Antinociceptive effects of saccharose and aqueous extract of Cordyline dracaenoides kunth (uvarana) in experimental models after induction of hyperalgesia using capsaicin

Abstract

OBJECTIVE: There is evidence that sweet substances such as saccharose can enhance the analgesic properties of endogenous opioids, leading to pain relief; it is also known that Cordyline dracaenoides Kunth, commonly known as uvarana, is used in folk medicine as an anti-inflammatory and analgesic agent. The aim of the present study was to compare the antinociceptive effects of uvarana aqueous extracts vs. saccharose in rats. METHOD: Twenty-four Wistar rats were used, divided into two groups of twelve, namely a uvarana and a saccharose group. Capsaicin was used to induce hyperalgesia and the nociceptive threshold was assessed every five minutes for a total of 50 minutes Baseline values were obtained and this was followed by administration of uvarana or saccharose at threedifferent concentrations (100, 250 and 300 g/L) The nociceptive threshold was assessed using the tail flick test. RESULT: In comparison to baseline values, uvarana and saccharose provoked significant and comparable antinociceptive effects at concentrations of 250 g/L and 300 g/L, respectively. CONCLUSION: Both substances caused similar antinociceptive effects in comparison to baseline values.

Controlled-release Fertilizer in Cordyline spectabilis Seedlings Production, a Potential Species of the Asparagaceae Family

“…The palm heart canning has a high protein content and its flour has a high fiber content, both of which have a low caloric value (Helm et al, 2011). The species biomedical applications are promising as an anti-inflammatory, analgesic, rheumatism treatment, and associated diseases (Ribeiro et al, 2014). Another use of Cordyline spectabilis is in urban landscaping (Viezzer et al, 2018), which justifies its cultivation on a commercial scale.…”