Antinociceptive, neurobehavioral and antioxidant effects of Eupatorium triplinerve Vahl on rats

Melo, Ademar Soares; Monteiro, Marta Chagas; Silva, Josiane Batista da; Oliveira, Fábio Rodrigues de; Vieira, José Luís Fernandes; Andrade, Milene Aparecida; Baetas, Ana Cristina; Sakai, Joni Tetsuo; Ferreira, Fabrício Alexopulos; Sousa, Pergentino José da Cunha; Maia, Cristiane do Socorro Ferraz

doi:10.1016/j.jep.2013.03.002

Cited by 27 publications

(22 citation statements)

References 35 publications

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“…In this model of inflammatory pain, occurs the release of several pro-inflammatory mediators such as prostaglandins, bradykinin, substance P, and cytokines as interleukins (IL)-1, -8 and tumor necrosis factor (Rossato et al, 2014) and it is sensitive to non-steroidal anti-inflammatory drugs (NSAIDs) such as sodium diclofenac (Melo et al, 2013). Moreover, this nociceptive test is used to detect antinociceptive activity of drugs acting on the peripheral, spinal and supraspinal levels (Hardy et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…In the first phase (0-5 min) of formalin test occurs activation of nociceptive neurons (neurogenic pain), while the second phase (15-30 min) is consequence of the inflammatory response to tissue injury (inflammatory pain) leading to the release of histamine, serotonin, prostaglandins and excitatory amino acids (Melo et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Medicinal plants have been used almost in all cultures as sources of medicine to treat, cure or prevent diseases (Melo et al, 2013;Silva et al, 2012). Most of these plants have been evaluated using experimental animal models (Al-Sayed and El-Naga, 2015;Silva et al, 2013) as well as in humans (Dapas et al, 2014) in order to confirm their activities.…”

Section: Introductionmentioning

confidence: 99%

“…Literature data shows that several plant extracts are commonly used for the treatment of painful and inflammatory conditions (Melo et al, 2013;Silva et al, 2012Silva et al, , 2013. Pain is one of the most prevalent conditions that limits productivity and reduces the quality of patient's life.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Tabernaemontana catharinensis ethyl acetate fraction presents antinociceptive activity without causing toxicological effects in mice

Brum

Moreira

Silva

et al. 2016

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tabernaemontana catharinensis ethyl acetate fraction presents antinociceptive activity without causing toxicological effects in mice

Brum

Moreira

Silva

et al. 2016

Journal of Ethnopharmacology

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“…] are used in folk medicine as a heart stimulant, laxative and anticoagulant (Gupta et al, 2002). In rainforests of South America, its leaves are used in decoctions, infusions, tea and baths as tonic, stimulant, sedative, febrifuge and anti-inflammatory, especially in Brazilian folk medicine (Melo et al, 2013). The first preliminary studies of this species were performed by Oswaldo Gonçalves de Lima, then director B.…”

Section: Eupatorium Ayapana Ventmentioning

confidence: 99%

The genus Eupatorium L. (Asteraceae): A review of their antimicrobial activity

Sobrinho¹,

Selene²,

Elnatan³

et al. 2017

J. Med. Plants Res.

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In recent years, the number of infectious diseases linked to the occurrence of bacterial and fungal resistance has increased, leading to extensive search for new drugs to treat these infections. Species of the Asteraceae family and the genus Eupatorium, have high biological potential and are used in folk medicine to treat various diseases. This review article presents the main phytochemical and biological characteristics of the Asteraceae family and the genus Eupatorium s.l., whose antimicrobial activity is promising, especially antibacterial and antifungal activity. The current review was achieved using an organized search of the scientific data published on antimicrobial activity and phytochemical of the species of the genus Eupatorium using various databases, including PubMed, ScienceDirect, Scopus, Scielo, SciFinder and Google Scholar. The species of Eupatorium are rich in terpenes, phytosterols and sesquiterpene lactones, the latter being chemotaxonomic markers of the group, with broad anticancer, antiplasmodial and antimicrobial activity, making them promising for the development of new drugs. Various species of Eupatorium seems to hold great potential for in-depth investigation for antimicrobial activities. Many species have broad folk use, with scientific confirmation of its antimicrobial properties making these plants potential sources of safer and more effective treatments.

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A reversed‐phase ultra‐fast liquid chromatography–photodiode array detector (RP‐UFLC‐PDA) method for simultaneous estimation of ayapanin and umbelliferone in Ayapana triplinervis Vahl

Biswas

Kar

Chanda

et al. 2022

Biomedical Chromatography

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A rapid validated ultra‐fast liquid chromatography–photodiode array detector (UFLC‐PDA) method was developed to identify and quantify ayapanin (AY) and umbelliferone (UM) simultaneously in Ayapana triplinervis Vahl methanolic extract. The method was validated for linearity, limit of detection (LOD; 3:1σ/S), limit of quantification (LOQ; 10:1σ/S), precision, accuracy, specificity and robustness. The response was linear with a good correlation between concentration and mean peak area through a correlation coefficient of 0.9996, y = 7025.7x – 2269.8 and 0.9997, y = y = 16,262x – 946 with LOD of 6.256 ± 0.52 and 3.325 ± 0.36, and LOQ of 18.838 ± 0.18 and 8.870 ± 0.85 for AY (0.67% w/w) and UM (0.18% w/w), respectively. The relative standard deviation (%) of precision and recovery of AY and UM was <2.0%. The proposed method was simple, accurate, specific, precise and reproducible.

show abstract

Antinociceptive, neurobehavioral and antioxidant effects of Eupatorium triplinerve Vahl on rats

Cited by 27 publications

References 35 publications

Tabernaemontana catharinensis ethyl acetate fraction presents antinociceptive activity without causing toxicological effects in mice

Tabernaemontana catharinensis ethyl acetate fraction presents antinociceptive activity without causing toxicological effects in mice

The genus Eupatorium L. (Asteraceae): A review of their antimicrobial activity

A reversed‐phase ultra‐fast liquid chromatography–photodiode array detector (RP‐UFLC‐PDA) method for simultaneous estimation of ayapanin and umbelliferone in Ayapana triplinervis Vahl

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