly (P< 0.001) the paw licking time in formalin model. The effect of the extract (200mg/kg) was significantly (P< 0.001) reduced in the presence of naloxone, during the inflammatory phase. In addition, the extract significantly (P< 0.05) increase latency time at all point time and all doses on nociception induced by hot plate. Concerning inflammation induced by carrageenan and dextran, the extract significantly (P< 0.001) inhibited oedema during the experimental time at the dose of 200 mg/kg. The results suggested that Paullinia pinnata aqueous extract possess analgesic activities which may interfere in both peripheral and central pathway. The anti-inflammatory activities may be mediated by either inhibiting or by blocking the release of vasoactive substances like histamine, serotonin, kinins and prostaglandins. These results justify the traditional use of the plant in the treatment of pain and inflammation.

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Section: Discussionsupporting

confidence: 90%

“…The present results indicated that the extract increased latency time at all point time and all doses. Previous study showed similar results [24].…”

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Analgesic and acute inflammation properties of the aqueous extract of dried leaves of Paullinia Pinnata (Sapindaceae) Linn

Patience¹,

Brice²,

Julia³

et al. 2017

ijpm

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“…Thus, they may be acting either at the peripheral or the central level, or both. 28 The neurogenic inflammation induced by xylene is related to cellular mechanisms involved in the release of pro-inflammatory substances by sensory a Groups Dose mg/kg neurons and is useful for the evaluation of topical antiinflammatory steroids and nonsteroidal antiphlogistic agents, especially those inhibiting phospholipase A2. 29 Application of xylene causes vasodilatation, increases vascular permeability and plasma extravasations leading to swelling of the ear.…”

Section: Discussionmentioning

confidence: 99%

Atividade antinociceptiva e anti-inflamatória do extrato hexânico de "Echinodorus macrophyllus" (Kunth) Micheli em camundongos

Fernandes

Martins

Medeiros

et al. 2019

BJHBS

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Introduction: Echinodorus macrophyllus (Kunth) Micheli,Alismataceae, commonly known as “chapéu de couro”, isused in the treatment of various inflammatory conditions.The aim of this study was to evaluate the antinociceptiveand anti-inflammatory neurogenic potential and perform thephytochemical analysis of its hexanic extract (HEEm). Materialand methods: The HEEm was obtained by maceration ofdried leaves with hexane (100 g d.w./2 L). Its composition wasdetermined by GC-MS (DB1 column) by comparison of retentionindices in the database and literature. The antinociceptivepotential was evaluated in SW or DBA/1 male mice usingchemical (acetic acid and formalin), thermal (tail immersionand hot plate tests) and topical (xylene) nociception models,all approved by the Ethics Committee (CEA-IBRAG). Results:HEEM presented antinociceptive activity in the model of:acetic acid-induced writhing (52%; 25mg/kg); tail immersion(60 and 90 minutes; 50 mg/kg); hot-plate in 60 minutes (25and 100mg/kg) and 120 minutes (25mg/kg); formalin tests, atthe neurogenic (63.4%, 100mg/kg), and inflammatory (50%;50 and 100mg/kg) phases; and in neurogenic inflammationinduced by xylene (88.3%; 100mg/kg). These activities seem tobe related to the terpene and fatty acid derivatives evidencedby GC-MS. Discussion: HEEm presented antinociceptive, aswell as anti-inflammatory, activity by central and peripheralmechanisms, It consists of terpenic and fatty acid derivatives,described in the literature as antioxidants, anti-inflammatory,and antinociceptives. Conclusions: HEEm showed antinociceptiveactivity in all models, which can be related to thepresence of terpenic and fatty acid derivatives.Keywords: Echinodorus macrophyllus; Nociception;Neurogenic inflammation; Phytochemistry.

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“…The injection of formalin produces two distinct phases: the first phase called neurogenic nociception is produced by the direct activation of the nociceptive fibers, which release substance P, glutamate and bradykinin; the late phase is mediated by the release of inflammatory mediators such as nitric oxide, excitatory amino acids (aspartate and glutamate), cyclins, prostaglandins (PGE2) and leukotrienes. 35 Tail -flick test is predominantly based on the spinal reflex and is considered selective for centrally acting analgesic compounds. Tail immersion test evaluates peripheral and central activity, and is also considered a model of chronic pain.…”

Section: Experimental Models and Painmentioning

confidence: 99%

Potential Activity of Medicinal Plants as Pain Modulators: A Review

Silva-Correa¹,

Campos-Reyna²,

Torre³

et al. 2021

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This review aims to demonstrate the relevance that medicinal plants and their promising results have in prevention and treatment of pain. The neurophysiological bases of pain have been analyzed and the potential mechanisms of action have been proposed, it has also been determined that the main experimental models used for the evaluation of the analgesic potential are: acetic acid-induced writhing test, formalin test, hot-plate test, capsaicin-induced nociception, cinnamaldehyde-induced nociception, glutamate-induced nociception, tail-flick test and tail immersion test. There are countless medicinal plants with potential analgesic activity, in some of them main responsible compounds for the activity are flavonoids (vitexin, quercetin, naringenin, astragalin, eupatilin), alkaloids (scotanamine B, bullatine A, S-(+)dicentrine, stephalagine, lappaconitine), terpenoids (p-cymene, thymol, menthol, citronellol, myrcene, carvacrol, linalool) and saponins (siolmatroside I, cayaponoside D, cayaponoside B4, cayaponoside A1); however, all studies have only been carried out up to pre-clinical stages. Therefore, it is recommended to carry out kinetic studies of the most remarkable natural compounds, evaluate mixtures of active compounds for diminishing doses to avoide possible side effects, and continue with clinical studies of medicinal plants whose safety has already been reported.

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Antinociceptive properties of the aqueous and methanol extracts of the stem bark of Petersianthus macrocarpus (P. Beauv.) Liben (Lecythidaceae) in mice

Cited by 15 publications

References 21 publications

Analgesic and acute inflammation properties of the aqueous extract of dried leaves of <em>Paullinia Pinnata</em> (Sapindaceae) Linn

Analgesic and acute inflammation properties of the aqueous extract of dried leaves of <em>Paullinia Pinnata</em> (Sapindaceae) Linn

Atividade antinociceptiva e anti-inflamatória do extrato hexânico de "Echinodorus macrophyllus" (Kunth) Micheli em camundongos

Potential Activity of Medicinal Plants as Pain Modulators: A Review

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