Abstract:Antinociceptive Properties of Chloromaleinimides and Their Sulfonyl Derivatives. -A variety of new chloromaleimides [cf. (V), (IXa)] and corresponding sulfonyl derivatives [cf. (VIII), (IXb,c)] are synthesized and evaluated for their antinociceptive activities. Some of them, when intraperitoneally injected, prove to be potent and dose-related antinociceptives, being several times more active than many known reference drugs. -(WALTER, M. E.; MORA, C.; MUNDSTOCK, K.; DE SOUZA, M. M.; DE OLIVEIRA PINHEIRO, A.; YU… Show more
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