Antinociceptive effects of epidural administration of hydromorphone in conscious cats

Ambros, Barbara; Steagall, Paulo V.; Mantovani, Fernanda; Gilbert, Peter; Duke‐Novakovski, Tanya

doi:10.2460/ajvr.70.10.1187

Cited by 10 publications

(8 citation statements)

References 26 publications

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“…114 The epidural administration of 0.05 mg/kg hydromorphone caused thermal and some mechanical antinociception without hyperthermia. 115 SC administration of hydromorphone provides a slower onset of peak effect, shorter duration of antinociception and more undesirable side effects (emesis and salivation) than IV or IM administration, so this route of administration is not recommended. 116 Hydromorphone increases skin temperature in cats; patients should be monitored closely for postanaesthetic hyperthermia.…”

Section: Hydromorphonementioning

confidence: 99%

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Practical use of opioids in cats: a state-of-the-art, evidence-based review

Bortolami

Love

2015

Journal of Feline Medicine and Surgery

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Section: Hydromorphonementioning

confidence: 99%

“…114 The epidural administration of 0.05 mg/kg hydromorphone caused thermal and some mechanical antinociception without hyperthermia. 115…”

Section: Hydromorphonementioning

confidence: 99%

Practical use of opioids in cats: a state-of-the-art, evidence-based review

Bortolami

Love

2015

Journal of Feline Medicine and Surgery

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“…Although a control treatment without administration of analgesics was not used in this study, TT and MT did not increase or decrease over time after epidural administration of saline in two another studies using similar cats (Millette et al. , 2008; Ambros et al. , 2009).…”

Section: Discussionmentioning

confidence: 84%

Antinociceptive effects of epidural buprenorphine or medetomidine, or the combination, in conscious cats

Steagall

Millette

Mantovani

et al. 2009

Vet Pharm & Therapeutics

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The aim of this study was to compare the antinociceptive effects of epidural buprenorphine (EB), epidural medetomidine (EM) or epidural buprenorphine-medetomidine (EBM). Eight cats were studied. Thermal thresholds (TT) were measured by increasing the temperature of a probe placed on the thorax. Mechanical thresholds (MT) were measured through inflation of a modified blood pressure bladder to the cat's forelimb. After baseline measurements, EB (0.02 mg/kg), EM (0.01 mg/kg) or half of the doses of each drug (EBM) were administered. Data were analysed using anova (P < 0.05) and 95% confidence interval (CI). TT increased from 30 min to 1 h after EB and at 45 min after EM. MT increased from 45 min to 2 h after EB, from 15 min to 1 h after EM and at 30, 45 min and at 2 h after EBM. MT were significantly lower after EB than EM at 30 min. TT were above the upper 95%CI from 15 min to 24 h after EB, from 15 min to 4 h after EM and from 15 min to 8 h after EBM. MT were above the upper 95%CI from 15 min to 5 h, and at 8, 12 and 24 h after EB, from 15 min to 6 h after EM and from 15 min to 6 h and at 12 and 24 h after EBM. All treatments had similar onset. Overall, EB presented longer period of action than EBM and EM. The same magnitude of analgesia was achieved, but with fewer side effects when EBM was compared with EM.

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“…Thermal provocation pain tools, consisting of two subtypes (thermal threshold [TT] test 75,81,88 and radiant emitter mat test 63,80,84 ). These provide a unidimensional measure of the sensory reaction, looking at the temperature necessary to result in withdrawal.…”

Section: Resultsmentioning

confidence: 99%

“…Multidimensional assessment of both the sensory and affective domains of pain may be undertaken with these scales. 107,111,113 ArƟcles idenƟfied through scienƟf ic database search (n = 300) 4 Thermal provocation pain tools, consisting of two subtypes (thermal threshold [TT] test 75,81,88 and radiant emitter mat test 63,80,84 ). These provide a unidimensional measure of the sensory reaction, looking at the temperature necessary to result in withdrawal.…”

Section: Time Of Presenting Signsmentioning

confidence: 99%