Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice

Wandji, Bibiane Aimée; Bomba, Francis Desire Tatsinkou; Awouafack, Maurice D.; Nkeng-Efouet, Pepin Alango; Kim, Albert; Nguelefack, Télesphore Benoît

doi:10.1016/j.jep.2016.04.041

Cited by 20 publications

(7 citation statements)

References 22 publications

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“…3-fold more (p < 0.05) total phenolics than the QLD samples ( Table 4). The results of the present study are similar to the reported TPC in leaves and twigs of other species belonging to the Pittosporaceae family, ranging from 2600 to 4090 mg GAE/100 g DW [42][43][44][45]. However, compared to green tea leaf powder, a popular source of polyphenols, the TPC in the studied P. angustifolium samples was lower (730-4075 mg GAE/100 g DW vs. 6500-10,600 mg/100 g DW [46]).…”

Section: Total Phenolic Content (Tpc)supporting

confidence: 90%

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Nutritional Value and Antimicrobial Activity of Pittosporum angustifolium (Gumby Gumby), an Australian Indigenous Plant

Phan

Chaliha

Hong

et al. 2020

Foods

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The indigenous endemic plant P. angustifolium has received attention for nutraceutical and therapeutic applications in Australia. This study investigates for the first time the nutritional value (macro- and micronutrients, minerals, trace elements, polyphenols, carotenoids, saponins and antioxidant capacity) and antimicrobial activity of different botanical parts of P. angustifolium, either collected from the wild or cultivated. Different botanical tissues, geographic location and growing condition (wild vs. cultivated) showed significant (p < 0.05) effects on the tested bioactive compounds, with the leaves having significantly (p < 0.05) higher levels than the stems. Saponins and polyphenols could be identified as the main bioactive compounds in the leaves with up to 4% per dry weight. The extracts of P. angustifolium leaves and stems showed strong antioxidant and antimicrobial activities, especially against Candida albicans. These activities correlated (R2 = 0.64–0.92; p < 0.05) with the levels of polyphenols and saponins, indicating their biologic potential. Findings from this study may provide information for future applications of P. angustifolium in the functional ingredient or nutraceutical industry.

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Section: Total Phenolic Content (Tpc)supporting

confidence: 90%

Section: Total Phenolic Content (Tpc)supporting

confidence: 90%

Nutritional Value and Antimicrobial Activity of Pittosporum angustifolium (Gumby Gumby), an Australian Indigenous Plant

Phan

Chaliha

Hong

et al. 2020

Foods

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“…Several species of Pittosporum have been explored for phytochemical and pharmacological properties. Crude extracts and metabolites of plants belonging to this genus possess diverse biological activities, including antidiarrheal, antimicrobial, antimalarial, and anti-inflammatory functions. − The natural products isolated from Pittosporum include sesquiterpenoids, − triterpenoids, − neolignans and their glycosides, and carotenoids. − …”

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confidence: 99%

Structurally Diverse Sesquiterpenoid Glycoside Esters from Pittosporum qinlingense with Anti-neuroinflammatory Activity

et al. 2022

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Thirteen new sesquiterpenoid glycoside esters, including 11 aromadendrane-type compounds, pitqinlingosides A–K (1–11), one cadinane-type compound, pitqinlingoside L (12), and one eudesmane-type compound, pitqinlingoside M (13), together with seven known analogues (14–20) were isolated from the twigs, fruits, and leaves of Pittosporum qinlingense. Structures were elucidated by analysis of spectroscopic data, gas chromatography mass spectrometry (GC-MS), and chemical methods. The absolute configuration was confirmed by single-crystal X-ray crystallography analysis or electronic circular dichroism spectra. Unusual glycoside esters are characterized by the presence of polyacylated β-d-fucopyranosyl, β-d-glucopyranosyl, and β-d-xylopyranosyl units. Pitqinlingosides A (1), B (2), D (4), and F (6), pittosporanoside A1 acetate (14), and pittosporanoside A1 (16) showed significant nitric oxide production inhibition in lipopolysaccharide (LPS)-induced BV-2 microglial cells with IC50 values ranging from 0.95 to 24.12 μM. Structure–activity relationships of the isolated compounds are discussed.

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“…Muscarinic receptors, when activated, promote spinal cord analgesia by promoting the release of inhibitors from excitatory transmitters. [25] Based on these findings, we believe that the EAF comprises substances that activate opioid and cholinergic systems to promote its analgesic effect.…”

Section: Resultsmentioning

confidence: 90%

Flavonoid‐Rich Fraction from Croton blanchetianus (Euphorbiaceae) Leaves Exerts Peripheral and Central Analgesic Effects by Acting via the Opioid and Cholinergic Systems

Oliveira

Widmer

Nascimento

et al. 2022

Chemistry & Biodiversity

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The ethanolic extract from Croton blanchetianus leaves has been shown to have antinociceptive activity in mice. Here, we investigated the antinociceptive activity of an ethyl acetate fraction (EAF) from this extract in mice and the possible pathways involved in the analgesic effect. Adverse effects on behavior and motor coordination were also evaluated. The EAF was characterized by liquid chromatography coupled with mass spectrometry and evaluated (12.5, 25, and 50 mg/kg per os) in the acetic acid-induced abdominal writhing, formalin, hot plate, and tail immersion assays. Naloxone, atropine, glibenclamide, prazosin, or yohimbine was pre-administered to mice to investigate the involved pathways in the formalin test. The open-field, rotarod, and elevated plus-maze tests were used to assess behavior and locomotion. The main components of the EAF were quercetin-3-O-(2-rhamnosyl) rutinoside, hyperoside, quercetin rutinoside pentoside, and quercetin hexoside deoxyhexoside. EAF showed antinociceptive effects in all models and was effective against both neurogenic and inflammatory pain. The reversion of the effects in the formalin test by naloxone and atropine revealed that the EAF acted via the opioid and cholinergic systems. In the open-field test, the behavior of the animals treated with the EAF was like that of control, except at the highest dose, when hypnosis, eyelid ptosis, decreased walking, hygiene, and rearing behaviors were observed. No muscle relaxant effect was observed, but an anxiogenic effect was observed at all doses. This study provides new scientific evidence on the pharmacological properties of C. blanchetianus leaves and their potential for the development of phytomedicines with analgesic properties.

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Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice

Cited by 20 publications

References 22 publications

Nutritional Value and Antimicrobial Activity of Pittosporum angustifolium (Gumby Gumby), an Australian Indigenous Plant

Nutritional Value and Antimicrobial Activity of Pittosporum angustifolium (Gumby Gumby), an Australian Indigenous Plant

Structurally Diverse Sesquiterpenoid Glycoside Esters from Pittosporum qinlingense with Anti-neuroinflammatory Activity

Flavonoid‐Rich Fraction from Croton blanchetianus (Euphorbiaceae) Leaves Exerts Peripheral and Central Analgesic Effects by Acting via the Opioid and Cholinergic Systems

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