Antinociceptive effects of calcitonin gene-related peptide injected into periaqueductal grey of rats with mononeuropathy

Xu, Shi-Lian; Lundeberg, Thomas; Yu, Long-Chuan

doi:10.1016/s0006-8993(99)02407-5

Cited by 18 publications

(15 citation statements)

References 10 publications

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“…The CGRP-induced analgesia is effectively blocked by intra-PAG administration of CGRP8-37, indicating that CGRP receptor 1 is involved in the CGRP-induced antinociception in PAG . Similar results are obtained in rats with mononeuropathy (Xu et al, 2000). The results strongly suggest that CGRP and CGRP8-37 have different effects on the transmission and modulation of pain information in the brain as opposed to that in the spinal cord.…”

Section: Roles Of Cgrp and Cgrp Receptors In Pain Modulation At Supersupporting

confidence: 82%

“…Intrathecal CGRP Mechanical nociception (Oku et al, 1987;Sun et al, 2004) No effects (Jolicoeur et al, 1992;Yu et al, 1994) CGRP8-37 Antinociceptive effects in normal animal (Yu et al, 1994(Yu et al, , 1995 Antinociceptive effects in inflammation pain animal (Salmon et al, 2001;Yu et al, 1996a) Antinociceptive effects in neuropathical pain animal (Yu et al, 1996b) Dorsal horn neurons CGRP Excitatory effects on neuronal activity (Leem et al, 2001;Neugebauer et al, 1996;Sun et al, 2004;Yu et al, 2002) CGRP8-37 Inhibitory effects on neuronal activity (Neugebauer et al, 1996;Yan and Yu, 2004;Yu et al, 1999) Brain PAG CGRP Antinociceptive effects in normal animal Antinociceptive effects in neuropathical pain animal (Xu et al, 2000) CGRP8-37 No effects alone, block CGRP-induced antinociception in normal animal No effects alone, block CGRP-induced antinociception in neuropathical pain animal (Xu et al, 2000) NRM CGRP Antinociceptive effects in normal animal (Huang et al, 2000) CGRP8-37…”

Section: Spinal Cordmentioning

confidence: 99%

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Roles of calcitonin gene-related peptide and its receptors in pain-related behavioral responses in the central nervous system

Hou

et al. 2009

Neuroscience & Biobehavioral Reviews

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Section: Roles Of Cgrp and Cgrp Receptors In Pain Modulation At Supersupporting

confidence: 82%

Section: Spinal Cordmentioning

confidence: 99%

Roles of calcitonin gene-related peptide and its receptors in pain-related behavioral responses in the central nervous system

Hou

et al. 2009

Neuroscience & Biobehavioral Reviews

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“…43 Microinjection of CGRP into the PAG blocked nociception in normal and nerve-injured rats, and this effect was reversed by CGRP (8-37) . 195,201 The CeA, which also contributes to the regulation of pain, was found to contain CGRP receptors as well as nerve fibers containing CGRP. 196 Microinjection of CGRP into the CeA produced dose-dependent antinociception in rats blocked by intra-CeA CGRP (8-37) and systemic naloxone.…”

Section: Supraspinal Effects Of Calcitonin Gene–related Peptidementioning

confidence: 99%

“…196 Retrograde fluorescent tracing studies along with immunohistochemistry indicated that CGRP released within the CeA activated enkephalinergic projections to the PAG, thus producing an antinociceptive effect. 195,196 In a study where the subcutaneous injection of 10 mg/kg of nitroglycerin to rats was proposed to act as an experimental migraine model, this treatment resulted in an increase in mRNA and protein levels of CGRP in the PAG. 198 This increase was blocked by pretreatment with rizatriptan.…”

Section: Supraspinal Effects Of Calcitonin Gene–related Peptidementioning

confidence: 99%

The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

Iyengar

Ossipov²,

Johnson

2017

Pain

449

364

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Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene–related peptide was found to play important roles in cardiovascular, digestive, and sensory functions. Although the vasodilatory properties of CGRP are well documented, its somatosensory function regarding modulation of neuronal sensitization and of enhanced pain has received considerable attention recently. Growing evidence indicates that CGRP plays a key role in the development of peripheral sensitization and the associated enhanced pain. Calcitonin gene–related peptide is implicated in the development of neurogenic inflammation and it is upregulated in conditions of inflammatory and neuropathic pain. It is most likely that CGRP facilitates nociceptive transmission and contributes to the development and maintenance of a sensitized, hyperresponsive state not only of the primary afferent sensory neurons but also of the second-order pain transmission neurons within the central nervous system, thus contributing to central sensitization as well. The maintenance of a sensitized neuronal condition is believed to be an important factor underlying migraine. Recent successful clinical studies have shown that blocking the function of CGRP can alleviate migraine. However, the mechanisms through which CGRP may contribute to migraine are still not fully understood. We reviewed the role of CGRP in primary afferents, the dorsal root ganglion, and in the trigeminal system as well as its role in peripheral and central sensitization and its potential contribution to pain processing and to migraine.

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“…It is known that CGRP plays an important role in nociceptive modulation in the central nervous system (Yu et al, 1994(Yu et al, , 1996avan Rossum et al, 1997;Xu et al, 2000;Li et al, 2001). Dense distributions of CGRP receptors were found in the superficial dorsal horn, the major terminal site of nociceptive primary afferents (Sotgiu and Biella, 1998;Ye et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Involvement of opioid receptors in the CGRP8‐37‐induced inhibition of the activity of wide‐dynamic‐range neurons in the spinal dorsal horn of rats

Yan

2004

J of Neuroscience Research

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The present study was performed to explore the involvement of opioid receptors in the calcitonin gene-related peptide 8-37 (CGRP8-37, an antagonist of CGRP receptor)-induced inhibition of the activity of wide-dynamic-range (WDR) neurons in the spinal dorsal horn of rats. Extracellular recording was performed with a multibarrelled glass micropipette, and the chemicals were delivered by micro-iontophoresis. The discharge frequency of WDR neurons was evoked by subcutaneous electrical stimulation applied to the ipsilateral hindpaw. Iontophoretic application of CGRP8-37 by an ejection current of 160 nA induced significant inhibition of the discharge frequency of WDR neurons. The inhibitory effect of CGRP8-37 on the activity of WDR neurons was attenuated by later iontophoretic application of the opioid antagonist naloxone. Furthermore, the effect of CGRP8-37 was attenuated by either iontophoretic application of the kappa-receptor antagonist nor-binaltorphimine (nor-BNI) or the mu-receptor antagonist beta-funaltrexamine (beta-FNA) but not by the delta-receptor antagonist naltrindole. The results indicate that kappa- and mu-opioid receptors on the membrane of WDR neurons are involved in the modulation of CGRP8-37-induced antinociception in dorsal horn of the spinal cord in rats.

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Antinociceptive effects of calcitonin gene-related peptide injected into periaqueductal grey of rats with mononeuropathy

Cited by 18 publications

References 10 publications

Roles of calcitonin gene-related peptide and its receptors in pain-related behavioral responses in the central nervous system

Roles of calcitonin gene-related peptide and its receptors in pain-related behavioral responses in the central nervous system

The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

Involvement of opioid receptors in the CGRP8‐37‐induced inhibition of the activity of wide‐dynamic‐range neurons in the spinal dorsal horn of rats

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