Antinociceptive effect of the essential oil of tarragon (<i>Artemisia dracunculus</i>)

Maham, Masoud; Moslemzadeh, Hemmat; Jalilzadeh-Amin, Ghader

doi:10.3109/13880209.2013.824007

Cited by 28 publications

(12 citation statements)

References 32 publications

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“…Fructose is a greatly lipogenic carbohydrate that has thoughtful metabolic effects on the liver inducing de nova lipogenesis and glucogenesis [24]. Investigation established that demonstration of the extracts from two Artemisia species in mice could enhance insulin-responsive by altering the serine phosphorelation in insulin receptor and affecting on monocyte chemotactic protein-1 levels in visceral white Adipocyte Tissue [25]. High fructose utilization in modern diet is frequently connected with insulin resistance, and distressed glucose homeostasis [26].…”

Section: Discussionmentioning

confidence: 99%

Effects of Artemisia dracunculus Aqueous Extract on Blood Sugar, Serum Insulin, Triglyceride and Liver Enzymes in Fructose Drinking Water Male Rats

Shahraki

Mirshekari

Saberi

et al. 2017

Zahedan J Res Med Sci

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Section: Discussionmentioning

confidence: 99%

Effects of Artemisia dracunculus Aqueous Extract on Blood Sugar, Serum Insulin, Triglyceride and Liver Enzymes in Fructose Drinking Water Male Rats

Shahraki

Mirshekari

Saberi

et al. 2017

Zahedan J Res Med Sci

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“…The results in the present study indicated that Artemisia aqueous extract decreased the acute and chronic pain responses in FDWE group compared to FDW group. Maham et al in 2014 confirmed that essential oil of Artemisia dracunculus (EOAD) has peripheral and central antinociceptive effects in normal mice and it seems that a variety of mechanisms compared to opioid receptors are involved in the analgesic effect of EOAD [ 24 ]. Our results in this study showed that acute and chronic pain score in FDWE group is significantly lower than that of FDW group and it is confirmed by prior studies.…”

Section: Discussionmentioning

confidence: 99%

The Nociceptive and Anti-Inflammatory Effects ofArtemisia dracunculusL. Aqueous Extract on Fructose Fed Male Rats

Reza

Mirshekari

Saberi

2015

Evidence-Based Complementary and Alternative Medicine

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Aim & Objective. Artemisia dracunculus L. (Tarragon) species have been used as a traditional medicine. The present study was designed to evaluate the nociceptive and anti-inflammatory effects of A. dracunculus L. leaf aqueous extract on fructose drinking water (FDW) in male rats. Materials & Methods. Forty-eight Wistar-albino male rats weighing 200–250 g were divided into control (C), control extract (CE), FDW, and FDWE groups (n = 12). Group C did not receive any agents; Group CE did 100 mg/kg A. dracunculus L. aqueous extract on a daily basis for duration of four weeks. FDW Group received fructose drinking water (10%, weight/volume) but did not receive any agents during trial period. FDWE group received 100 mg/kg A. dracunculus L. aqueous extract during trial period. At the end of experiment, a biphasic pain response was induced following interplanetary injection of formalin (50 µL, 1%). Obtained data were analyzed using SPSS software version 17 and using ANOVA and Tukey post hoc tests. Results were expressed as mean ± SE. Statistical differences were considered significant at P < 0.05. Results. Our findings revealed that acute and chronic pain scores in FDW group are significantly higher than other ones and A. dracunculus L. aqueous extract causes significant decreasing of this parameter in FDWE group (P < 0.001). Moreover, IL6 and TNF values in this group were significantly decreased compared to FDW group (P < 0.05). Conclusion. Results in the present study show that FDW causes the pain response score to increase and cause proinflammatory cytokines in rat model but A. dracunculus L. leaf aqueous extract improves values of these parameters.

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“…Recently, Maham et al [13] performed various experimental models on mice and rats to assess antinociception triggered by the EO of Artemisia dracunculus L. (Asteraceae) [13]. They also identified the LD 50 dose of the EO as 1250 mg/kg.…”

Section: Animal Studiesmentioning

confidence: 99%

Essential Oils and Compounds against Pains in Animal Studies

Schabauer

Steflitsch

Buchbauer

2017

Natural Product Communications

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The positive impact of essential oils and compounds has been known for a long time. Essential oils are multicomponent mixtures and obtained by steam distillation of leaves or flowers or simply by pressing orange peels for example. Due to the broad-spectrum activity, essential oils can be used for a variety of disorders like sleeping problems, colds or gastrointestinal complaints. The focus of this paper is the use of essential oils against pain in animal studies. The broad use of analgesics like NSAIDs against headaches or menstrual cramps for example, is often associated with unpleasant side effects. Essential oils may help to reduce the analgesic doses.

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Antinociceptive effect of the essential oil of tarragon (Artemisia dracunculus)

Abstract: This study reported the peripheral and central antinociceptive activity of the EOAD and rationalized the traditional use of the plant in the treatment of different painful conditions.

Cited by 28 publications

References 32 publications

Effects of Artemisia dracunculus Aqueous Extract on Blood Sugar, Serum Insulin, Triglyceride and Liver Enzymes in Fructose Drinking Water Male Rats

Effects of Artemisia dracunculus Aqueous Extract on Blood Sugar, Serum Insulin, Triglyceride and Liver Enzymes in Fructose Drinking Water Male Rats

The Nociceptive and Anti-Inflammatory Effects ofArtemisia dracunculusL. Aqueous Extract on Fructose Fed Male Rats

Essential Oils and Compounds against Pains in Animal Studies

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