Antinociceptive Effect of<i>Cyperi rhizoma</i>and<i>Corydalis tuber</i>Extracts on Neuropathic Pain in Rats

Choi, Jae-Gyun; Kang, Suk-Yun; Kim, Jae-Min; Roh, Dae Hyun; Yoon, Seo-Yeon; Park, Jin Bong; Lee, Jang Hern; Kim, Hyun Woo

doi:10.4196/kjpp.2012.16.6.387

Cited by 24 publications

(15 citation statements)

References 30 publications

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“…Also these studies report large variations with respect to number of administrations (either single, 3 days or 5 days administration) and dosage (ranging from 30 mg/kg to 20 g/kg). Furthermore none of these studies addressed the mechanism of YHS effect [ 7 – 10 ]. YHS is known to contain several alkaloids [ 11 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Antinociceptive Properties of the Corydalis yanhusuo Extract

et al. 2016

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Corydalis yanhusuo. W.T. extracts (YHS) are widely used for the treatment of pain and inflammation. There are a few studies that assessed the effects of YHS in pain assays; however, none of these studies has systematically compared its activities in the different pain animal modes namely: acute, inflammatory and chronic pain. Furthermore, little is known about the mechanism of YHS activity in these assays. The aim of this study was to systematically evaluate the antinociceptive properties of YHS by testing it in four standardized pain assays and to investigate its mechanism. YHS antinociceptive properties were analyzed in the tail flick, the formalin paw licking, the von Frey filament and the hot box assays after spinal nerve ligation, which monitors acute nociceptive, persistent inflammatory and chronic neuropathic pain, respectively. YHS pharmacological profile was determined by screening it against a battery of G-protein coupled receptors and its mechanism of action was studied using knock-out mice. Our study shows that YHS, at a non-sedative dose, increases the tail flick latency in the tail flick assay without resulting in development of tolerance. YHS also decreases paw licking time in the formalin assay. Further, YHS increases paw withdraw threshold and latency in the von Frey filament and the hot box assays, respectively. In vitro, YHS exhibits prominent dopamine receptor antagonistic properties. In dopamine D2 receptor knockout mice, its antinociceptive effects are attenuated in acute and neuropathic pain but not inflammatory pain assays. Our results therefore indicate that YHS effectively attenuates acute, inflammatory and neuropathic pain, without causing tolerance. The effects on acute and neuropathic pain, but not inflammatory pain, are at least partially mediated through dopamine D2 receptor antagonism. Since YHS is a dietary supplement commercially available in the United States, our data suggest that it might be a candidate for alternative pain treatment.

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Section: Introductionmentioning

confidence: 99%

The Antinociceptive Properties of the Corydalis yanhusuo Extract

et al. 2016

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“…Wang) is a perennial herb in the Papaveraceae family and has been used in traditional medicine on several disease5. Recently we have revealed that repetitive oral treatments of the extract from CT during the induction phase (day 0–5 after surgery) significantly alleviate chronic constriction injury (CCI)-induced MA, but not TH and reduce increase of spinal pNR1 in rats6. Levo-tetrahydropalmatine (l-THP) is one of active ingredient from Corydalis tuber and has an analgesic effects in several pain7891011.…”

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confidence: 99%

Antinociceptive Profile of Levo-tetrahydropalmatine in Acute and Chronic Pain Mice Models: Role of spinal sigma-1 receptor

Kang

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Choi

et al. 2016

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We have recently reported that repeated systemic treatments of extract from Corydalis yanhusuo alleviate neuropathic pain and levo-tetrahydropalmatine (l-THP) is one of active components from Corydalis. We designed this study to investigate antinociceptive effect of l-THP in acute and chronic pain models and related mechanism within the spinal cord. We found that intraperitoneal pretreatment with l-THP significantly inhibited the second phase of formalin-induced pain behavior. In addition, intrathecal as well as intraperitoneal pretreatment with l-THP reduced the mechanical allodynia (MA) induced by direct activation of sigma-1 receptor (Sig-1). In chronic constriction injury mice, these treatments remarkably suppressed the increase in MA and spinal phosphorylation of the NMDA receptor NR1 subunit expression on day 7 after surgery. Intrathecal treatment with l-THP combined with the Sig-1R antagonist, BD1047 synergistically blocked MA suggesting that l-THP modulates spinal Sig-1R activation. CatWalk gait analysis also supported that antinociceptive effect of l-THP as demonstrated by restoration of percentages of print area and single stance. Meanwhile, intrathecal pretreatment with naloxone, non-selective opioid receptor antagonist, did not affect the effect of l-THP. In conclusion, these results demonstrate that l-THP possesses antinociceptive effects through spinal Sig-1R mechanism and may be a useful analgesic in the management of neuropathic pain.

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“…Meanwhile, Radix linderae can effectively alleviate inflammation (Chen et al ., ). Rhizoma Corydalis may be useful to alleviate neuropathic pain (Choi et al ., ). Rhizoma Corydalis might act on opioid, γ‐aminobutyric acid (GABA) or dopamine receptors and thus alleviate painful conditions such as headache, chest pain, epigastric pain, abdominal pain and backache (Yuan et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Investigation of the effect of traditional Chinese medicine on pain and inflammation in chronic nonbacterial prostatitis in rats

2016

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According to traditional Chinese medicine, the symptoms of chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CNP/CPPS) may be treated using a cocktail of herbs that stimulate blood circulation ('activating blood circulation formula'). We investigated the effect of three doses of this formula on a rat model of CNP/CPPS. Male Wistar rats were injected with a saline extract of male sex accessory glands on days 0 and 30 to induce prostatitis and then treated daily by gavage between days 32 and 60. Treatment with low, medium and high doses of activating blood circulation formula resulted in an almost total rescue of paw withdrawal threshold at day 60, and treatment with the highest dose also significantly decreased prostate inflammation (assessed histopathologically). We further observed elevated serum prostaglandin E2 levels in the CNP/CPPS model which decreased upon high-dose treatment, and increased Cox-2 expression in the prostate and spinal cord dorsal horn which was rescued in both tissues in the high-dose group and in the prostate in the medium-dose group. These results shed light on a possible mechanism by which activating blood circulation therapy may alleviate pain in a rat model of CNP/CPPS by downregulating Cox-2 expression in the spinal cord, thereby raising the pain threshold. Further research will be needed to fully characterise the mechanism by which activating blood circulation therapy produces this therapeutic effect.

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Antinociceptive Effect ofCyperi rhizomaandCorydalis tuberExtracts on Neuropathic Pain in Rats

Cited by 24 publications

References 30 publications

The Antinociceptive Properties of the Corydalis yanhusuo Extract

The Antinociceptive Properties of the Corydalis yanhusuo Extract

Antinociceptive Profile of Levo-tetrahydropalmatine in Acute and Chronic Pain Mice Models: Role of spinal sigma-1 receptor

Investigation of the effect of traditional Chinese medicine on pain and inflammation in chronic nonbacterial prostatitis in rats

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