Antinociceptive properties of oxymorphazole in the mouse

Wu, Hsiang‐En; Sun, Han-Sen; Darpolar, Moses; Dunn, William J.; Tseng, Leon F.

doi:10.1016/s0014-2999(03)01912-5

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…Doses were selected based on previous studies [11][12][13] and our preliminary experiments. All of the OR antagonists were dissolved in saline, and the volume of each injection was 10 l. These antagonists were directly delivered by intrathecal injection on L4-5 segments of spinal cord in rats.…”

Section: Drug Administrationmentioning

confidence: 99%

Contralateral electroacupuncture pretreatment suppresses carrageenan-induced inflammatory pain via the opioid-mu receptor

et al. 2010

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Acupuncture has been used to treat various clinical diseases in Eastern medicine. To investigate the analgesic effect of electroacupuncture (EA) pretreatment on carrageenan-induced inflammatory pain, we studied on the effect of EA parameters on an animal model of acute arthritic pain. Pretreatment with 1 mA, 10 Hz EA prior to carrageenan injection under halothane anesthesia suppressed carrageenan-induced pain. Interestingly, EA stimulation of the 'Zu-San-Li' (ST36) acupuncture point (1 mA, 10 Hz) contralateral to the site of the carrageenan injection in the rat synovial cavity produced significantly greater improvement of the weight-bearing force compared with EA stimulation of the 'San-Yin-Jiao' acupuncture point. To determine how ST36 EA treatment suppresses carrageenan-induced inflammatory pain, we examined the effect of a mu opioid receptor antagonist on ST36 EA-induced analgesia. The selective antagonist of the mu opioid receptor (OR) significantly suppressed contralateral ST36 EA-induced analgesia against carrageenan-induced inflammation. These results suggested that the analgesic effect mediated by the mu OR during low-frequency contralateral EA pretreatment has an anti-nociceptive action against inflammatory pain and that it may provide a potential strategy to treat inflammatory arthritic pain.

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Section: Drug Administrationmentioning

confidence: 99%