Antinociceptive effects of low-intensity extrahigh-frequency electromagnetic radiation

Abstract

We studied the effect of low-intensity extrahigh-frequency (EHF) electromagnetic radiation (EMR) on changes of behavior phenomena in rats observed under conditions of experimentally induced tonic somatic, visceral, and acute thermal pain. Preliminary irradiation of the animals with EHF EMR was found to exert clear antinociceptive effects. Decreases in the intensity of pain reactions were observed under conditions of both single and repeated irradiation sessions.

Roles of different neurochemical systems in mechanisms underlying the antinociceptive effect of extrahigh-frequency electromagnetic radiation

“…In our earlier study [9], we found that low-intensity EHF EMR also possesses a clearly pronounced antinociceptive action in pain stresses of different etiologies (experimentally induced tonic, visceral, and acute thermal pain). However, the mechanisms underlying this phenomenon have been interpreted only hypothetically.…”

“…Influences of this factor are widely used in medical practice for the treatment of various diseases [1][2][3][4]. It was demonstrated that the action of EHF EMR provides anti-stress, immunomodulating, anti-oxidant, anti-inflammatory, radioprotective, and a number of other effects; it also synchronizes rhythmic biological processes [5][6][7][8].…”

Antiepileptic effects of short-wave radiation in hypogeomagnetic conditions

“…Considering possible mechanisms, which are in charge for EMR SHF antiepileptic effects, it should be mentioned that involvement of serotoninergic and histaminergic receptor-depended mechanisms in the development of antinociceptive effects of EMR EHF has been established [1,5]. Besides, transcutaneus action of EMR EHF activated endogenous opioid system and precipitated analgesic action [2].…”

“…Taking into consideration the experimental conditions, absorbed dosage of emitted energy did not exceed 0,05-0,1 J per animal, when 15,0 min exposition of EMR was performed. Hence, EMR did not induce thermal effect, which is quite characteristic for an action of such type of irradiation [1,5,6]. Hence, under such conditions the absence of thermal effects of such influence was expected [18].…”

“…The anti-epileptic effect may be based on the EHF radiation ability to increase the tone of serotonergic, opioid, noradregenic and neuromodulator systems [1,4], as well as histaminergic central mechanisms [5], the activation of which leads to suppression of convulsive activity of the brain [3,7,10]. EHF EMR provides significant anti-inflammatory effect, which manifests both in local [5] and systemic inflammation process [8].…”