Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice

Linglu, Dun; Li, Yuxiang; Xu, Yawei; Zhou, Ru; Ma, Lin; Jin, Shaoju; Du, Junying; Sun, Tongwen; Yu, Jian‐Qiang

doi:10.1007/s10072-013-1603-6

Cited by 30 publications

(10 citation statements)

References 29 publications

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“…Studies have shown that MT (15-60 mg/kg, i.p.) had an anti-nociceptive effect on mechanical stimulation and cold stimulation of vincristine induced neuropathic pain in model mice (Dun L. L. et al, 2014). In addition, it has been shown that MT reduced vincristine-induced neuropathic pain in mice through mechanisms associated with down-regulation of expression of spinal cord Ras, phosphorylated c-Raf, p-ERK 1/2, TNF-a, and IL -6, and upregulation of the expression of IL-10 (Gong et al, 2016).…”

Section: Anti-nociceptive Activitymentioning

confidence: 97%

A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine

You

Yang

et al. 2020

Front. Pharmacol.

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Matrine (MT) is a naturally occurring alkaloid and an bioactive component of Chinese herbs, such as Sophora flavescens and Radix Sophorae tonkinensis. Emerging evidence suggests that MT possesses anti-cancer, anti-inflammatory, anti-oxidant, antiviral, antimicrobial, anti-fibrotic, anti-allergic, antinociceptive, hepatoprotective, cardioprotective, and neuroprotective properties. These pharmacological properties form the foundation for its application in the treatment of various diseases, such as multiple types of cancers, hepatitis, skin diseases, allergic asthma, diabetic cardiomyopathy, pain, Alzheimer's disease (AD), Parkinson's disease (PD), and central nervous system (CNS) inflammation. However, an increasing number of published studies indicate that MT has serious adverse effects, the most obvious being liver toxicity and neurotoxicity, which are major factors limiting its clinical use. Pharmacokinetic studies have shown that MT has low oral bioavailability and short half-life in vivo. This review summarizes the latest advances in research on the pharmacology, toxicology, and pharmacokinetics of MT, with a focus on its biological properties and mechanism of action. The review provides insight into the future of research on traditional Chinese medicine.

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Section: Anti-nociceptive Activitymentioning

confidence: 97%

A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine

You

Yang

et al. 2020

Front. Pharmacol.

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“…In a mouse model for squamous cell carcinoma, matrine was administered at a dosage of 250 g/kg with no apparent adverse impact on health (49). Furthermore, it has been reported that matrine could ease the pain of cancer patients receiving chemotherapy, enhance the body's immunity and protect major organs such as the heart, liver and kidney from being damaged by chemicals/drugs during chemotherapy (50)(51)(52), all of which could help improve the quality of life of lung cancer patients receiving chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway

Huang

Zhang

et al. 2014

Oncology Reports

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Abstract. Lung cancer is the leading cause of cancer-related mortality in humans. The prognosis for advanced lung cancer patients is extremely poor. Current standard care is rather ineffective for prolonging patient life while preserving satisfactory quality of life due to adverse side-effects. Matrine extracted from the traditional Chinese herbal plant Sophora flavescens was shown to induce cancer cell death in vitro. The aim of this study was to investigate the effect of matrine on the proliferation and apoptosis of lung cancer cells and the molecular basis of matrine-induced apoptosis. The results showed that matrine inhibited cell proliferation and induced apoptosis in lung cancer A549 and 95D cells in a dose-and time-dependent manner. The apoptotic effects of matrine on lung cancer cells appeared to act via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway and downregulation of the expression of the inhibitor of apoptosis protein (IAP) family proteins. Matrine exerts its cancer-killing effect via promoting apoptosis in lung cancer cells and may be a useful adjuvant therapeutic scheme for treating advanced lung cancer patients.

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“…In fact, the biological activities of matrine are more relevant to other applications of Ku-Shen other than anti-tumor activities. It is reported to possess a variety of pharmacological activities, including antipyretic ( Cho et al, 1986 ; Xiang and Jiang, 2013 ), antiepileptic ( Xiang and Jiang, 2013 ), antinociceptive ( Wang et al, 2013 ; Dun et al, 2014 ), anti-inflammatory ( Zhang B. et al, 2011 ; Wu G. et al, 2017 ), myocardial preservation ( Zhang et al, 2006 ), antifibrotic ( Zhang et al, 2001 ), anti-tumor ( Wu J. et al, 2017 ), anti-viral ( Li et al, 2005 ) and anti-angiogenic ( Li et al, 2010 ). Our predicted results demonstrated that matrine could target a molecular network related to multiple functions, which is consistent with the multi-target nature of traditional medicine.…”

Section: Discussionmentioning

confidence: 99%

Matrine Is Identified as a Novel Macropinocytosis Inducer by a Network Target Approach

Zhang

Wang

et al. 2018

Front. Pharmacol.

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Comprehensively understanding pharmacological functions of natural products is a key issue to be addressed for the discovery of new drugs. Unlike some single-target drugs, natural products always exert diverse therapeutic effects through acting on a “network” that consists of multiple targets, making it necessary to develop a systematic approach, e.g., network pharmacology, to reveal pharmacological functions of natural products and infer their mechanisms of action. In this work, to identify the “network target” of a natural product, we perform a functional analysis of matrine, a marketed drug in China extracted from a medical herb Ku-Shen (Radix Sophorae Flavescentis). Here, the network target of matrine was firstly predicted by drugCIPHER, a genome-wide target prediction method. Based on the network target of matrine, we performed a functional gene set enrichment analysis to computationally identify the potential pharmacological functions of matrine, most of which are supported by the literature evidence, including neurotoxicity and neuropharmacological activities of matrine. Furthermore, computational results demonstrated that matrine has the potential for the induction of macropinocytosis and the regulation of ATP metabolism. Our experimental data revealed that the large vesicles induced by matrine are consistent with the typical characteristics of macropinosome. Our verification results also suggested that matrine could decrease cellular ATP level. These findings demonstrated the availability and effectiveness of the network target strategy for identifying the comprehensive pharmacological functions of natural products.

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Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice

Cited by 30 publications

References 29 publications

A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine

A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine

Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway

Matrine Is Identified as a Novel Macropinocytosis Inducer by a Network Target Approach

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