“…This unique pharmacophore can participate in several interactions with the proposed targets through both hydrogen-bond acceptor and donor of amino-acid residues of enzyme binding site. Acylhydrazone exhibited a wide range of pharmacological potencies as antimicrobial [ 35 ], anticancer [ 36 ], analgesic [ 37 ], and anti-inflammatory( 38 ) agents. Also, the potencies of acylhydrazone derivatives as tyrosinase [ 39 , 40 ], acetylcholinesterase [ 41 ], BACE1 [ 42 ], and α-glucosidase [ 43 ] inhibitors were reported.…”