Antinociceptive peripheral effect of Achillea millefolium L. and Artemisia vulgaris L.: both plants known popularly by brand names of analgesic drugs

Abstract

The hydroalcohol extracts of Achillea millefolium L. (AM) and Artemisia vulgaris L. (AV), both belonging to the Asteraceae family, were evaluated by the hot plate, writhing, formalin and intestinal transit tests in an attempt to confirm their folk use as analgesic, antiinflammatory and antispasmodic agents. AM 500 and 1000 mg/kg significantly inhibited abdominal contortions by 65% and 23%, respectively, whereas AV 500 and 1000 mg/kg inhibited them by 48% and 59%, respectively. None of the extracts produced differences in the intestinal transit in mice, nor in the response time in the hot plate or in the immediate or late responses in the formalin test. In HPLC/DAD analyses 'fingerprint', monitored at 360 and 270 nm, both hydroalcohol extracts showed the same flavonoid glycoside as a principal constituent, which was identified as rutin. A high content of caffeic acid derivatives were also found in both extracts. The main differences were observed at 240 nm: AM had a higher content of rutin, while in AV the hydroxybenzoic acid derivative was the major component.

Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review

“…Sesquiterpene lactones isolated from A. setacea (Zitterleglseer et al, 1991) and a germacrane derivative isolated from A. pannonica Scheele (Sosa et al, 2001) showed good anti-inflammatory activity. In some of the other similar reports, the anti-nflammatory (Saratikov et al, 1986;Karabay-Yavasoglu et al, 2007;Kupeli et al, 2007) and anti-nociceptive (Karabay-Yavasoglu et al, 2007;Kupeli et al, 2007;Pires et al, 2009;Radulovic et al, 2012;Radulovic et al, 2015) properties have also been evaluated.…”

Anglo-Saxon pharmacopoeia revisited: a potential treasure in drug discovery

“…In Germany yarrow flower is licensed as a standard medicinal tea and in the USA it is used as a diaphoretic or febrifuge component of traditional cold and flu/fever compounds marketed as dietary supplements [20]. Recent pharmacological studies of plant extracts from all parts of A. millefolium have demonstrated anti-inflammatory properties [21,22], antileishmanial activity of oil from leaves and flowers [23] and in vivo antinociceptive effects [24]. Known A. millefolium constituents include matricin and other proazulenic sesquiterpene lactones known to yield chamazulene carboxylic acid (Fig.…”

Évaluation de l'activité antivirale de cinq espèces végétales de la forêt boréale contre les virus influenza de type A et l'herpès simplex de type 1 /

“…Une description sommaire des plantes est présentée ici suivi d'une photo de chacune de ces plantes (voir figure 5) (Marie-Victorin, 1995 (Candan et al, 2003;Kintzios et al), anti-inflammatoire (Benedek and Kopp, 2007;Goldberg et al, 1969), antinociceptive (Pires et al, 2009) et antifertilité (Takzare et al, 2010). De plus, plusieurs groupes de recherche ont rapporté qu'Achillea millefolium possède des propriétés : protectrice contre les lésions gastriques chroniques (Cavalcanti et al, 2006) 5 antiulcérogène (Potrich et al, 2010), hépatoprotectrice (Yaeesh et al, 2006), cholérétique (Benedek et al, 2006) et antidiarrhéique (Babaei et al, 2007).…”