Antinociceptive effect of Lecythis pisonis Camb. (Lecythidaceae) in models of acute pain in mice

Brandão, Marcela S.; Pereira, S.S.; Lima, David Fernandes; Oliveira, J.P.C.; Ferreira, Éverton L. F.; Chaves, Mariana Helena; Almeida, Fernanda Campos Sousa de

doi:10.1016/j.jep.2012.12.028

Cited by 20 publications

(18 citation statements)

References 26 publications

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“…[38][39][40] Another possible mechanism of the anti-inflammatory and antinociceptive effects may be the inhibition of cyclooxygenase activities, just as the aspirin. 41 Cyclooxygenase catalyzes the biosynthesis of prostaglandins from arachidonic acid. 42 Again the mechanism of antinociceptive effects may be through the inhibition of pain perception, impulse transmission and/or elevation of pain threshold in the hypothalamus.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, anti-inflammatory and antinociceptive activities of methanolic extract of Justicia secunda Vahl leaf

Onoja

Ezeja

Omeh

et al. 2017

Alexandria Journal of Medicine

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Background of study: Plants used for traditional medicine contain a wide range of substances which can be used to treat various infectious diseases. Aim: The study evaluated the in vitro antioxidant, antinociceptive, and anti-inflammatory activities of the methanolic extract of Justicia secunda Vahl leaf. Methods: The acute toxicity was performed with up and down method and the highest dose used was 2 g/kg. The anti-inflammatory activity was evaluated using the carrageenan and formalin-induced paw edema models, and antinociceptive activity was evaluated using acetic acid-induced writhing reflex and tail flick test models while the antioxidant activity was evaluated using 2,2-diphenyl-2picryl hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) photometric assay. Results: The extract was well tolerated as no signs of toxicity or death were noticed during the period of observation. The extract produced a concentration dependent increase in antioxidant activities in both DPPH and FRAP models. The extract produced its optimum activity at 400 lg/ml in both DPPH (54.07%) assay and FRAP (1.58 lM) assay. The extract produced significant (P < 0.05) dose-dependent increase in both anti-inflammatory and antinociceptive activities. The antinociceptive and anti-inflammatory activities of the extract (0.4 g/kg) were comparable with the reference drugs (aspirin and pentazocine) used in the study. Conclusion: This study suggests that J. secunda possesses anti-inflammatory, antinociceptive and antioxidant activities and also provide the pharmacological basis for its uses in traditional medicine for these purposes.

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Section: Discussionmentioning

confidence: 99%

Antioxidant, anti-inflammatory and antinociceptive activities of methanolic extract of Justicia secunda Vahl leaf

Onoja

Ezeja

Omeh

et al. 2017

Alexandria Journal of Medicine

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“…)31, a non-selective opioid receptor antagonist, prior to the administration of either morphine (10 mg/kg) or DHC (10 mg/kg). Then formalin (5%, 25 μl) was injected into the paw 15 min after the administration of morphine or DHC in the established formalin pain model.…”

Section: Methodsmentioning

confidence: 99%

Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines

Yin

Chu

et al. 2016

Sci Rep

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Dehydrocorydaline (DHC) is an alkaloidal component isolated from Rhizoma corydalis. Previous studies have shown that DHC has anti-inflammatory and anti-tumor effects and that it can protect the cardiovascular system. However, there are few studies of the antinociceptive effects of DHC in vivo. This study explored the antinociceptive effects and possible mechanisms of DHC in mice using two inflammatory pain models: the acetic acid-induced writhing test and the formalin paw test. The intraperitoneal administration of DHC (3.6, 6 or 10 mg/kg) showed a dose-dependent antinociceptive effect in the acetic acid-induced writhing test and significantly attenuated the formalin-induced pain responses in mice. The antinociceptive effects of DHC were not associated with changes in the locomotor activity or motor responses of animals, and no obvious acute or chronic toxic effects were observed in the mice. Furthermore, the use of naloxone confirmed the involvement of the opioid receptor in the central antinociceptive effects of DHC. DHC reduced formalin-induced paw edema, which indicated that DHC may produce an anti-inflammatory effect in the periphery. In the formalin test, DHC decreased the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that DHC has antinociceptive effects in mice.

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“…erefore, it was deduced that the levels of L-glutamate and NO increased. A previous study indicated that acetic acid-induced abdominal writhing was associated with NO production and the glutamatergic system [23]. Writhing may happen when ulcers cause abdominal pain, and glutamate was the major excitatory neurotransmitter involved in nociceptive signal transmission.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis of Fuzi Lizhong Decoction for the Treatment of Stomach Ulcers

Yang

Wang

2020

Evidence-Based Complementary and Alternative Medicine

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This study aims to understand the treatment of stomach ulcers with FLD and to identify its potential target genes as well as related pathways by transcriptomic analysis. Rat stomach mRNA from a blank group (BG), a model group (MG), an untreated-model group (u-MG), and a treated group (TG) was sequenced. A partial least-squares discriminant analysis (PLS-DA) was used to differentiate the MG from the BG, and the Deseq2 R Package was used to identify differentially expressed genes between these groups. Furthermore, t-tests based on transcripts per million (TPM) were used to select different genes between MG and BG and significantly retrieved genes in TG, except for self-retrieved genes in u-MG. Finally, pathways regulated by retrieved genes were analyzed with KEGG database. Results showed that 327 of the 32,623 total detected genes were different (p<0.05) between the MG and BG. Among these genes, eighteen genes were significantly retrieved after rats were treated with FLD in TG, and they were considered as target genes on which FLD acted. In conclusion, FLD was deduced to cure stomach ulcers by affecting glycerolipid metabolism, fatty acid degradation, circadian entrainment, circadian rhythm, and dopaminergic synapse.

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Antinociceptive effect of Lecythis pisonis Camb. (Lecythidaceae) in models of acute pain in mice

Abstract: These results indicate the antinociceptive effect of Lecythis pisonis leaves and suggest that this effect may be related to opioid pathway, K+ATP channels, and L-arginine-nitric oxide modulation. Furthermore, these data support the ethnomedical use of this plant.

Cited by 20 publications

References 26 publications

Antioxidant, anti-inflammatory and antinociceptive activities of methanolic extract of Justicia secunda Vahl leaf

Antioxidant, anti-inflammatory and antinociceptive activities of methanolic extract of Justicia secunda Vahl leaf

Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines

Transcriptomic Analysis of Fuzi Lizhong Decoction for the Treatment of Stomach Ulcers

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