Antinociceptive Effect of the Monoterpene R-(+)-Limonene in Mice

Abstract

In the present study were studied the antinociceptives properties of monoterpene R-(؉) (1 mg/kg, s.c.). It was also demonstrated that R-(؉)-limonene (25, 50 mg/kg) neither significantly enhanced the pentobarbital-sleeping time nor impaired the motor performance in rota-rod test, indicating that the observed antinociception is unlikely to be due to sedation or motor abnormality. In conclusion it may be suggested that the R-(؉)-limonene presented antinociceptive activity and that, probably, this action can be related with peripheral analgesia, but, not with the stimulation of opioids receptors.-

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

“…Brazil not only has one of the world's highest levels of biodiversity but also it has a wealth of traditional knowledge accumulated by local people who have direct access to nature and to the products of biodiversity (Albuquerque et al, 2007). In this sense, information from Brazilian ethnic groups on traditional medicine have contributed to the discovery of pharmacological activities from several plant-derived agents, which have resulted in a signifi cant body of publications (Almeida et al, 2001;Sousa et al, 2004a;2005;De Sousa et al, 2006;Amaral et al, 2007;Silva et al, 2007;Volpato et al, 2008;Silva et al, 2009a;Silva et al 2009b;Morais at al., 2010). In spite of this, the current knowledge on the biodiversity of ecosystems as, for example, of the northeast region, is still very embryonic.…”

Investigation of the Central, Peripheral Analgesic and Antiinflammatory Activity of Kutajarishta, an Indian Ayurvedic formulation

“…To reinforce the above findings, we employed the formalin induced paw-licking test. This test is capable of discerning between nurogenic pain (early phase, acute, non-inflammatory and CNS modulated) and inflammatory (chronic and peripheral pain) [16] [17] [18] . The neurogenic pain (first phase) is caused by direct chemical stimulation of nociceptive afferent fibers (predominantly C fibers) which can be suppressed by opiate like morphine [19] .…”

“…The neurogenic pain (first phase) is caused by direct chemical stimulation of nociceptive afferent fibers (predominantly C fibers) which can be suppressed by opiate like morphine [19] . The inflammatory pain (second phase) is caused by the release of inflammatory mediators like histamine, prostaglandins, bradykinin, serotonin in the peripheral tissues [18] , and from functional changes in the spinal dorsal horn [20] . Our results showed that KTJ had no effect on neurogenic pain suppression (first phase) but had effective anti-nociceptive effect in the peripheral inflammatory (second phase) pain.…”

Preclinical evaluation of repeated dose toxicity and anxiolytic activity of monoterpene R - (+) limonene via inhalation

“…N. E. BROWN (Verbanaceae) (Vale et al, 2002), Artemisia dracunculus L. (Asteraceae) (Sayyah et al, 2004), and other aromatic plant species. They present antinociceptive activity when intraperitoneally administered (Do Amaral et al, 2007). Moreover, the action of this monoterpene as a modulator of oxidative stress, also with chemopreventive activity (Manuele et al, 2010) has been reported, reducing skin tumors in animals (Chaudhary et al, 2012).…”